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Atul Khajuria,
Gagandeep Singh,
- Director & Professor, Department of Allied Health Sciences Desh Bhagat University, Mandi Gobindgarh, Panjab, India
- Faculty, Department of Allied Health Sciences Desh Bhagat University, Mandi Gobindgarh, Panjab, India
Abstract
Pregnancy-induced hypertension (PIH), including gestational hypertension and preeclampsia, is a leading cause of maternal and fetal complications. The regulation of blood pressure and overall pregnancy health is influenced by micronutrients and hormones. This study aimed to evaluate serum magnesium, serum iron, total iron binding capacity (TIBC), thyroid profile, and quadruple marker levels in hypertensive pregnant women and compare them to normotensive controls.
Methods:
A total of 1056 hypertensive pregnant women diagnosed with gestational hypertension or preeclampsia were enrolled in this cross-sectional study, along with a control group of 1056 normotensive pregnant women matched for age, gestational age, and socioeconomic status. Blood samples were collected to measure serum magnesium, serum iron, TIBC, thyroid profile (TSH, T3, T4), and quadruple markers (AFP, hCG, uE3, inhibin A) using immunoassays and automated analyzers. Data was analyzed using SPSS software, and comparisons between groups were made using t-tests and Mann-Whitney U tests.
Results:
Significant differences were found between hypertensive and normotensive groups for serum magnesium, serum iron, TIBC, thyroid hormones (TSH, T3, T4), and quadruple markers. Hypertensive pregnant women had significantly lower serum magnesium and iron levels, higher TIBC, and altered thyroid hormone profiles (higher TSH, lower T3 and T4 levels). Abnormalities in the quadruple markers were also observed, indicating potential risks for fetal growth restriction and preterm birth.
Conclusion:
This study highlights significant micronutrient deficiencies and hormonal imbalances in hypertensive pregnant women. Serum magnesium, iron, TIBC, thyroid profile, and quadruple marker abnormalities are prevalent and could serve as biomarkers for early detection and management of hypertensive disorders during pregnancy. Further research, particularly randomized controlled trials, is needed to explore the therapeutic potential of correcting these deficiencies and imbalances to improve maternal and fetal health.
Keywords: Pregnancy-induced hypertension, gestational hypertension, preeclampsia, serum magnesium, serum iron, total iron binding capacity (TIBC), thyroid profile, quadruple marker,
[This article belongs to Research and Reviews : A Journal of Medical Science and Technology ]
Atul Khajuria, Gagandeep Singh. Serum Magnesium, Iron, TIBC, and Hormonal Imbalances in Hypertensive Pregnant Women: A Comparative Study. Research and Reviews : A Journal of Medical Science and Technology. 2025; 14(02):-.
Atul Khajuria, Gagandeep Singh. Serum Magnesium, Iron, TIBC, and Hormonal Imbalances in Hypertensive Pregnant Women: A Comparative Study. Research and Reviews : A Journal of Medical Science and Technology. 2025; 14(02):-. Available from: https://journals.stmjournals.com/rrjomst/article=2025/view=208746
References
- Kothandaraman V. The role of serum magnesium in pregnancy-induced hypertension. J Adv Med Pharm Sci. 2021;3(1):1–5.
- Shaji Geetha S, Thomas J, Suganthi R, et al. Maternal serum iron status, hepcidin, and interleukin-6 levels in preeclampsia. Front Physiol. 2022;13:1049994. doi:10.3389/fphys.2022.1049994
- Maheshwari KU, Varsha S, Kumar NA. Study of serum iron and magnesium levels in pregnancy and its correlation with pregnancy-induced hypertension. Natl J Lab Med. 2020;9(4):1–5. doi:10.7860/NJLM/2020/45756/13879
- Taubert T, Gaillard R, Franco OH, et al. Maternal iron status in early pregnancy and blood pressure throughout pregnancy, placental hemodynamics, and the risk of gestational hypertensive disorders. Hypertension. 2023;81(5):1108–1117. doi:10.1161/HYPERTENSIONAHA.122.17972
- Liu Y, Burgess S, Larsson SC. Associations between genetically predicted iron status and cardioembolic ischemic stroke risk. J Am Heart Assoc. 2023;12(4):e034991. doi:10.1161/JAHA.122.034991
- Kothandaraman V. The role of serum magnesium in pregnancy-induced hypertension. J Adv Med Pharm Sci. 2021;3(1):1–5. (Duplicate of Reference 1—can be removed or replaced)
- Bandyopadhyay S, Saha D, Samanta S, et al. Hepcidin levels in preeclampsia: A meta-analysis. Front Physiol. 2022;13:1049994. doi:10.3389/fphys.2022.1049994
- Zhao W, Zhang H, Zhang M, et al. Magnesium supplementation and hypertension: A review. Hypertens Res. 2017;40(1):53–60. doi:10.1038/hr.2016.147
- Joffe M, Duggan C, Fawzi W, et al. Magnesium intake and risk of preeclampsia in pregnant women: A systematic review. J Hypertens. 2018;36(5):939–948. doi:10.1097/HJH.0000000000001732
- Zhou J, Zhang L, Tian Z, et al. Iron deficiency and its association with hypertensive disorders in pregnancy. Nutr Rev. 2019;77(4):239–248. doi:10.1093/nutrit/nuy078
| Volume | 14 |
| Issue | 02 |
| Received | 25/03/2025 |
| Accepted | 29/03/2025 |
| Published | 25/04/2025 |
| Publication Time | 31 Days |