Investigation of bio-physical interaction between Nanoparticles, Colloids, and biomolecules: Pharmaco-medical application.


Year : 2024 | Volume : 13 | Issue : 03 | Page : 6-17
    By

    Gizachew Diga,

  1. Professor, Jimma University, Jimma, Ethiopia, Ethiopia

Abstract

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Currently, research into magnetic nanoparticles has become Popular. The fundamental principle involving the physics of magnetic nanoparticles is its interaction with biomolecules such as hemoglobin, DNA, and RNA. In this research, the nature Vander walls interactions, electrostatic repulsion, thermal interactions, and magnetic interaction between nanoparticles and molecule is explored. The interaction parameters such as Zeta potentials between layer, magnetic moment density, and Gibbs energy can are discussed by using DLVO theory and DNA Origami theory. These theorems can efficiently solve nanoparticles interaction with biomolecules. The aggregate and agglomeration of nanoparticles and colloids can also be determined by the DLVO theory. Unfortunately, the adhesion, steric, and magnetic interactions between nanoparticles could be determined by DLVO theory. This theory is therefore, suitable to determine the stability of colloidal dispersion. Moreover, DNA Origami theory is employed to describe a periodic folding of long strand of natural DNA single strand and fixing it with the short strand. Taking the spherical samples (sites) where the interaction takes place, the relation among the physical parameters including radius and area, Zeta potential, and distance between Helmholtz planes can be evaluated. For biomedical and pharmaceutical applications, the Colloidal stability of magnetic nanoparticles must be in aqueous suspensions states. It is revealed that the parameterized interaction between magnetic nanoparticles and biomolecules apparently useful for cell imaging, drug delivery, and cancer treatment.

Keywords: DNA Origami, DLVO theory, Magnetic nanoparticles, colloids, Biomolecules

[This article belongs to Research & Reviews : Journal of Physics ]

How to cite this article:
Gizachew Diga. Investigation of bio-physical interaction between Nanoparticles, Colloids, and biomolecules: Pharmaco-medical application.. Research & Reviews : Journal of Physics. 2025; 13(03):6-17.
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Gizachew Diga. Investigation of bio-physical interaction between Nanoparticles, Colloids, and biomolecules: Pharmaco-medical application.. Research & Reviews : Journal of Physics. 2025; 13(03):6-17. Available from: https://journals.stmjournals.com/rrjophy/article=2025/view=0


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Regular Issue Subscription Original Research
Volume 13
Issue 03
Received 04/01/2025
Accepted 13/01/2024
Published 14/01/2025
Publication Time 10 Days
110

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