Mohd. Wasiullah,
Piyush Yadav,
Arjun Yadav,
- Principal, Dept. Principal, Dept.of Pharmacy, Prasad Institute Technology, Jaunpur, Uttar Pradesh, India
- Professor & Head, Dept. of Pharmaceutical Chemistry, Dept.of Pharmacy, Prasad Institute ofTechnology, Jaunpur, Uttar Pradesh, India
- Student, Dept.of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
Abstract
Calotropis gigantea, a highly valued plant in traditional Indian pharmacology, has emerged as a promising candidate for therapeutic innovation. This review delves into the clinical safety and efficacy of C. gigantea in the 21st century, examining its historical use, phytochemical composition, and pharmacological properties. While traditional medicine has long utilized C. gigantea for various ailments, modern research has sought to validate these claims through scientific investigation. This review critically analyzes the available clinical evidence, highlighting the plant’s potential in managing conditions like inflammation, pain, and microbial infections. However, it also underscores the need for further rigorous clinical trials to establish definitive conclusions regarding their safety and efficacy. Additionally, the review discusses potential toxicity concerns associated with C. gigantea, emphasizing the importance of appropriate dosage and administration. In final analysis, C. gigantea demonstrates potential as a therapeutic agent, but ongoing research is vital to elucidate its therapeutic efficacy and safety profile, thereby facilitating its responsible and effective utilization in healthcare settings.
Keywords: Calotropis gigantea, traditional medicine, antimicrobial, antimalarial, antidiabetic, healing.
[This article belongs to Research & Reviews: A Journal of Pharmacology (rrjop)]
Mohd. Wasiullah, Piyush Yadav, Arjun Yadav. Review on Clinical Safety and Efficacy of Giant Calotropis in the 21st Century. Research & Reviews: A Journal of Pharmacology. 2025; 15(01):15-23.
Mohd. Wasiullah, Piyush Yadav, Arjun Yadav. Review on Clinical Safety and Efficacy of Giant Calotropis in the 21st Century. Research & Reviews: A Journal of Pharmacology. 2025; 15(01):15-23. Available from: https://journals.stmjournals.com/rrjop/article=2025/view=194584
References
- Rahman MS, Moly NN and Hossen: Antimicrobial, Cytotoxic and Antioxidant activity of the exudate of Calotropis gigantea. Int J Pharm Sci Res. 2013; 4(2); 745-753.
- Kumar G, Karthik L, Rao KV. A review on pharmacological and phytochemical profile of Calotropis gigantea Linn. Pharmacologyonline. 2011; 1:1-8.
- Amutha A., Jeyalalitha T and Kohila M 2018, Calotropis Gigantea A Review Paper. Int J Recent Sci Res. 9(10), pp. 29386- 29390.
- Sarkar S, Chakraverty R, Ghosh A. Calotropis Gigantea-a complete busket of Indian traditional medicine. Int. J. Pharm. Res. Sci. 2014; 2(1):7-17.
- Gharge VG, Ghadge DM, Shelar PA, Yadav AV. Importance of Pharmacognostic study of medicinal plants Calotropis gigantea (Linn.): A review. Int J Pharmacognosy. 2017; 4(11):363-71.
- Ansari SH, Ali M. New oleanene triterpenesfrom root bark of Calotropis procera Medicinal and Aromatic Plant Sci. 21(4):978-981 (1999).
- Oudhia P, Devendra S. Mahale, Meghana Phulapagar, Tejaswini Gosavi, Vaishali Bharti. Review on Calotropis gigantea use on Diabetic. Research Journal of Pharmacology and Pharmacodynamics 2023;15(1):36-1. doi: 10.52711/2321-5836.2023.00008
- Smith NM: Weeds of the wet/dry tropics of Australia a field guide. Environment Centre NT. 2002:112.
- kar KR and Basu BD. Indian medicinal plants. Vol. III, 1995, National book distributors, Dehradun 1607-1609.
- The Wealth of India: A Dictionary of Indian Raw Materials and Industrial Products (Industrial Products—Part I). Ind Med Gaz. 1949 Oct;84(10):476–7.
- Kumar S, Gupta A, Pandey AK. Calotropis procera Root Extract Has the Capability to Combat Free Radical Mediated Damage. ISRN Pharmacol. 2013 Oct 9;2013:691372. https://doi.org/10.1155/2013/691372
- Prabha MR, Vasanthak, (2011) Antioxidant, cytotoxicity and polyphenolic content of Calotropis procera (Ait.) R. Br. Flowers. J Appl Pharm Sci 1(07) :136-140
- Kumar V, Basu N (1994) Anti-inflammatory activity of the latex of Calotropis procera. J Ethnopharmacol 44:(2)123-125 https://doi.org/10.1016/0378-8741(94)90078-7
- Sharma P, Snarma J (1999) Evaluation of in vitro schizontocidal activity of plant parts of Calotropis procera-an ethnobotanical approach. J Ethnopharmacol 68:(1-3)83-95 https://doi.org/10.1016/S0378-8741(99)00052-5
- Yadav SK, Nagori BP, Desai PK (2014) Pharmacological characterization of different fractions of Calotropis procera (Asclepiadaceae) in streptozotocin induced experimental model of diabetic neuropathy. J. Ethnopharmacol 152:(2)349-357 https://doi.org/10.1016/j.jep.2014.01.020
- Anmad M, Gwarzo M, Anwar S (2016) Antioxidative and anti-hyperglycaemic effect of Calotropis procera in alloxan induced diabetic rats. J Med Plants Res 10 (5):54-58 https://doi.org/10.5897/JMPR2014.5704
- Williams R (2006) Global challenges in liver disease. Hepatology 44(3):521-526
- Shehab, N.G., Abu-Gharbieh, E. & Bayoumi, F.A. Impact of phenolic composition on hepatoprotective and antioxidant effects of four desert medicinal plants. BMC Complement Altern Med15, 401 (2015). https://doi.org/10.1186/s12906-015-0919-6
- Rasik A, Raghubir R, Gupta A, Shukla A, Dubey M, Srivastava S, Jain H, Kulshrestha D (1999) Healing potential of Calotropis procera on dermal wounds in Guinea pigs. J Ethnopharmacol 68(1-3):261-266 https://doi.org/10.1016/S0378-8741(99)00118-X
- Tsala DE, Nga N, Thiery BN, Bienvenue MT, Theophile D. Evaluation of the antioxidant activity and the healing action of the ethanol extract of Calotropis procera bark against surgical wounds. J Intercult Ethnopharmacol. 2015 Jan-Mar;4(1):64-9. doi: 10.5455/jice.20141211071136.
Research and Reviews: A Journal of Pharmacology
Volume | 15 |
Issue | 01 |
Received | 14/12/2024 |
Accepted | 06/01/2025 |
Published | 17/01/2025 |