Advances in Total Knee Replacement: A Systematic Review of Clinical Outcomes and Complications

Year : 2025 | Volume : 14 | Issue : 01 | Page : 41 56
    By

    Nitin Malik,

  • Abhishek Malik,

  • Chetan Raj Singh,

  • Arnav Chowdhary,

  1. Senior Resident, Department of Orthopaedics, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India
  2. Junior Resident, Department of Orthopaedics, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India
  3. Junior Resident, Department of Orthopaedics, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India
  4. Junior Resident, Department of Orthopaedics, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India

Abstract

Total Knee Replacement (TKR) is a widely used surgical intervention for patients with knee osteoarthritis and other degenerative knee disorders, offering significant improvements in pain relief, functional restoration, and quality of life. This systematic review synthesizes data from multiple clinical studies to evaluate the outcomes and complications associated with TKR. To find applicable research published in the last ten years, a thorough search of electronic databases was performed. Randomised controlled trials, cohort studies, and observational studies were all part of the research database that looked at clinical outcomes like pain alleviation, functional improvement, patient satisfaction, complication rates, and implant survival alongside other metrics. The review revealed that most patients undergoing TKR experience substantial pain relief and improved function, with satisfaction rates generally exceeding 80%. However, complications, such as infections, thromboembolism, and nerve injuries were reported in a small percentage of cases. Robotic-assisted surgery used in TKR showed potential for more precise alignment and better functional outcomes, but challenges, such as longer operative times, higher costs, and a learning curve remain. Additionally, factors, such as patient expectations, preoperative education, and postoperative rehabilitation significantly influenced patient satisfaction and overall outcomes. TKR continues to be an effective treatment for knee osteoarthritis, with advancements in surgical techniques and implants improving outcomes. However, complications persist, and a tailored approach considering individual patient factors is essential for optimizing results.

Keywords: Clinical outcomes, complications, implant survival, knee osteoarthritis, total knee replacement, patient satisfaction, robotic surgery

[This article belongs to Research and Reviews : A Journal of Medical Science and Technology ]

How to cite this article:
Nitin Malik, Abhishek Malik, Chetan Raj Singh, Arnav Chowdhary. Advances in Total Knee Replacement: A Systematic Review of Clinical Outcomes and Complications. Research and Reviews : A Journal of Medical Science and Technology. 2025; 14(01):41-56.
How to cite this URL:
Nitin Malik, Abhishek Malik, Chetan Raj Singh, Arnav Chowdhary. Advances in Total Knee Replacement: A Systematic Review of Clinical Outcomes and Complications. Research and Reviews : A Journal of Medical Science and Technology. 2025; 14(01):41-56. Available from: https://journals.stmjournals.com/rrjomst/article=2025/view=197069


References

  1. Allen KD, Thoma LM, Golightly YM. Epidemiology of osteoarthritis. Osteoarthr Cartil. 2022;30(2):184–95.
  2. Arden NK, Perry TA, Bannuru RR. Non-surgical management of knee osteoarthritis: Comparison of ESCEO and OARSI 2019 guidelines. Nat Rev Rheumatol. 2021;17(1):59–66.
  3. Bruyère O, Honvo G, Veronese N. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019;49(3):337–50.
  4. Quinn RH, Murray JN, Pezold R, Sevarino KS. Surgical Management of Osteoarthritis of the Knee. J Am Acad Orthop Surg. 2018;26(6):e191–3.
  5. Ackerman IN, Bohensky MA, Zomer E, Tacey M, Gorelik A, Brand CA. The projected burden of primary total knee and hip replacement for osteoarthritis in Australia to the year 2030. BMC Musculoskelet Disord. 2019;20(1):90.
  6. Trieu J, Gould DJ, Schilling C, Spelman T. Patient-reported outcomes following total knee replacement in patients <65 years of age–A systematic review and meta-analysis. J Clin Med. 2020;9(10):3150.
  7. Kuperman EF, Schweizer M, Joy P, Gu X, Fang MM. The effects of advanced age on primary total knee arthroplasty: A meta-analysis and systematic review. BMC Geriatr. 2016;16(1):41.
  8. Murphy BP, Dowsey MM, Choong PFM. The impact of advanced age on the outcomes of primary total hip and knee arthroplasty for osteoarthritis: A systematic review. JBJS Rev. 2018;6(6):e6.
  9. Bravi M, Longo UG, Laurito A, Greco A. Supervised versus unsupervised rehabilitation following total knee arthroplasty: A systematic review and meta-analysis. Knee. 2023;40:71–89.
  10. Konnyu KJ, Thoma LM, Cao W, Aaron RK. Rehabilitation for total knee arthroplasty: A systematic review. Am J Phys Med Rehabil. 2023;102(1):19–33.
  11. Ghoshal A, Bhanvadia S, Singh S. Factors associated with persistent postsurgical pain after total knee or hip joint replacement: A systematic review and meta-analysis. Pain Rep. 2023;8(1):e1052.
  12. Harmelink KEM, Zeegers A, Hullegie W, Bulstra SK, Bosma E, van der Weegen W. Are there prognostic factors for one-year outcome after total knee arthroplasty? A systematic review. J Arthroplasty. 2017;32(12): e13840–51.
  13. Lyman S, Lee YY, McLawhorn AS, Islam W, MacLean CH. What are the minimal and substantial improvements in the HOOS and KOOS and JR versions after total joint replacement? Clin Orthop Relat Res. 2018;476(12):2432–41.
  14. Jiang Y, Sanchez-Santos MT, Judge AD, Murray DW, Price AJ, Arden NK. Predictors of patient-reported pain and functional outcomes over 10 years after primary total knee arthroplasty: A prospective cohort study. J Arthroplasty. 2017;32(1):92–100.e2.
  15. Townsend LA, Roubion RC, Bourgeois DM. Impact of age on patient-reported outcome measures in total knee arthroplasty. J Knee Surg. 2018;31(6):580–4.
  16. Rogers NB, Grits D, Emara AK. Preoperative Veterans Rand-12 mental composite score of < 40 leads to increased healthcare utilization and diminished improvement after primary knee arthroplasty. J Arthroplasty. 2022;37(10):2178–85.
  17. Melnic CM, Paschalidis A, Katakam A, Sheth NP. Patient-reported mental health score influences physical function after primary total knee arthroplasty. J Arthroplasty. 2021;36(5):1277–83.
  18. Wang D, Wang HY, Luo ZY, Pei FX. Finding the optimal regimen for oral tranexamic acid administration in primary total hip arthroplasty: A randomized controlled trial. J Bone Joint Surg Am. 2019;101(5):438–45.
  19. Guo EW, Sayeed Z, Padela MT, Qazi M. Improving total joint replacement with continuous quality improvement methods and tools. Orthop Clin North Am. 2018;49(4):397–403.
  20. Guo B, Qin S, Huang Y. [Research progress of knee-salvage treatment for knee osteoarthritis]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018;32(10):1292–6.
  21. Lützner J, Lange T, Schmitt J, Kopkow C, Aringer M. The S2k guideline: Indications for knee endoprosthesis: Evidence and consent-based indications for total knee arthroplasty. Orthopade. 2018;47(9):777–81.
  22. Walker LC, Clement ND, Deehan DJ. Predicting the outcome of total knee arthroplasty using the WOMAC score: A review of the literature. J Knee Surg. 2019;32(8):736–41.
  23. Jones GG, Logishetty K, Clarke S, Collins R. Do patient-specific instruments (PSI) for UKA allow non-expert surgeons to achieve the same saw cut accuracy as expert surgeons? Arch Orthop Trauma Surg. 2018;138(11):1601–8.
  24. Makaram N, Clement ND, Hoo T, Nutton R, Burnett R. Survival of the low contact stress rotating platform total knee replacement is influenced by age: 1058 implants with a minimum follow-up of 10 years. Knee. 2018 Dec;25(6):1283–1291.
  25. Crawford DA, Berend KR, Lombardi AV. Management of the Failed Medial Unicompartmental Knee Arthroplasty. J Am Acad Orthop Surg. 2018 Oct 15;26(20): e426–e433.
  26. Soranoglou V, Poultsides LA, Triantafyllopoulos GK, Optimizing Intraoperative Blood Management for One-Stage Bilateral Total Knee Arthroplasty. HSS J. 2018 Jul;14(2):202–210.
  27. Abdel MP, Tibbo ME, Stuart MJ, Trousdale RT. A randomized controlled trial of fixed-versus mobile-bearing total knee arthroplasty: A follow-up at a mean of ten years. Bone Joint J. 2018 Jul;100-B (7):925–929.
  28. Loures FB, Correia W, Reis JH, Pires E Albuquerque RS, Outcomes after knee arthroplasty in extra-articular deformity. Int Orthop. 2019 Sep;43(9):2065–2070.
  29. Ryan SP, Goltz DE, Howell CB, Attarian DE. Skilled Nursing Facilities After Total Knee Arthroplasty: The Time for Selective Partnerships Is Now! J Arthroplasty. 2018 Dec;33(12):3612–3616.
  30. Canovas F, Dagneaux L. Quality of life after total knee arthroplasty, Orthopaedics & Traumatology: Surg & Res. ISSN 1877–0568. 2018;104(1Supplement):S41–S46. https://doi.org/10.1016/j.otsr.2017.04.017.
  31. Beckers, Gautier. Clinical Outcomes of Total Knee Arthroplasty in Patients Who Have Hemophilic Arthropathy: A Prospective Study. J Arthroplasty. 0(0).
  32. Woodland, Nicholas, Antony Takla. Patient-Reported Outcomes following Total Knee Replacement in Patients Aged 65 Years and Over–A Syst Rev J Clin Med. 2023;12(4):1613.
  33. Wainwright, TW Gill, M McDonald, DA. Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced Recovery After Surgery (ERAS (®)) Society recommendations. Acta Orthop. 2020;91:3–19.
  34. Masaracchio, M Hanney, WJ Liu, X. Timing of rehabilitation on length of stay and cost in patients with hip or knee joint arthroplasty: A systematic review with meta-analysis. PLoS ONE. 2017;12: e0178295.
  35. Nham, FH, Patel, I Zalikha, AK. Epidemiology of primary and revision total knee arthroplasty: Analysis of demographics, comorbidities and outcomes from the national inpatient sample. Arthroplasty. 2023;5:18.
  36. Li JW, Ma YS, Xiao LK. Postoperative pain management in total knee arthroplasty. Orthop Surg. 2019;11:755–61.
  37. Hootman JM, Helmick CG, Barbour KE. Updated projected prevalence of self-reported doctor-diagnosed arthritis and arthritis-attributable activity limitation among US adults, 2015–2040. Arthritis Rheumatol Hoboken NJ. 2016;68:1582–7.
  38. Elbuluk A, Deshmukh A, Inneh I. The present and future of genomics in adult reconstructive orthopaedic surgery. JBJS Rev. 2016;4:e61–66.
  39. Delanois RE, Mistry JB, Gwam CU. Current epidemiology of revision total knee arthroplasty in the United States. J Arthroplasty. 2017;32:2663–8.
  40. Wainwright TW, Gill M, McDonald DA. Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations. Acta Orthop. 2020;91:3–19.
  41. Ondeck NT, Bohl DD, Bovonratwet P. Discriminative ability of elixhauser’s comorbidity measure is superior to other comorbidity scores for inpatient adverse outcomes after total hip arthroplasty. J Arthroplasty. 2018;33:250–7.
  42. Karim HMR, Singha SK, Neema PK. Information technology-based joint preoperative assessment, risk stratification and its impact on patient management, perioperative outcome, and cost. Discov Craiova Rom. 2021;9:e130.
  43. Petrie MJ, Harrison TP, Salih S. Financial analysis of revision knee surgery at a tertiary referral centre as classified according to the Revision Knee Complexity Classification Knee. 2021;29:469–77.
  44. Fang CJ, Shaker JM, Ward DM. Financial burden of revision hip and knee arthroplasty at an orthopedic specialty hospital: Higher costs and unequal reimbursements. J Arthroplasty. 2021; 36:2680–4.
  45. Tokarski AT, Deirmengian CA, Lichstein PM. Medicare fails to compensate additional surgical time and effort associated with revision arthroplasty. J Arthroplasty. 2020;30:535–8.

Regular Issue Subscription Review Article
Volume 14
Issue 01
Received 26/12/2024
Accepted 20/01/2025
Published 05/02/2025
Publication Time 41 Days


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