Comprehending and Managing Restless Leg Syndrome


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Year : 2025 | Volume : 15 | Issue : 01 | Page : –
    By

    Deepa Narayan Naik,

  1. Nursing Tutor, Department of Community health nursing, R.N.S College of Nursing, Department of Community health nursing, R.N.S College of Nursing, Murdeshwar, Karnataka, India

Abstract

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An need to move that arises during rest or is made worse by rest, that happens in the evening or at night, and that goes away or gets better with movement is the hallmark of restless legs syndrome (RLS), a frequent sensorimotor disease. The degree, frequency, and age of start of symptoms vary greatly; severe types can impair mood, quality of life, and sleep. Periodic leg movements are common in RLS patients while they sleep or are at rest. RLS is seen as a complicated disorder, with comorbidities, environmental variables, and predisposing genetic factors all contributing to the disorder’s manifestation.

RLS can occur on its own or in conjunction with comorbid conditions, such as renal disease and iron deficiency, as well as cardiovascular illness, diabetes mellitus, neurological, rheumatological, and respiratory conditions. Although the etiology is yet unknown, theories include altered adenosine and glutamatergic pathways, brain iron insufficiency, and failure in the dopaminergic and nociceptive systems. Because doctors don’t detect RLS well, it’s frequently misdiagnosed and treated. In severe forms, treatment recommendations advise starting medication with low dosages of α2δ ligands or dopamine agonists. Even while dopaminergic therapy is very successful at first, prolonged use of it might cause augmentation, a severe worsening of symptoms. Iron preparations and painkillers are further therapy.

Keywords: RLS (Restless Leg Syndrome), CNS (Central Nervous System), SSRI’s (selective serotonin reuptake inhibitors, TCA’s (tricyclic antidepressants), TSH (Thyroid-stimulating hormone) ICD (impulse control disorder), (BUN Blood urea nitrogen)

[This article belongs to Research and Reviews: A Journal of Neuroscience (rrjons)]

How to cite this article:
Deepa Narayan Naik. Comprehending and Managing Restless Leg Syndrome. Research and Reviews: A Journal of Neuroscience. 2025; 15(01):-.
How to cite this URL:
Deepa Narayan Naik. Comprehending and Managing Restless Leg Syndrome. Research and Reviews: A Journal of Neuroscience. 2025; 15(01):-. Available from: https://journals.stmjournals.com/rrjons/article=2025/view=0


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References

  1. Manconi M, Garcia-Borreguero D, Schormair B, Videnovic A, Berger K, Ferri R, et al. Restless legs syndrome. Nat Rev Dis Primers. 2021 Nov 3;7(1). Available from: https://www.nature.com/articles/s41572-021-00311-z
  2. Pratt DP. Restless Legs Syndrome/Willis-Ekbom Disease and Periodic Limb Movements: A Comprehensive Review of Epidemiology, Pathophysiology, Diagnosis and Treatment Considerations. Curr Rheumatol Rev. 2016;12(2):91-112.
  3. National Heart, Lung, and Blood Institute Working Group on Restless Legs Syndrome. Restless legs syndrome: detection and management in primary care. Am Fam Physician. 2000 Jul 01;62(1):108-14.
  4. Evidente VG, Adler CH. How to help patients with restless legs syndrome. Discerning the indescribable and relaxing the restless. Postgrad Med. 1999 Mar;105(3):59-61, 65-6, 73-4.
  5. Cesnik E, Casetta I, Turri M, Govoni V, Granieri E, Strambi LF, Manconi M. Transient RLS during pregnancy is a risk factor for the chronic idiopathic form. Neurology. 2010 Dec 07;75(23):2117-20.
  6. Takaki J, Nishi T, Nangaku M, Shimoyama H, Inada T, Matsuyama N, Kumano H, Kuboki T. Clinical and psychological aspects of restless legs syndrome in uremic patients on hemodialysis. Am J Kidney Dis. 2003 Apr;41(4):833-9.
  7. Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP, Trenkwalder C., International Restless Legs Syndrome Study Group. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med. 2003 Mar;4(2):121-32.
  8. Weinstock LB, Walters AS, Paueksakon P. Restless legs syndrome–theoretical roles of inflammatory and immune mechanisms. Sleep Med Rev. 2012 Aug;16(4):341-54.
  9. Winkelman JW. Considering the causes of RLS. Eur J Neurol. 2006 Oct;13 Suppl 3:8-14.
  10. Allen RP, Earley CJ. Restless legs syndrome: a review of clinical and pathophysiologic features. J Clin Neurophysiol. 2001 Mar;18(2):128-47.
  11. Gupta R, Dhyani M, Kendzerska T, Pandi-Perumal SR, BaHammam AS, Srivanitchapoom P, Pandey S, Hallett M. Restless legs syndrome and pregnancy: prevalence, possible pathophysiological mechanisms and treatment. Acta Neurol Scand. 2016 May;133(5):320-9.
  12. Askenasy N, Askenasy JJ. Restless Leg Syndrome in Neurologic and Medical Disorders. Sleep Med Clin. 2015 Sep;10(3):343-50, xv.
  13. Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, Zucconi M, Ferri R, Trenkwalder C, Lee HB., International Restless Legs Syndrome Study Group. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria–history, rationale, description, and significance. Sleep Med. 2014 Aug;15(8):860-73.
  14. Gamaldo CE, Earley CJ. Restless legs syndrome: a clinical update. Chest. 2006 Nov;130(5):1596-604.
  15. Dauvilliers Y, Benes H, Partinen M, Rauta V, Rifkin D, Dohin E, Goldammer N, Schollmayer E, Schröder H, Winkelman JW. Rotigotine in Hemodialysis-Associated Restless Legs Syndrome: A Randomized Controlled Trial. Am J Kidney Dis. 2016 Sep;68(3):434-43.
  16. Liu GJ, Wu L, Lin Wang S, Xu LL, Ying Chang L, Fu Wang Y. Efficacy of Pramipexole for the Treatment of Primary Restless Leg Syndrome: A Systematic Review and Meta-analysis of Randomized Clinical Trials. Clin Ther. 2016 Jan 01;38(1):162-179.e6.
  17. Zintzaras E, Kitsios GD, Papathanasiou AA, Konitsiotis S, Miligkos M, Rodopoulou P, Hadjigeorgiou GM. Randomized trials of dopamine agonists in restless legs syndrome: a systematic review, quality assessment, and meta-analysis. Clin Ther. 2010 Feb;32(2):221-37.
  18. Garcia-Borreguero D, Kohnen R, Silber MH, Winkelman JW, Earley CJ, Högl B, Manconi M, Montplaisir J, Inoue Y, Allen RP. The long-term treatment of restless legs syndrome/Willis-Ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the International Restless Legs Syndrome Study Group. Sleep Med. 2013 Jul;14(7):675-84.
  19. Grote L, Leissner L, Hedner J, Ulfberg J. A randomized, double-blind, placebo controlled, multi-center study of intravenous iron sucrose and placebo in the treatment of restless legs syndrome. Mov Disord. 2009 Jul 30;24(10):1445-52. Available from: [PubMed]Restless legs syndrome – Symptoms and causes. Mayo Clinic.; 2024. Available from: https://www.mayoclinic.org/diseases-conditions/restless-legs-syndrome/symptoms-causes/syc-20377168#:~:text=Many%20people%20with%20RLS%20find,RLS%20may%20interfere%20with%20napping ‌
Regular Issue Subscription Original Research
Volume 15
Issue 01
Received 14/12/2024
Accepted 16/01/2025
Published 13/02/2025
55