This is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.
Malik Hyder Ali,
Harsh Kumar,
- Assistant Professor, Department Computer Science and Engineering Akal University, Talwandi Sabo, India
- Researcher, Department of Computer Science and Engineering, Akal University Talwandi Sabo, India
Abstract
Alzheimer’s disease (AD) is a neurological condition that worsens with time and impairs a patient’s quality of life by causing cognitive loss. For prompt intervention and management of AD, early identification is essential. In this work, we propose a deep learning-based method for automatically classifying Alzheimer’s disease from medical imaging data using convolutional neural networks (CNNs). Our algorithm is intended to evaluate brain MRI images and detect anatomical variations suggestive of AD. The CNN architecture is designed to discriminate between people who are healthy, those who have mild cognitive impairment, and people who have Alzheimer’s disease with high accuracy and robustness. The model demonstrated noteworthy performance in terms of accuracy, sensitivity, and specificity when it was trained on a dataset of MRI scans. According to our findings, CNN-based models present a viable means of diagnosing Alzheimer’s disease early and precisely, which can help doctors decide on the best course of treatment. This work demonstrates the promise of deep learning for neuroimaging and its use in diagnosing neurodegenerative diseases.
Keywords: Alzheimer’s disease, Convolutional Neural Networks, deep learning, MRI, neuroimaging, early diagnosis, medical image analysis, mild cognitive impairment, automatic classification, neurodegenerative disorders
[This article belongs to Research and Reviews: A Journal of Neuroscience ]
Malik Hyder Ali, Harsh Kumar. Deep Learning-Based Alzheimer’s Disease Detection: A CNN Approach. Research and Reviews: A Journal of Neuroscience. 2025; 15(03):-.
Malik Hyder Ali, Harsh Kumar. Deep Learning-Based Alzheimer’s Disease Detection: A CNN Approach. Research and Reviews: A Journal of Neuroscience. 2025; 15(03):-. Available from: https://journals.stmjournals.com/rrjons/article=2025/view=232950
References
- Finder VH. Alzheimer’s Disease: A general introduction and pathomechanism. J Alzheimers Dis. 2010 Sep;22(Suppl 3):S5–19. doi:10.3233/JAD-2010-100975.
- Ji H, Liu Z, Yan WQ, Klette R. Early diagnosis of Alzheimer’s disease using deep learning. In: Proceedings of the 2nd International Conference on Control and Computer Vision (ICCCV). New York (NY): ACM; 2019 Jun. p. 87–91. doi:10.1145/3341016.3341024.
- Aruchamy S, Haridasan A, Verma A, Bhattacharjee P, Nandy SN, Vadali SRK. Alzheimer’s disease detection using machine learning techniques in 3D MR images. In: 2020 National Conference on Emerging Trends on Sustainable Technology and Engineering Applications (NCETSTEA). Piscataway (NJ): IEEE; 2020 Feb. p. 1–4. doi:10.1109/NCETSTEA48365.2020.9119923.
- Fong JX, Shapiai MI, Tiew YY, Batool U, Fauzi H. Bypassing MRI pre-processing in Alzheimer’s disease diagnosis using deep learning detection network. In: 2020 16th IEEE International Colloquium on Signal Processing & Its Applications (CSPA). Piscataway (NJ): IEEE; 2020 Feb. p. 219–24. doi:10.1109/CSPA48992.2020.9068680.
- Helaly HA, Badawy M, Haikal AY. Deep learning approach for early detection of Alzheimer’s disease. Cogn Comput. 2022 Sep;14(5):1711–27. doi:10.1007/s12559-021-09946-2.
- Al Shehri W. Alzheimer’s disease diagnosis and classification using deep learning techniques. PeerJ Comput Sci. 2022 Dec;8:e1177. doi:10.7717/peerj-cs.1177.
- Hussain E, Hasan M, Hassan SZ, Azmi TH, Rahman MA, Parvez MZ. Deep learning based binary classification for Alzheimer’s disease detection using brain MRI images. In: 2020 15th IEEE Conference on Industrial Electronics and Applications (ICIEA). Piscataway (NJ): IEEE; 2020 Nov. p. 1115–20. doi:10.1109/ICIEA48937.2020.9248213.
- Kaur U, Kumar H, Kaur R. AI in healthcare. In: Artificial Intelligence Applications in Healthcare. Hershey (PA): IGI Global; 2024. p. 140–69. doi:10.4018/979-8-3693-3609-0.ch006.
- A A, P M, Hamdi M, Bourouis S, Rastislav K, Mohmed F. Evaluation of neuro images for the diagnosis of Alzheimer’s disease using deep learning neural network. Front Public Health. 2022 Feb;10:834032. doi:10.3389/fpubh.2022.834032.
- Murugan S, et al. DEMNET: A deep learning model for early diagnosis of Alzheimer diseases and dementia from MR images. IEEE Access. 2021;9:90319–29. doi:10.1109/ACCESS.2021.3090474.
- Puente-Castro A, Fernandez-Blanco E, Pazos A, Munteanu CR. Automatic assessment of Alzheimer’s disease diagnosis based on deep learning techniques. Comput Biol Med. 2020 May;120:103764. doi:10.1016/j.compbiomed.2020.103764.

Research and Reviews: A Journal of Neuroscience
| Volume | 15 |
| Issue | 03 |
| Received | 27/05/2025 |
| Accepted | 14/07/2025 |
| Published | 25/11/2025 |
| Publication Time | 182 Days |
Login
PlumX Metrics