Synthesis, Characterization, Biological evaluation, and in silico study of aniline derivatives

Year : 2025 | Volume : 16 | Issue : 02 | Page : 25 32
    By

    Alka Tyagi,

  1. Associate Professor, Shri Pandit Baburao Chaughule College of Pharmacy, Thane, Maharashtra, India

Abstract

In many hospitals worldwide, bacterial infections brought on by resistant strains are wreaking havoc, particularly in patients who are already impaired by age, disease, and other conditions. Due to the bacterial resistance, it is required to search for newer antibacterial drugs or molecules. In the current study, we aimed to develop aniline derivatives, followed by their anti-bacterial and in silico studies. Out of all the synthesized derivatives, compound 4d was found to be most active, which is confirmed by both in silico as well as anti-bacterial studies of the synthesized compounds. The PDB ID of the protein is 2Y2T. The phenyl ring of alanine interacts with Leu 214A and Arg 211A in the binding pocket. The isatin ring interacts with Ala 3A of the protein. Both in vitro and in silico tests revealed that all the compounds had good to moderate antibacterial activity and resembled lead. As a result, there is a correlation between in-silico and in vivo research.

Keywords: Alanine derivatives, Anti-bacterial activity, In silico study, docking, Antibiotic resistance.

[This article belongs to Research and Reviews: A Journal of Pharmaceutical Science ]

How to cite this article:
Alka Tyagi. Synthesis, Characterization, Biological evaluation, and in silico study of aniline derivatives. Research and Reviews: A Journal of Pharmaceutical Science. 2025; 16(02):25-32.
How to cite this URL:
Alka Tyagi. Synthesis, Characterization, Biological evaluation, and in silico study of aniline derivatives. Research and Reviews: A Journal of Pharmaceutical Science. 2025; 16(02):25-32. Available from: https://journals.stmjournals.com/rrjops/article=2025/view=208897


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Regular Issue Subscription Original Research
Volume 16
Issue 02
Received 25/03/2025
Accepted 12/04/2025
Published 26/04/2025
Publication Time 32 Days
600

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