Sarah Hasan Kadhum AL Huchaimi,
Maysoon Khudair AL Hadrawi,
Raja Jawad Mohmad,
- Lecturer, Department of Community Health, Kufa Technical Institute, Al-Furat Al-Awsat Technical University, Kufa, Al-Najaf, , Iraq
- Assistant Professor, Kufa Technical Institute, Al-Furat Al-Awsat Technical University, Kufa, Al-Najaf, , Iraq
- Lecturer, Kufa Technical Institute, Al-Furat Al-Awsat Technical University, Kufa, Al-Najaf, , Iraq
Abstract
Polycystic ovary syndrome (PCOS) is a common hormonal condition that affects women of reproductive age. It usually begins to appear during adolescence. The ovaries produce an abnormal amount of “androgens”, which are male sex hormones that are usually found in women in small quantities. Ovarian syndrome causes hormonal imbalances, irregular menstrual cycles, increased cysts in the ovaries, in addition to hair growth all over the body, acne, and pain in the pelvic area. Irregular menstrual cycles, often accompanied by a lack of ovulation, can make it difficult to get pregnant and cause infertility. The cause of polycystic ovary syndrome is unknown, but women with a family history or those with type 2 diabetes are more susceptible to it. The risk factors for polycystic ovary syndrome are obesity and lack of movement, in addition to genetic factors and family medical history. Where PCOS is associated with insulin resistance and Obesity also Diabetes Mellitus type 2, and Heart Disease, As well as recurrent miscarriage and various cancers, Cardiovascular Diseases (CVD), Chronic inflammation, and various cancers such as uterine and ovarian cancer. One of the most important pathological symptoms in women with polycystic ovary syndrome is the formation of several ovarian cysts containing immature eggs that grow at the same time, then their growth stops without reaching the appropriate size, and ovulation does not occur, and this is determined by ultrasound examination. The patient also suffers from infertility despite not taking contraindications for Pregnancy. Some of its symptoms are relieved by lifestyle changes, medications, and fertility treatments.so we designed this review to assess the relationship between polycystic ovary syndrome and some hormonal disturbances and Metabolic disturbances in an infected woman’s body.
Keywords: CVD, PCOS , Ovary, Metabolic
[This article belongs to Research and Reviews: A Journal of Microbiology and Virology ]
Sarah Hasan Kadhum AL Huchaimi, Maysoon Khudair AL Hadrawi, Raja Jawad Mohmad. A Review on The effect of Polycystic Ovary Syndrome on some Hormonal and Metabolic Disturbances in Women. Research and Reviews: A Journal of Microbiology and Virology. 2024; 15(01):21-28.
Sarah Hasan Kadhum AL Huchaimi, Maysoon Khudair AL Hadrawi, Raja Jawad Mohmad. A Review on The effect of Polycystic Ovary Syndrome on some Hormonal and Metabolic Disturbances in Women. Research and Reviews: A Journal of Microbiology and Virology. 2024; 15(01):21-28. Available from: https://journals.stmjournals.com/rrjomv/article=2024/view=188784
References
- Karkera S, Agard E, Sankova L. The clinical manifestations of polycystic ovary syndrome (PCOS) and the treatment options. Eur J Biol Med Sci Res. 2023;11(1):57–91.
- Jabeen F, Khadija S, Daud S. Prevalence of primary and secondary infertility. Saudi J Med. 2022;7(1):22–28.
- Joham AE, Norman RJ, Stener-Victorin E, Legro RS, Franks S, Moran LJ, et al. Polycystic ovary syndrome. Lancet Diabetes Endocrinol. 2022;10(9):668–680.
- Adnan AN, Hassan ASU. Evaluation of polycystic ovary syndrome (PCOS) through androstolone and pituitary hormones lab t J Sci Res Med Biol Sci. 2023;4(3):28–35.
- Dubey P, Reddy S, Sharma K, Johnson S, Hardy G, Dwivedi AK. Polycystic Ovary Syndrome, Insulin Resistance, and Cardiovascular Disease. Curr Cardiol Rep. 2024;1–13.
- Siddiqui S, Mateen S, Ahmad R, Moin S. A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS). J Assist Reprod Genet. 2022;39(11):2439–2473.
- Saharan A, Singh V, Singh R. Genetic Testing in Polycystic Ovary Syndrome. In: Genetic Testing in Reproductive Medicine. Singapore: Springer Nature Singapore; 2024. 81–103p.
- Kaur R, Kaur M, Suri V. Exploring long term health implications in four Rotterdam phenotypes of polycystic ovary syndrome. Anthropologie. 2024;62(1).
- Aggarwal S, Pandey K. Early identification of PCOS with commonly known diseases: Obesity, diabetes, high blood pressure and heart disease using machine learning techniques. Expert Syst Appl. 2023;217:119532.
- Mayrhofer D, Hager M, Walch K, Ghobrial S, Rogenhofer N, Marculescu R, et al. The prevalence and impact of polycystic ovary syndrome in recurrent miscarriage: a retrospective cohort study and meta-analysis. J Clin Med. 2020;9(9):2700.
- Li Z, Wang YH, Wang LL, Hu DT, Teng Y, Zhang TY, et al. Polycystic ovary syndrome and the risk of endometrial, ovarian and breast cancer: An updated meta-analysis. Scott Med J. 2022;67(3):109–220.
- Stamou MI, Smith KT, Kim H, Balasubramanian R, Gray KJ, Udler MS. Polycystic Ovary Syndrome Physiologic Pathways Implicated Through Clustering of Genetic Loci. J Clin Endocrinol Metab. 2024;109(4):968–977.
- Ali SS, Jabeen S. Clinical features and presentation of polycystic ovary syndrome. In: Polycystic Ovary Syndrome. Elsevier; 2024. 56–60p.
- Liu J, Wu Q, Hao Y, Jiao M, Wang X, Jiang S, et al. Measuring the global disease burden of polycystic ovary syndrome in 194 countries: Global Burden of Disease Study 2017. Hum Reprod. 2021;36(4):1108–1119.
- Pea J, Bryan J, Wan C, Oldfield AL, Ganga K, Carter FE, et al. Ultrasonographic criteria in the diagnosis of polycystic ovary syndrome: a systematic review and diagnostic meta-analysis. Hum Reprod Update. 2024;30(1):109–130.
- Chesnokov MS, Mamedova AR, Zhivotovsky B, Kopeina GS. A matter of new life and cell death: programmed cell death in the mammalian ovary. J Biomed Sci. 2024;31(1):31.
- Ojo OA, Nwafor-Ezeh PI, Rotimi DE, Iyobhebhe M, Ogunlakin AD, Ojo AB. Apoptosis, inflammation, and oxidative stress in infertility: A mini review. Toxicol Rep. 2023.
- Zhang KH, Zhang FF, Zhang ZL, Fang KF, Sun WX, Kong N, et al. Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation. Protein Cell. 2024;pwad065.
- Kumar GS, Garg K, Soni A, Dalal M. A Comprehensive review of preclinical models for polycystic ovary s Curr Drug Ther. 2024;19(4):426–437.
- Maduka AU, Okoye CA. Relationships Between Marital Stress, Depressive Symptoms, Psychache and Infertility Among Couples in Fertility Treatment, in Port Harcourt Nigeria. Soc Sci Res. 2024;10(1)
- Rangi SK, Llarena NC, Falcone T. Surgical Treatment of Endometriomas: Impact on Ovarian Reserve. In: Endometriosis-related Infertility: A Comprehensive Manual. Cham: Springer International Publishing; 2024. 131–48p.
- Malik PS, Sahoo RK, Sharawat S, Singh M, Garg V, Bhatia K, et al. Fertility and pregnancy in chronic myeloid leukemia: Real-world experience from an Indian tertiary care institution. Ann Hematol. 2023;102(8):2087–2096.
- Athar F, Karmani M, Templeman NM. Metabolic hormones are integral regulators of female reproductive health and function. Biosci Rep. 2024;44(1):BSR20231916.
- Lonardo MS, Cacciapuoti N, Guida B, Di Lorenzo M, Chiurazzi M, Damiano S, et al. Hypothalamic-ovarian axis and adiposity relationship in polycystic ovary syndrome: Physiopathology and therapeutic options for the management of metabolic and inflammatory aspects. Curr Obes Rep. 2024;1–20.
- Pratama G, Wiweko B, Asmarinah, Widyahening IS, Andraini T, Bayuaji H, et al. Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis. Sci Rep. 2024;14(1):8229.
- Naz S, Amerjee A. Management of subfertility in polycystic ovary syndrome. In: Polycystic Ovary Syndrome. Elsevier; 2024. 141–160.
- Aljaff NSA. Studying the effect of sex hormones and their relationship with thyroid hormones in some women suffering from secondary infertility and obesity in Baghdad Governorate. Eur Sci Methodol J. 2024;2(1):16–26.
- Ostrovsky V, Ulman M, Hemi R, Lurie S, Hazan I, Ari AB, et al. Selective peripheral tissue response to high testosterone levels in an infertile woman without virilization signs. Endocrinol Diabetes Metab Case Rep. 2024;2024(2).
- Sparić R, Andjić M, Rakić A, Bjekić-Macut J, Livadas S, Kontić-Vučinić O, et al. Insulin-sensitizing agents for infertility treatment in women with polycystic ovary syndrome: a narrative review of current clinical practice. Hormones. 2024;23(1):49–58.
- Stener-Victorin E, Teede H, Norman RJ, Legro R, Goodarzi MO, Dokras A, et al. Polycystic ovary syndrome. Nat Rev Dis Primers. 2024;10(1):27.
- Sultana R, Iqbal MJ, Islam R, Biswash PK. Association between polycystic ovary syndrome (PCOS) and pregnancy complications. Sch Int J Obstet Gynec. 2024;7(1):25–29.
- Rosato E, Sciarra F, Minnetti M, Degjoni A, Venneri MA. Clinical management of androgen excess and defect in women. Expert Rev Endocrinol Metab. 2024;19(1):21–35.
- Schleh M, Ryan B, Ahn C, Ludzki A, Van Pelt D, Pitchford L, et al. Insulin-mediated suppression of fatty acid release predicts whole-body insulin resistance of glucose uptake and skeletal muscle insulin receptor activation. bioRxiv. 2024;2024–02.
- Dewal RS, Yang FT, Baer LA, Vidal P, Hernandez-Saavedra D, Seculov NP, et al. Transplantation of committed pre-adipocytes from brown adipose tissue improves whole-body glucose homeostasis. iScience. 2024;27(2)
- Ramírez-Martínez L, Palafox-Gómez C, Porchia LM, López-Bayghen E. The potential for ketogenic diets to control glucotoxicity, hyperinsulinemia, and insulin resistance to improve fertility in women with polycystic ovary s Clin Exp Obstet Gynecol. 2024;51(3):57.
- Pandey M, Niroula K. Optimizing nutrition for PCOS management: A comprehensive guide. 2024.
- Tűű L, Nas K, Török M, Várbíró S. SHBG levels do not correlate with insulin levels in PCOS with appropriate fasting insulin sensitivity. J Clin Med. 2024;13(3):838.
- Misra S, Gada J, Dhole C, Varthakavi P, Bhagwat N. Comparative study of insulin sensitivity and resistance and their correlation with androgens in lean and obese women with polycystic ovary s Reprod Sci. 2024;31(3):754–76
- Büyükyilmaz G, Koca SB, Adigüzel KT, Boyraz M, Gurbuz F. The role of the AMH, SHBG, free androgen index and LH/FSH ratio in the diagnosis of polycystic ovary syndrome in a Turk Pediatr Dis J. 2024;18(1):34–40.
- Wongwananuruk T, Kongcharoensukying A, Pramyothin P, Indhavivadhana S, Tanmahasamut P, Rattanachaiyanont M, et al. Body fat distribution in thai reproductive-aged polycystic ovary syndrome women compared with non-polycystic ovary syndrome w Clin Exp Obstet Gynecol. 2024;51(2):52.
- Silva A, Motta A. Peroxisome proliferator-activated receptors and placental function in women with polycystic ovary syndrome. Reproduction. 2024;167(5).
- Ahima RS, Park HK. Adipokines and metabolism. In: Metabolic Syndrome: A Comprehensive Textbook. Cham: Springer International Publishing; 2024. 335–356p.
- Huang HYR, Badar S, Said M, Shah S, Bharadwaj HR, Ramamoorthy K, et al. The advent of RNA-based therapeutics for metabolic syndrome and associated conditions: a comprehensive review of the literature. Mol Biol Rep. 2024;51(1):1–22.
- Ali SM, Abdulhussein IF, Kazom SN. Comparison of letrozole vs clomiphene citrate for induction of ovulation in polycystic ovarian syndrome: An Iraqi study. Tex J Med Sci. 2024;30:23–39.
- Suhail HA. Early recurrent pregnancy loss. J Res Appl Sci Biotechnol. 2024;3(1):315–328.
- Khudir HA, Jawad SMA. Evaluation of relationship between GLP-1 and GIP hormones and insulin resistance in patients with type 2 diabetes in AL-Najaf Government. Al-Harf J. 2024;21.
- Kiran Z. Diagnostic criteria for polycystic ovary syndrome. In: Polycystic Ovary Syndrome. Elsevier; 2024. 61–74p.
- Wal A, Dash B, Jaiswal V, Gupta D, Mishra AK. Role of inflammation, oxidative stress, and angiogenesis in polycystic ovary syndrome (PCOS): Current perspectives. In: Targeting Angiogenesis, Inflammation, and Oxidative Stress in Chronic Diseases. 2024. 459–85p.
- Ansari RT, Syed U, Riaz M, Askari S, Anjum S. Unveiling the spectrum: A cross-sectional exploration of hirsutism causes in women. Pak J Med Sci. 2024;40(4).
- Davranova AD, Ruziyev S, Shomurodova D, Turakulova D. Polycystic ovary syndrome. Educ Res Universal Sci. 2024;3(4 Special):590–598.
- Farhana AA, Shi J. Systematic review on the various clinical features of polycystic ovary syndrome (PCOS) patients. J Life Sci. 2024;10(2):5159–5166.
- Gencoglu S. Relationship between elevated serum decorin levels and acne vulgaris in women with PCOS. Eur Rev Med Pharmacol Sci. 2024;28(2).
- Sengupta P, Dutta S, Hassan MF. Polycystic ovary syndrome (PCOS) and oxidative stress. J Integr Sci Technol. 2024;12(3):752.
- Liew FF, Dutta S, Sengupta P. Fertility treatment-induced oxidative stress and reproductive disorders. J Integr Sci Technol. 2024;12(3):756.
- Goldstein S, Samuni A. Chemistry of nitrogen dioxide and its biological implications. Redox Biochem Chem. 2024;100020.
- Yoshikawa T, You F. Oxidative stress and bio-regulation. Int J Mol Sci. 2024;25(6):3360.
- Hussain S, Rasul A, Hussain G, Rasheed M, Manan M, Riaz K, et al. Physiological significance of oxidative stress and anti-oxidative system. In: The Role of Natural Antioxidants in Brain Disorders. Cham: Springer International Publishing; 2023. 49–69p.
- Davalcanti RN, Pimentel TC, Esmerino EA, de Freitas MQ, Verruck S, Silva MC, et al. Cold plasma. In: Novel Technologies in Food Science. Cham: Springer International Publishing; 2023. 109–169p.
- Ahmad R, Surguchov A. Reactive oxygen species: Advances and developments. BoD–Books on Demand; 2024.
- Bhattacharya K, Dey R, Sen D, Paul N, Basak AK, Purkait MP, et al. Polycystic ovary syndrome and its management: In view of oxidative stress. Biomol Concepts. 2024;15(1):20220038.
- Cheng W, Tan L, Yu S, Song J, Li Z, Peng X, et al. Geniposide reduced oxidative stress-induced apoptosis in HK-2 cell through PI3K/AKT3/FOXO1 by m6A modification. Int Immunopharmacol. 2024;131:111820.

Research and Reviews: A Journal of Microbiology and Virology
| Volume | 15 |
| Issue | 01 |
| Received | 06/11/2024 |
| Accepted | 30/11/2024 |
| Published | 11/12/2024 |
| Publication Time | 35 Days |
Login
PlumX Metrics
