Comprehensive Review of Kojic Acid and Its Derivatives: Biological Activities, Safety, and Therapeutic Potential in Depigmentation

Year : 2025 | Volume : 16 | Issue : 02 | Page : 45 53
    By

    Sejal Rajendra Chaudhari,

  • Sunila A. Patil,

  • Amuruta N. Patil,

  • S. P. Pawar,

  1. Student, B. Pharm, Department of Pharmaceutics, P. S. G. V. P. Mandal’s College of Pharmacy, Shahada, Maharashtra, India
  2. Associate Professor, Department of Pharmaceutical Chemistry, P. S. G. V. P. Mandal’s College of Pharmacy, Shahada, Maharashtra, India
  3. Associate Professor, Department of Pharmaceutical Chemistry, P. S. G. V. P. Mandal’s College of Pharmacy, Shahada, Maharashtra, India
  4. Principal, Department of Pharmacy, P. S. G. V. P. Mandal’s College of Pharmacy, Shahada, Maharashtra, India

Abstract

There are several uses for kojic acid in human medicine, particularly in depigmentation. Additionally, derivatives of it are suggested to enhance efficacy, avoid side effects, and stop chemical degradation. With an eye toward human use and an attempt to clarify the action mechanisms, the goal of this study was to review the most recent scientific literature regarding the biological activities and safety information of kojic acid or its derivatives. During the evaluation of three distinct databases, the terms “toxicity,” “adverse effect,” “efficacy,” “effect,” “activity,” and “safety” were crossed with the word “kojic.” Articles were chosen based on predetermined standards. In addition to its depigmenting properties, kojic acid and its derivatives have antitumor properties and can function as antioxidants, antimicrobials, anti-inflammatories, radioprotectors, anticonvulsants, and agents for managing obesity. Following cell penetration, the molecules bind to the active site of tyrosinase, regulating factors involved in melanogenesis, modulating leucocytes, and scavenging free radicals, which results in depigmenting activity. As a result, ligands, size, and polarity all play significant roles in activity. Certain cancerous cell lines, such as those from melanoma, ovarian, breast, colon, and hepatocellular carcinomas, are susceptible to the cytotoxicity of kojic acid and its derivatives. In terms of safety, at the tested concentrations, kojic acid or its derivatives are safe compounds for human use. Applications in medicine, pharmacology, and cosmetics could benefit greatly from kojic acid and its derivatives.

Keywords: Kojic acid, activity, effect, action, safety, depigmentation

[This article belongs to Research and Reviews: A Journal of Pharmaceutical Science ]

How to cite this article:
Sejal Rajendra Chaudhari, Sunila A. Patil, Amuruta N. Patil, S. P. Pawar. Comprehensive Review of Kojic Acid and Its Derivatives: Biological Activities, Safety, and Therapeutic Potential in Depigmentation. Research and Reviews: A Journal of Pharmaceutical Science. 2025; 16(02):45-53.
How to cite this URL:
Sejal Rajendra Chaudhari, Sunila A. Patil, Amuruta N. Patil, S. P. Pawar. Comprehensive Review of Kojic Acid and Its Derivatives: Biological Activities, Safety, and Therapeutic Potential in Depigmentation. Research and Reviews: A Journal of Pharmaceutical Science. 2025; 16(02):45-53. Available from: https://journals.stmjournals.com/rrjops/article=2025/view=228504


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Regular Issue Subscription Review Article
Volume 16
Issue 02
Received 08/04/2025
Accepted 10/05/2025
Published 15/06/2025
Publication Time 68 Days
300

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