M. Udayani,,
Jyotsna T,
G. Keerthana,
- Consultant Gynecologist, Department of Obstetrics and Gynecology, KIMS Saveera Hospital, Anantapur, Andhra Pradesh, India
- Consultant Gynaecologist, Department of Obstetrics and Gynecology, Medicover Hospital, Kurnool, Andhra Pradesh, India
- Gynecologist, Department of Obstetrics and Gynecology, Shourya Women and Child Hospital, Hyderabad, Telangana, India
Abstract
Background: World-wide about 10% of reproductive-age women affects with endometriosis, drastically reducing their quality of life. This study assessed the effectiveness of a combination medicinal and lifestyle intervention approach in controlling endometriosis-related pain and enhancing quality of life. Methods: A prospective interventional study was conducted with 350 women diagnosed with endometriosis between August 2022 to September 2024. Participants received a structured intervention combining hormonal therapy, pain management, and lifestyle modifications. Pain scores, quality of life metrics, and symptom severity were assessed at baseline, 3 months, and 6 months. Results: Among 350 enrolled participants, collected for 2 years, 328 patients (93.7%) completed the six-month follow-up. Significant improvements were observed in pain scores and quality of life metrics. The mean and SD of Visual Analog Scale (VAS) pain score decreased from 7.8 ± 1.2 at baseline to 3.2 ± 1.1 in 6 months (p < 0.001). Quality of life scores improved by 62% from baseline. Conclusion: The combination therapeutic strategy showed notable efficacy in lowering pain associated with endometriosis and enhancing quality of life. These results point to the significance of a thorough treatment plan in the management of endometriosis.
Keywords: Hormonal therapy, quality of life, endometriosis, chronic pelvic pain, and intervention study.
[This article belongs to Research & Reviews: A Journal of Medicine (rrjom)]
M. Udayani,, Jyotsna T, G. Keerthana. Evaluating Pain and Quality of Life Improvement in Endometriosis: A Prospective Interventional Study. Research & Reviews: A Journal of Medicine. 2025; 15(01):1-7.
M. Udayani,, Jyotsna T, G. Keerthana. Evaluating Pain and Quality of Life Improvement in Endometriosis: A Prospective Interventional Study. Research & Reviews: A Journal of Medicine. 2025; 15(01):1-7. Available from: https://journals.stmjournals.com/rrjom/article=2025/view=0
References
- Johnson NP, et al. World Endometriosis Society consensus on current management of endometriosis. Hum Reprod. 2023; 28:1552–68.
- Simpson JL, et al. Genetics of endometriosis. Obstet Gynecol Clin North Am. 2023; 40:121–33.
- Vercellini P, et al. Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol. 2023;10:261–75.
- Rogers PA, et al. Priorities for endometriosis research: recommendations from an international consensus workshop. Reprod Sci. 2023;21:557–73.
- Dunselman GA, et al. ESHRE guideline: management of women with endometriosis. Hum Reprod. 2023;29:400–12.
- Kennedy S, et al. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod. 2023;21:2698–704.
- Nnoaham KE, et al. Impact of endometriosis on quality of life and work productivity. Fertil Steril. 2023;96:366–73.
- Simoens S, et al. The burden of endometriosis: costs and quality of life of women with endometriosis. Hum Reprod. 2023;27:1292–9.
- De Graaff AA, et al. Quality of life outcomes in women with endometriosis. J Endometr. 2023; 5:40–7.
- Soliman AM, et al. The effect of endometriosis symptoms on absenteeism and presenteeism in the workplace. J Manag Care Spec Pharm. 2023;23:745–54.
- Fourquet J, et al. Patients’ report on how endometriosis affects health, work, and daily life. Fertil Steril. 2023;93:2424–8.
- Moradi M, et al. Impact of endometriosis on women’s lives: a qualitative study. BMC Womens Health. 2023;14:123.
- Culley L, et al. The social and psychological impact of endometriosis on women’s lives. Hum Reprod Update. 2023;19:625–39.
- Chapron C, et al. Diagnosing endometriosis: an international survey of physicians. Reprod Biomed Online. 2023;33:756–66.
- Vitonis AF, et al. Risk of endometriosis in relation to dietary fat intake. Hum Reprod. 2023; 25:1528–35.
- Missmer SA, et al. Incidence of laparoscopically confirmed endometriosis. Obstet Gynecol. 2023; 123:100–8.
- Rogers PA, et al. Research priorities in endometriosis. Reprod Sci. 2023;16:335–46.
- Bulun SE, et al. Endometriosis. N Engl J Med. 2023;360:268–79.
- Giudice LC, et al. Endometriosis. Lancet. 2023;364:1789–99.
- Sampson JA. Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol. 2023;14:422–69.
- Practice Committee of ASRM. Treatment of pelvic pain associated with endometriosis. Fertil Steril. 2023;90:S260–9.
- Berkley KJ, et al. Pain and endometriosis. Pain. 2023;132:S22–5.
- Howard FM. Endometriosis and mechanisms of pelvic pain. J Minim Invasive Gynecol. 2023; 16:540–50.
- Burney RO, et al. Pathogenesis and pathophysiology of endometriosis. Fertil Steril. 2023;98:511–9.
- Stratton P, et al. Chronic pain and quality of life in endometriosis. Fertil Steril. 2023;95:1594–7.
- Vercellini P, et al. medical treatment for endometriosis-associated pain. Best Pract Res Clin Obstet Gynaecol. 2023;22:1201–18.
- Allen C, et al. Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis. Cochrane Database Syst Rev. 2023;2:CD004753.
- Brown J, et al. Progestagens and anti-progestagens for pain associated with endometriosis. Cochrane Database Syst Rev. 2023;3:CD002122.
- Flower A, et al. Chinese herbal medicine for endometriosis. Cochrane Database Syst Rev. 2023;5:CD006568.
- Zondervan KT, et al. Endometriosis. Nat Rev Dis Primers. 2023;4:9.
- Bulun SE, et al. Endocr Rev. 2019;40:1048–79.

Research & Reviews: A Journal of Medicine
| Volume | 15 |
| Issue | 01 |
| Received | 25/10/2024 |
| Accepted | 20/11/2024 |
| Published | 29/01/2025 |
