Snehal Nandkumar Patil Kutwade,
- Student, Department of Bioinformatics, BioNome, Bangalore, Karnataka, India
Abstract
Objective: Pongamia pinnata (L.), commonly known as Indian beech or pongam tree, is a tropical plant renowned for its medicinal properties in traditional medicine systems. Extracts derived from various parts of Pongamia pinnata have demonstrated antimicrobial, anti-inflammatory, and immunomodulatory activities. Such attributes make it a compelling candidate for exploring its therapeutic potential against HSV infections. Thymidine kinase is the target protein mostly used in the treatment of HSV1 infections. In this study the various phytocompounds present in the Pongamia pinnata are chosen to investigate their pharmacological characteristics and therapeutic aspects against the targeted protein thymidine kinase in the treatment of HSV1 infection. Method: In this study, the phytoconstituents of Pongamia pinnata were derived from IMPPAT database and structures were downloaded by using PubChem database. Pharmacological analysis of phytocompounds were done by using the SwissADME, ADMETLAB 2.0 tools. The protein structure is downloaded from RCSB-PDB and validated using PDBsum generate and BIOVIA Discovery Studio Software. By using the PyRx, virtual screening tool the docking was performed and results were investigated to calculate the binding affinity between targeted protein and phytocompounds (ligands). Result: The 3 phytocompounds of Pongamia pinnata, ovalichromene B, pongachromene and isopongachromene are discovered to show the high binding affinity with targeted protein thymidine kinase. Conclusion: The phytoconstituents of Pongamia pinnata have potential to be used in the treatment of herpes simplex virus 1 infection. However, further in vitro analysis is required to support this finding.
Keywords: Pongamia pinnata (L.), herpes simplex virus (HSV), thymidine kinase, phytocompounds, pharmacological analysis, toxicity analysis, molecular docking
[This article belongs to Research and Reviews: A Journal of Microbiology and Virology ]
Snehal Nandkumar Patil Kutwade. Exploring The Therapeutical Potential Of Pongamia Pinnata For Herpes Simplex Virus Type 1 (HSV-1). Research and Reviews: A Journal of Microbiology and Virology. 2024; 15(01):1-9.
Snehal Nandkumar Patil Kutwade. Exploring The Therapeutical Potential Of Pongamia Pinnata For Herpes Simplex Virus Type 1 (HSV-1). Research and Reviews: A Journal of Microbiology and Virology. 2024; 15(01):1-9. Available from: https://journals.stmjournals.com/rrjomv/article=2024/view=188802
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Research and Reviews: A Journal of Microbiology and Virology
| Volume | 15 |
| Issue | 01 |
| Received | 09/09/2024 |
| Accepted | 30/09/2024 |
| Published | 11/12/2024 |
| Publication Time | 93 Days |
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