Evaluation of Anti-cataract Potential of Carbocisteine by Using In Vitro Goat Lens Model

Year : 2026 | Volume : 16 | 02 | Page :
    By

    Pratik A. Bhand,

  • Hemant J. Pagar,

  1. Student, Department of Pharmacology, Samarth College of Pharmacy, Pune, Maharashtra, India
  2. Student, Department of Pharmacology, Dr. Vithalrao Vikhe Patil Foundation’s College of Pharmacy, Ahmednagar, Maharashtra, India

Abstract

This study includes Carbocisteine has four Oxygen molecules, one Sulfur molecule, and one Nitrogen molecule. Goat eyeballs were used in the present study. They were obtained from the slaughterhouse. Glucose at a concentration of 55 mM was used to induce cataracts; glucose (5.5 mM) concentration served as a normal control, and Ascorbic Acid served as a standard control. Incubation of lenses with glucose 55 mM showed opacification starting after 8 hrs at the periphery, on the posterior surface of the lens. This progressively increased towards the centre, with complete opacification at the end of 72 hrs. Positive control (Ascorbic acid 40µg/ml) – lenses exhibit small opacity; the transparent lens was not discovered. Test 1 (Carbocisteine 20µg/ml) – There is a small amount of opacity in the lenses; no clear lens was discovered. Test 2 (Carbocisteine 20µg/ml) – There is a small amount of opacity in the lenses; no clear lens was discovered. Test 3 (Carbocisteine 40µg/ml) – Zero-degree opacity occurs, and a clear lens is obtained. Test drug inhibits cataractogenesis. Test drug inhibits cataract genesis. This study showed that Carbocisteine-treated groups have been shown to increase the total protein content, retarding the process of cataractogenesis initiated by high glucose concentration. Carbocisteine possesses antioxidant activity; thus, it should have anticataract activity. Therefore, the carbocisteine drug shows antioxidant activity and the drug shows anticataract activity.

Keywords: Anti-cataract, Carbocisteine, Artificial aqueous humour, In-vitro, goat lens

How to cite this article:
Pratik A. Bhand, Hemant J. Pagar. Evaluation of Anti-cataract Potential of Carbocisteine by Using In Vitro Goat Lens Model. Research and Reviews: A Journal of Pharmacology. 2026; 16(02):-.
How to cite this URL:
Pratik A. Bhand, Hemant J. Pagar. Evaluation of Anti-cataract Potential of Carbocisteine by Using In Vitro Goat Lens Model. Research and Reviews: A Journal of Pharmacology. 2026; 16(02):-. Available from: https://journals.stmjournals.com/rrjop/article=2026/view=243590


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Ahead of Print Subscription Original Research
Volume 16
02
Received 19/04/2026
Accepted 08/05/2026
Published 10/05/2026
Publication Time 21 Days
21

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