Integrative Therapeutics for Antimicrobial Resistance and Autoimmune Disease: Evidence and Pathways

Year : 2026 | Volume : 16 | Issue : 02 | Page : 25 30
By

Nishant Shukla,

  1. Professor and Ex. Head of Kayachikitsa, Department of Kayachikitsa, Shree Gulabkunverba Ayurved Mahavidyalaya (SGAM) (Affiliated to Gujarat Ayurved University (GAU)), Jamnagar, Gujarat, India

Abstract

Background: Antimicrobial resistance (AMR) is accelerating globally, while autoimmune diseases and adverse drug reactions (ADRs) continue to rise. Ayurveda offers immunomodulatory, antimicrobial, and detoxification‑oriented interventions that may complement biomedical strategies. Objective: To propose a hypothesis‑driven integrative model combining Ayurvedic phytotherapy, panchakarma detoxification, and personalized dosha‑based care with evidence‑based medical management to mitigate AMR emergence, modulate autoimmunity, and reduce ADR incidence. Methods: A synthesis of mechanistic literature on Ayurvedic herbs with antimicrobial or immune‑modulating properties, alongside reviews of alternative AMR therapeutics and integrative autoimmune care. Proposed trial designs include randomized add‑on studies stratified by immune phenotype, with outcomes such as microbial clearance, resistance gene dynamics, autoantibody titers, and ADR frequency. Results: Evidence suggests that non‑traditional therapeutics – including botanicals, peptides, probiotics, and immune‑modulating agents – can complement antimicrobial strategies and address limitations of conventional one‑drug–one‑target approaches. Ayurvedic herbs and formulations demonstrate antimicrobial and immunomodulatory effects in preclinical and clinical studies, while integrative autoimmune protocols show promising safety signals. Conclusion: A rigorously standardized integrative framework combining Ayurveda with modern diagnostics and stewardship warrants clinical trials to evaluate its potential to reduce antibiotic exposure, slow resistance selection, and modulate autoimmune pathways.

Keywords: Integrative medicine, Ayurveda, antimicrobial resistance, autoimmunity, adverse drug reactions, phytotherapy, drug resistance

[This article belongs to Research and Reviews : A Journal of Immunology ]

How to cite this article: Nishant Shukla. Integrative Therapeutics for Antimicrobial Resistance and Autoimmune Disease: Evidence and Pathways. Research and Reviews : A Journal of Immunology. 2026; 16(02):25-30.
How to cite this URL: Nishant Shukla. Integrative Therapeutics for Antimicrobial Resistance and Autoimmune Disease: Evidence and Pathways. Research and Reviews : A Journal of Immunology. 2026; 16(02):25-30. Available from: https://journals.stmjournals.com/rrjoi/article=2026/view=251756

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Regular Issue Subscription Review Article
Volume 16
Issue 02
Received 22/02/2026
Accepted 26/06/2026
Published 04/08/2026
Publication Time 163 Days

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