Comparison of Recovery Profile for Total Intravenous Anaesthesia (TIVA) Using Propofol And Remifentanil in Laparoscopic Surgeries

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Year : 2026 | Volume : 16 | Issue : 01 | Page : 39 50
    By

    Arushi Bhagat,

  • Kaisar Ahmad Bhat,

  • Mukesh Kumar,

  • Amir Latif,

  • Mohsin Zahoor,

  • Urbain Muzzaffar,

  1. Demonstrator, Department of Anaesthesia & OT Technology, BEE ENN College of Nursing and Healthsceince, Jammu, Jammu & Kashmir, India
  2. Assistant Professor, Department of Anaesthesia & OT Technology, BEE ENN College of Nursing and Healthsceince, Jammu, Jammu & Kashmir, India
  3. Assistant Professor, Department of Medical Lab Technology, BEE ENN College of Nursing and Healthscience, Jammu, Jammu & Kashmir, India
  4. Assistant Professor, Department of Allied health sciences, BEE ENN College of Nursing and Healthscience, Jammu, Jammu & Kashmir, India
  5. Assistant Professor, Department of Anaesthesia & OT Technology, BEE ENN College of Nursing and Healthsceince, Jammu, Jammu & Kashmir, India
  6. Assistant Professor, Department of Radiology Technology, BEE ENN College of Nursing and Healthscience, Jammu, Jammu & Kashmir, India

Abstract

Total Intravenous Anaesthesia (TIVA) has become an increasingly preferred technique in modern anaesthetic practice due to advantages such as reduced postoperative nausea and vomiting (PONV), improved hemodynamic stability, minimal environmental impact, and faster recovery compared to conventional inhalational anesthesia. Propofol in combination with remifentanil is widely used for TIVA because of its rapid onset and offset of action, which supports quick postoperative awakening and enhanced patient satisfaction. Target Controlled Infusion (TCI) or Manual Controlled Infusion (MCI) are the two methods available for delivering TIVA. TCI utilizes population-based pharmacokinetic models to automatically maintain a desired plasma or effect-site concentration, whereas MCI relies on manual adjustments, making it more operator-dependent and susceptible to variations in anaesthetic depth. By employing propofol and remifentanil in elective laparoscopic procedures, this prospective randomized comparative study seeks to assess and contrast the recovery characteristics of TCI and MCI. Seventy ASA grade I–II patients aged 18–65 years will be enrolled and randomly allocated into two equal groups. Group TCI will receive propofol infusion via a Benefusion Target Controlled Infusion pump, while Group MCI will receive propofol through a conventional manual syringe pump. Time to regain spontaneous breathing, time to respond to verbal commands, time to extubation, and time to obtain a Modified Aldrete Score ≥ 9 for leaving the operating room are among the recovery criteria that will be evaluated. Total propofol consumption will also be compared between groups. It is anticipated that TCI will provide faster emergence, more predictable recovery, and reduced anesthetic consumption compared to MCI due to better controlled anaesthetic delivery and stable depth of anesthesia. The study outcomes may support the wider adoption of TCI as an optimal technique for anesthesia management in laparoscopic procedures to maximize patient safety and recovery quality.

Keywords: TIVA, Target Controlled Infusion, Manual Controlled Infusion, Propofol, Remifentanil, Recovery Profile, Laparoscopic Surgery

[This article belongs to Research and Reviews : A Journal of Life Sciences ]

How to cite this article:
Arushi Bhagat, Kaisar Ahmad Bhat, Mukesh Kumar, Amir Latif, Mohsin Zahoor, Urbain Muzzaffar. Comparison of Recovery Profile for Total Intravenous Anaesthesia (TIVA) Using Propofol And Remifentanil in Laparoscopic Surgeries. Research and Reviews : A Journal of Life Sciences. 2026; 16(01):39-50.
How to cite this URL:
Arushi Bhagat, Kaisar Ahmad Bhat, Mukesh Kumar, Amir Latif, Mohsin Zahoor, Urbain Muzzaffar. Comparison of Recovery Profile for Total Intravenous Anaesthesia (TIVA) Using Propofol And Remifentanil in Laparoscopic Surgeries. Research and Reviews : A Journal of Life Sciences. 2026; 16(01):39-50. Available from: https://journals.stmjournals.com/rrjols/article=2026/view=240683


References

  1. Cuiabano IS, Naves RP, Diehl RB. Comparison of the recovery profile of sufentanil and remifentanil in total intravenous anesthesia: a systematic review and meta-analysis of randomized controlled trials. Brazilian Journal of Anesthesiology (English Edition). 2025 Jan 1;75(1):844558.
  2. Lee WK, Kim MS, Kang SW, Kim S, Lee JR. Type of anaesthesia and patient quality of recovery: a randomized trial comparing propofol–remifentanil total iv anaesthesia with desflurane anaesthesia. British journal of anaesthesia. 2015 Apr 1;114(4):663-8.
  3. Kateliya R, Dubey M, Chandra S, Sahay N. Comparison of recovery profiles in target-controlled infusions (TCI) versus manually controlled infusions for total intravenous anesthesia (TIVA) in laparoscopic surgeries. A randomized controlled trial. Journal of Anaesthesiology Clinical Pharmacology. 2023 Apr 1;39(2):258-63.
  4. Beleña JM, Núñez M, Vidal A, Anta D. Randomized double-blind comparison of remifentanil and alfentanil in patients undergoing laparoscopic cholecystectomy using total intravenous anesthesia. Journal of Anaesthesiology Clinical Pharmacology. 2016 Oct 1;32(4):487-91.
  5. Choi JY, Lee HS, Kim JY, Han DW, Yang JY, Kim MJ, Song Y. Comparison of remimazolam-based and propofol-based total intravenous anesthesia on postoperative quality of recovery: a randomized non-inferiority trial. Journal of clinical anesthesia. 2022 Nov 1;82:110955.
  6. Majholm B, Bartholdy J, Clausen HV, Virkus RA, Engbæk J, Møller AM. Comparison between local anaesthesia with remifentanil and total intravenous anaesthesia for operative hysteroscopic procedures in day surgery. British journal of anaesthesia. 2012 Feb 1;108(2):245-53.
  7. Daccache N, Wu Y, Jeffries SD, Zako J, Harutyunyan R, Pelletier ED, Laferrière-Langlois P, Hemmerling TM. Safety and recovery profile of patients after inhalational anaesthesia versus target-controlled or manual total intravenous anaesthesia: a systematic review and meta-analysis of randomised controlled trials. British Journal of Anaesthesia. 2025 Mar 11.
  8. Liang Z, Liu J, Chen S, Zhao X, Chen G, Xie Y, Wang D, Xing F, Mao Y, Zhang W, Wang Z. Postoperative quality of recovery comparison between ciprofol and propofol in total intravenous anesthesia for elderly patients undergoing laparoscopic major abdominal surgery: a randomized, controlled, double-blind, non-inferiority trial. Journal of clinical anesthesia. 2024 Dec 1;99:111660.
  9. Abdi A, Imani B, Zarei M, Abdolmaleki S, Zandi S, Vosough RN. The effect of isoflurane versus propofol-based total intravenous anesthesia on hemodynamic stability, intraoperative blood loss, surgical field quality, recovery characteristics, and complications in patients undergoing posterior lumbar fusion surgery: a randomized clinical trial. BMC anesthesiology. 2025 Jul 30;25(1):373.
  10. Kumar G, Garg R, Kumar A, Singh S. COMPARATIVE STUDY OF INHALATIONAL VS. INTRAVENOUS ANAESTHESIA ON RECOVERY PROFILES IN OUTPATIENT SURGERIES. International Journal of Medicine & Public Health. 2025 Apr 1;15(2).
Regular Issue Subscription Original Research
Volume 16
Issue 01
Received 30/10/2025
Accepted 02/02/2026
Published 03/02/2026
Publication Time 96 Days
1

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