The Relationship Between LOH Severity and Androgen Receptor Gene CAG Repeat Length of Korean Men Affected with LOH

Year : 2025 | Volume : 15 | Issue : 01 | Page : 32-37
    By

    Son -Ok Ri,

  • In-Hui Ryo,

  • Son-Hua Hwang,

  • Ri-Hyang Paek,

  • Kang Yu,

  1. Researcher, Department of Genetic and Immunologic Assay, Hospital of Pyongyang University of Medical Sciences, Pyongyang, North Korea.
  2. Researcher, Department of Ophthalmology, Pyongyang University of Medical Sciences, Pyongyang, North Korea
  3. Researcher, Department of Pediatrics, Pyongyang University of Medical Sciences, Pyongyang, North Korea
  4. Researcher, Department of Endocrinology and Metabolism, Pyongyang University of Medical Sciences, Ryonhwa-dong, Central District, Pyongyang, Democratic People’s Republic of Korea
  5. Researcher, Department of Endocrinology and Metabolism, Pyongyang University of Medical Sciences, Ryonhwa-dong, Central District, Pyongyang, Democratic People’s Republic of Korea

Abstract

Context: There have been no investigations on the severity of late-onset hypogonadism (LOH) of Korean male according to their androgen receptor gene CAG repeat length. Aim: To investigate the relationship between late-onset hypogonadism (LOH) and androgen receptor gene CAG repeat length in Korean men. A total of 106 patients with LOH from Pyongyang City participated in this study. LOH was diagnosed in individuals who had a serum testosterone level below 3.5 ng/mL, along with a positive score on the AMS questionnaire. Genomic DNA was extracted from the plasma of patients and then sequenced for analyzing CAG and CGC repeat, which were then compared with the AMS score of each participant. Results: The average length of CAG repeat of the participants was 21.8 ± 2.8 (15~26). Men with CAG repeat length of more than 21 manifested significantly more severe LOH symptoms than those with shorter length (p < 005). The sensitivity of this cutoff for a diagnosis of LOH was 94.6% and the specificity was 37.5%. Conclusions: Longer CAG repeat is associated with severe LOH symptoms and Korean men with CAG repeat length greater than 21 are more likely to be affected by LOH.

Keywords: Late-onset hypogonadism, androgen receptor, androgen receptor gene CAG repeat

[This article belongs to Research and Reviews: A Journal of Medicine ]

How to cite this article:
Son -Ok Ri, In-Hui Ryo, Son-Hua Hwang, Ri-Hyang Paek, Kang Yu. The Relationship Between LOH Severity and Androgen Receptor Gene CAG Repeat Length of Korean Men Affected with LOH. Research and Reviews: A Journal of Medicine. 2025; 15(01):32-37.
How to cite this URL:
Son -Ok Ri, In-Hui Ryo, Son-Hua Hwang, Ri-Hyang Paek, Kang Yu. The Relationship Between LOH Severity and Androgen Receptor Gene CAG Repeat Length of Korean Men Affected with LOH. Research and Reviews: A Journal of Medicine. 2025; 15(01):32-37. Available from: https://journals.stmjournals.com/rrjom/article=2025/view=195718



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Regular Issue Subscription Original Research
Volume 15
Issue 01
Received 03/10/2024
Accepted 03/12/2024
Published 29/01/2025
Publication Time 118 Days
Total Visits: 55


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