Psychological Profile of Patients Undergoing Hemodialysis and Its Association with Physiological Parameters

Year : 2026 | Volume : 16 | 02 | Page :
    By

    Hurmat Jan,

  1. Student, Department of Renal Science & Dialysis therapy Technology, Rayat Bahra University, Kharar, Punjab, India

Abstract

Background: End-stage renal disease (ESRD) is a chronic, progressive condition requiring maintenance hemodialysis, which imposes substantial physiological, psychological, and social burdens on patients. While physiological indicators are routinely monitored during treatment, the influence of psychological factors on these indicators and patients’ quality of life remains inadequately explored, particularly in the Indian context. Objective: To investigate the relationship between psychological variables (depression, anxiety, illness intrusiveness, and quality of life) and physiological indicators (serum albumin, serum creatinine, interdialytic weight gain, and physical activity) among patients with ESRD undergoing maintenance hemodialysis. Methods: A cross-sectional descriptive-correlational study was conducted among 127 patients undergoing maintenance hemodialysis at tertiary care hospitals. Participants were selected using purposive sampling. Psychological variables were assessed using standardized and validated questionnaires, while physiological data were obtained from patients’ medical records. Descriptive statistics, Pearson’s correlation, and linear regression analyses were performed to evaluate the associations between psychological and physiological variables, with statistical significance set at p < 0.05. Results: Significant associations were observed between several psychological and physiological parameters. Serum albumin demonstrated a significant negative correlation with anxiety (r = −0.222, p < 0.01). Serum creatinine was positively associated with illness intrusiveness (r = 0.253, p < 0.01) and depression (r = 0.204, p < 0.05). Interdialytic weight gain was positively correlated with illness intrusiveness (r = 0.247, p < 0.01) and anxiety (r = 0.203, p < 0.05). Physical activity was negatively associated with depression (r = −0.209, p < 0.05). Additionally, depression and anxiety exhibited a significant positive correlation (r = 0.348, p < 0.01), highlighting the close interaction between psychological distress and clinical outcomes in hemodialysis patients. Conclusion: The findings demonstrate a significant relationship between psychological distress and physiological health indicators in patients undergoing maintenance hemodialysis. Integrating routine psychological assessment and psychosocial interventions into standard nephrology care may improve treatment adherence, quality of life, and overall clinical outcomes. These results support the implementation of multidisciplinary care models that address both the psychological and physiological needs of individuals with ESRD.

Keywords: End-stage renal disease, Hemodialysis, Depression, Anxiety, Quality of life, Serum albumin, Serum creatinine, Interdialytic weight gain, Psychological health.

How to cite this article:
Hurmat Jan. Psychological Profile of Patients Undergoing Hemodialysis and Its Association with Physiological Parameters. Research and Reviews : A Journal of Life Sciences. 2026; 16(02):-.
How to cite this URL:
Hurmat Jan. Psychological Profile of Patients Undergoing Hemodialysis and Its Association with Physiological Parameters. Research and Reviews : A Journal of Life Sciences. 2026; 16(02):-. Available from: https://journals.stmjournals.com/rrjols/article=2026/view=249759


References

  1. Pastan S, Bailey J. Dialysis therapy. New England Journal of Medicine. 1998 May 14;338(20):1428-37.
  2. Anees M, Batool S, Imtiaz M, Ibrahim M. Socio-economic factors affecting quality of life of Hemodialysis patients and its effects on mortality. Pakistan journal of medical sciences. 2018 Jul;34(4):811.
  3. Arogundade FA, Zayed B, Daba M, Barsoum RS. Correlation between Karnofsky performance status scale and short-form health survey in patients on maintenance hemodialysis. Journal of the National Medical Association. 2004 Dec;96(12):1661.
  4. Bapat U, Kedlaya PG. Perceived illness intrusion among patients on hemodialysis. Saudi Journal of Kidney Diseases and Transplantation. 2009 May 1;20(3):386-91.
  5. Beck AT, Steer RA, Brown GK, Beck Depression Inventory—II M. Psychological Corporation: San Antonio. TX, USA. 1996:1-82.
  6. Abeles N. Proceedings of the American Psychological Association, Incorporated, for the year 1985: Minutes of the annual meeting of the Council of Representatives August 22 and 25, 1985, Los Angeles, California, and January 31-February 2, 1986, Washington, DC. American Psychologist. 1986 Jun;41(6):633.
  7. At B. Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation. Clin Psychol Rev. 1988;8:77-100.
  8. Endler NS, Rutherford A, Denisoff E. Beck Depression Inventory: Exploring its dimensionality in a nonclinical population. Journal of Clinical Psychology. 1999 Oct;55(10):1307-12.
  9. Zaragoza Fernández GM, Jiménez Mayor E, Chandu Nanwani A, Rodríguez Tudero C, De La Flor JC, Fernández Castillo R. Biochemical Associations with Depression, Anxiety, and Stress in Hemodialysis: The Role of Albumin, Calcium, and β2-Microglobulin According to Gender. Biomedicines. 2025 Dec 15;13(12):3092.
  10. Wang LJ, Wu MS, Hsu HJ, Wu IW, Sun CY, Chou CC, Lee CC, Tsai CR, Tsai YC, Chen CK. The relationship between psychological factors, inflammation, and nutrition in patients with chronic renal failure undergoing hemodialysis. The International Journal of Psychiatry in Medicine. 2012 Aug;44(2):105-18.
  11. Spyridaki A, Charonitaki A, Proestakis A, Orfanou E, Psylinakis E, Markaki AG. Anxiety sensitivity is associated with adverse body composition in hemodialysis patients. Psychology, Health & Medicine. 2026 May 14:1-7.
  12. Li YN, Shapiro B, Kim JC, Zhang M, Porszasz J, Bross R, Feroze U, Upreti R, Martin D, Kalantar-Zadeh K, Kopple JD. Association between quality of life and anxiety, depression, physical activity and physical performance in maintenance hemodialysis patients. Chronic diseases and translational medicine. 2016 Jun;2(02):110-9.
  13. Bossola M, Luciani G, Tazza L. Fatigue and its correlates in chronic hemodialysis patients. Blood purification. 2009 Aug 14;28(3):245-52.
Ahead of Print Subscription Original Research
Volume 16
02
Received 02/02/2026
Accepted 07/07/2026
Published 08/07/2026
Publication Time 156 Days
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