Nutrient–Xenobiotic Crosstalk in Dairy Cattle: Implications for Metabolism, Immunity, Health, and Productivity in Resilient Dairy Development

Year : 2026 | Volume : 16 | Issue : 01 | Page : 37 46
    By

    Md. Emran Hossain,

  1. Professor, Department of Animal Science and Nutrition, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram, Bangladesh

Abstract

Dairy cattle are routinely exposed to a wide range of xenobiotics, including mycotoxins, heavy metals, pesticides, residues from veterinary drugs, and plant secondary metabolites, through feed, water, and environmental sources. These xenobiotics, being foreign to biological systems, can interfere with the absorption, metabolism, and utilization of essential nutrients, while also compromising immune function, organ health, and overall physiological performance. Chronic or subclinical exposure can reduce feed efficiency, disrupt energy and protein metabolism, and alter mineral and vitamin balance, leading to impaired growth, reproductive inefficiency, and reduced milk yield and quality. Nutrient–xenobiotic interactions are, therefore, critical in determining the severity of these effects. Nutrients can enhance detoxification pathways, support antioxidant defense, and stabilize metabolic and immune functions, whereas xenobiotics may inhibit enzymatic activities, compete for absorption, or induce oxidative stress. This review synthesizes current knowledge on the mechanisms underlying nutrient–xenobiotic interactions in dairy cattle and their consequences for metabolism, immunity, health, and productivity. It further highlights nutritional and management strategies, including dietary antioxidants, trace minerals, probiotics, feed binders, and optimized feeding practices, that can mitigate xenobiotic stress. Understanding these interactions is essential for maintaining animal resilience, optimizing productivity, and ensuring milk safety, thereby promoting sustainable and safe dairy production systems in an increasingly contaminated global agricultural landscape where livestock are subjected to multiple chemical stressors simultaneously.

Keywords: Dairy cattle, immunity, metabolism, productivity, xenobiotic

[This article belongs to Research and Reviews: A Journal of Neuroscience ]

How to cite this article:
Md. Emran Hossain. Nutrient–Xenobiotic Crosstalk in Dairy Cattle: Implications for Metabolism, Immunity, Health, and Productivity in Resilient Dairy Development. Research and Reviews: A Journal of Neuroscience. 2026; 16(01):37-46.
How to cite this URL:
Md. Emran Hossain. Nutrient–Xenobiotic Crosstalk in Dairy Cattle: Implications for Metabolism, Immunity, Health, and Productivity in Resilient Dairy Development. Research and Reviews: A Journal of Neuroscience. 2026; 16(01):37-46. Available from: https://journals.stmjournals.com/rrjons/article=2026/view=240787


References

  1. Lang T, Lipp AM, Wechselberger C. Xenobiotic toxicants and particulate matter: Effects, mechanisms, impacts on human health, and mitigation strategies. J Xenobiot. 2025;15(4):131. doi: 10.3390/jox15040131.
  2. Thakur M, Yadav V, Kumar Y, Pramanik A, Dubey KK. How to deal with xenobiotic compounds through environment friendly approach? Crit Rev Biotechnol. 2024;44(8):1574–93. doi: 10.1080/07388551.2024.2336527.
  3. Singh J, Singh BB, Tiwari HK, Josan HS, Jaswal N, Kaur M, Kostoulas P, Khatkar MS, Aulakh RS, Gill JPS, Dhand NK. Using dairy value chains to identify production constraints and biosecurity risks. Animals (Basel). 2020;10(12):2332. doi:10.3390/ani10122332.
  4. Uddin M, Uddin M, Mamun M, Hassan M, Khan M. Small scale dairy farming for livelihoods of rural farmers: Constraints and prospects in Bangladesh. J Anim Sci Adv. 2012;2:543–50.
  5. Paunlagui MM. Assessment of dairy system constraints and opportunities for the development of research, development and extension framework. Rome: FAO Agricultural Information System; 2009.
  6. Vicidomini C, Palumbo R, Moccia M, Roviello GN. Oxidative processes and xenobiotic metabolism in plants: Mechanisms of defense and potential therapeutic implications. J Xenobiot. 2024;14(4):84. doi: 10.3390/jox14040084.
  7. Rahman M, Hossain MM, Islam MS, Rahman MA, Hasan MR, Islam MA, Kabir SMR, Rahman MM. Harnessing the power of bacterial laccases for xenobiotic degradation in water: A 10-year overview. Sci Total Environ. 2024;918:170498. doi:10.1016/j.scitotenv.2024.170498.
  8. Iyevhobu KO, Aigbokhan EE, Osayande O, Ighodaro OM, Edeki SO, Omoregie ES. Xenobiotic distribution: A comprehensive review and toxicological implications. JORMA Int J Health Soc Sci. 2025;2(2):58–66. doi:10.64074/99wreq81.
  9. Khan MF, Hof C, Niemcová P, Murphy CD. Recent advances in fungal xenobiotic metabolism: Enzymes and applications. World J Microbiol Biotechnol. 2023. doi: 10.1007/s11274-023-03737-7.
  10. Miglani R, Chhabra D, Dixit A, Mishra S, Kumar V, Kumar A. Degradation of xenobiotic pollutants: An environmentally sustainable approach. Metabolites. 2022;12(9):818. doi:10.3390/metabo12090818.
  11. Wang L, Shao Z, Wang X, Lu W, Sun H. Xenobiotic-induced liver injury: Molecular mechanisms and disease progression. Ecotoxicol Environ Saf. 2025;303:118854. doi: 10.1016/j.ecoenv.2025.118854.
  12. Mandal S, Kumar S. Microbe-mediated xenobiotic degradation: Recent status and prospects. In: Plant-microbe interaction under xenobiotic exposure. Singapore: Springer; 2025. p.283–303. doi: 10.1007/978-981-96-8260-7_10.
  13. Parveen M, Paul S, Saha KK, Mandal NC. Exploring the role of earthworm gut bacteria in minimizing the noxious effects of xenobiotic compounds on plant growth. In: Plant-microbe interaction under xenobiotic exposure. Singapore: Springer; 2025. p.585–610. doi: 10.1007/978-981-96-8260-7_22.
  14. Wang Y, Li Y, Li Z, Peng J, Zhang S, Xie S. Xenobiotic metabolism and CNS cycling during biofilm formation in drinking water BAC systems. Chem Eng J. 2025:168765.
  15. Rojo de la Vega Guinea EM. Characterization of the molecular mechanisms of xenobiotic-induced NRF2 activation for disease prevention and intervention [dissertation]. 2018.
  16. Watkins JB, Smith GS, Hallford DM. Characterization of xenobiotic biotransformation in hepatic, renal and gut tissues of cattle and sheep. J Anim Sci. 1987;65(1):186–95. doi: 10.2527/jas1987.651186x.
  17. Aguilera P, Ortiz M, Aravena C, Ginocchio R. Dynamics and transformations of natural and xenobiotic compounds in soil environments. Rev Cienc Suelo Nutr Veg. 2008;8(Spec No). doi:10.4067/S0718-27912008000400024.
  18. Oo CY. Xenobiotic transfer into human milk [thesis]. Lexington (KY): University of Kentucky; 1995.
  19. Empey PE. Xenobiotic transporters in lactating mammary epithelial cells: Predictions for drug accumulation in breast milk [thesis]. 2007.
  20. Gradinaru AC, Solcan G, Munteanu A, Popescu O. Evaluation of some xenobiotic trace element residues (Pb, Cd, Cu, Zn) in bulk milk samples collected from Moldavian farms. 2009.
  21. Nishimura M, Yamaguchi M, Yamauchi A, Ueda N, Naito S. Role of soybean oil fat emulsion in the prevention of hepatic xenobiotic transporter mRNA regulation induced by overdose of fat-free total parenteral nutrition in infant rats. Drug Metab Pharmacokinet. 2005;20(1):46–54. doi: 10.2133/dmpk.20.46.
Regular Issue Subscription Review Article
Volume 16
Issue 01
Received 06/01/2026
Accepted 02/02/2026
Published 15/04/2026
Publication Time 99 Days
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