D.V Surya Prakash,
Parnika Vashist,
Palak Priya,
Neha Singh,
Nitika Vats,
- Assistant Professor, Department of Biotechnology, Meerut Institute of Engineering and Technology, Uttar Pradesh, India
- Student, Department of Biotechnology, Meerut Institute of Engineering and Technology, Meerut, Uttar Pradesh, India
- Student, Department of Biotechnology, Meerut Institute of Engineering and Technology, Meerut, Uttar Pradesh, India
- Assistant Professor, Department of Biotechnology, Meerut Institute of Engineering and Technology, Uttar Pradesh, India
- Assistant Professor, Department of Biotechnology, Meerut Institute of Engineering and Technology, Uttar Pradesh, India
Abstract
Total artificial heart (TAH) devices are mechanical systems designed to take over the role of a failing heart in patients with severe heart failure. Unlike ventricular assistance devices (VADs), which only support one side of the heart, TAHs replace both ventricles, providing a possible solution for patients who cannot receive a heart transplant. Over time, TAH technology has evolved with a focus on improving biocompatibility, reducing complications related to the device, and improving patient outcomes. However, significant challenges remain, such as long-term durability, infection risks, and the need for ongoing anticoagulation. Despite these obstacles, TAHs have become a vital option for patients awaiting heart transplants or as a temporary solution to recovery. This paper examines the history, technological progress, clinical uses, and prospects of TAH devices, highlighting their potential to transform heart failure treatment in the future.
Keywords: Artificial, heart, treatment, ventricle, device
[This article belongs to Research and Reviews : A Journal of Life Sciences ]
D.V Surya Prakash, Parnika Vashist, Palak Priya, Neha Singh, Nitika Vats. From Concept to Clinical Practice: A Detailed Review of Total Artificial Heart Devices. Research and Reviews : A Journal of Life Sciences. 2025; 15(01):1-4.
D.V Surya Prakash, Parnika Vashist, Palak Priya, Neha Singh, Nitika Vats. From Concept to Clinical Practice: A Detailed Review of Total Artificial Heart Devices. Research and Reviews : A Journal of Life Sciences. 2025; 15(01):1-4. Available from: https://journals.stmjournals.com/rrjols/article=2025/view=193215
References
- Fumoto H, Horvath DJ, Rao S, et al. In vivo acute performance of the cleveland clinic self-regulating, continuous-flow total artificial heart. J Heart Lung Transplant. 2010;29(1):21–26.
- Dowling RD, Gray LA, Jr, Etoch SW, et al. Initial experience with the AbioCor implantable replacement heart system. J Thorac Cardiovasc Surg. 2004;127(1):131–141.
- Demondion P, Fournel L, Niculescu M, et al. The challenge of home discharge with a total artificial heart: the La Pitie Salpetriere experience. Eur J Cardiothorac Surg. 2013;44(5):843–848.
- Lund LH, Edwards LB, Kucheryavaya AY, et al. The registry of the International Society for Heart and Lung Transplantation: thirty-first official adult heart transplant report–2014; focus theme: retransplantation. J Heart Lung Transplant. 2014;33(10):996–1008.
- Thanavaro KL, Tang DG, Cooke RH, et al. Characteristics and survival of patients with the total artificial heart implanted for indications other than biventricular failure. J Heart Lung Transplant. 2013;32(4):S231.
- Copeland JG, Smith RG, Arabia FA, et al. Cardiac replacement with a total artificial heart as a bridge to transplantation. N Engl J Med. 2004;351(9):859–867.
- Kormos RL, Teuteberg JJ, Pagani FD, et al. Right ventricular failure in patients with the HeartMate II continuous-flow left ventricular assist device: incidence, risk factors, and effect on outcomes. J Thorac Cardiovasc Surg. 2010;139(5):1316–1324.
- Drakos SG, Janicki L, Horne BD, et al. Risk factors predictive of right ventricular failure after left ventricular assist device implantation. Am J Cardiol. 2010;105(7):1030–1035.
- Kirsch M, Mazzucotelli JP, Roussel JC, et al. Survival after biventricular mechanical circulatory support: does the type of device matter? J Heart Lung Transplant. 2012;31(5):501–508.
- Ryan TD, Jefferies JL, Zafar F, et al. The evolving role of the total artificial heart in the management of end-stage congenital heart disease and adolescents. ASAIO J. 2015;61(1):8–14.
- Szefner J. Control and treatment of hemostasis in cardiovascular surgery. The experience of La Pitié Hospital with patients on total artificial heart. Int J Artif Organs. 1995;18(10):633–648.
- DeVries WC. Surgical technique for implantation of the Jarvik-7-100 total artificial heart. JAMA. 1988;259(6):875–880.
- Copeland J, Copeland H, Nolan P, et al. Results with an anticoagulation protocol in 99 SynCardia total artificial heart recipients. ASAIO J. 2013;59(3):216–220.
- Mankad AK, Tang DG, Clark WB, et al. Persistent anemia after implantation of the total artificial heart. J Card Fail. 2012;18(6):433–438.
- Copeland JG, Smith RG, Arabia FA, et al. Total artificial heart bridge to transplantation: a 9-year experience with 62 patients. J Heart Lung Transplant. 2004;23(7):823–831.
- Copeland JG, Copeland H, Gustafson M, et al. Experience with more than 100 total artificial heart implants. J Thorac Cardiovasc Surg. 2012;143(3):727–734.
- Delgado R, 3rd, Wadia Y, Kar B, et al. Role of B-type natriuretic peptide and effect of nesiritide after total cardiac replacement with the AbioCor total artificial heart. J Heart Lung Transplant. 2005;24(8):1166–1170.
- Levinson MM, Copeland JG, Smith RG, et al. Indexes of hemolysis in human recipients of the Jarvik-7 total artificial heart: a cooperative report of fifteen patients. J Heart Transplant. 1986;5(3):236–248.

Research and Reviews : A Journal of Life Sciences
| Volume | 15 |
| Issue | 01 |
| Received | 13/01/2024 |
| Accepted | 26/12/2024 |
| Published | 09/01/2025 |
Login
PlumX Metrics