Experimental Study on the Effect of Membranous Milkvetch and Ledebouriella divaricate Immunomodulatory Tablets on cytokine production in allergic rhinitis model mice

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This is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.

Year : 2025 | Volume : 15 | Issue : 03 | Page :
    By

    Kum-Ryon Jang,

  • So-Hyang Rim,

  1. Researcher, Department of medical Science, Pyongyang University of Medical Sciences, Pyongyang, Democratic People’s Republic of Korea, Korea
  2. Researcher, Department of medical Science, Pyongyang University of Medical Sciences, Pyongyang, Democratic People’s Republic of Korea, Korea

Abstract

We have established allergic rhinitis models for use in the treatment of allergic rhinitis with the help of the traditionall Koryo medicine administration, lade-screen Powder-extracted Membranous Milkvetch and Ledebouriella divaricate immunomodulatory tablet and the effect of lade-screen Powder on cytokine production in allergic rhinitis model mice. In the allergic rhinitis model, the administration of Membranous Milkvetch and Ledebouriella divaricate immunomodulatory tablets, along with Lade-screen Powder, demonstrated significant therapeutic effects. These interventions markedly reduced the behavioral score, indicating an improvement in allergic symptoms and overall disease severity. Additionally, treatment with these formulations led to a notable decrease in the splenic lymphocyte stimulation index, suggesting suppression of abnormal immune activation. Serum analysis and splenic cell culture supernatant further revealed an immunoregulatory shift, characterized by a significant increase in IFN-γ and IL-2 levels, cytokines associated with Th1 immune responses, while simultaneously showing a marked reduction in IL-4 levels, a key mediator of Th2-driven allergic reactions. This indicates a potential balancing of Th1/Th2 responses and highlights the immunomodulatory potential of these herbal preparations in managing allergic rhinitis.

Keywords: Membranous Milkvetch and Ledebouriella divaricate immunomodulatory tablets, lade -screen Powder, Allergic rhinitis(AR), Cytokine regulation, Anti-allergic therapy.

[This article belongs to Research and Reviews : A Journal of Immunology ]

How to cite this article:
Kum-Ryon Jang, So-Hyang Rim. Experimental Study on the Effect of Membranous Milkvetch and Ledebouriella divaricate Immunomodulatory Tablets on cytokine production in allergic rhinitis model mice. Research and Reviews : A Journal of Immunology. 2025; 15(03):-.
How to cite this URL:
Kum-Ryon Jang, So-Hyang Rim. Experimental Study on the Effect of Membranous Milkvetch and Ledebouriella divaricate Immunomodulatory Tablets on cytokine production in allergic rhinitis model mice. Research and Reviews : A Journal of Immunology. 2025; 15(03):-. Available from: https://journals.stmjournals.com/rrjoi/article=2025/view=231720


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Regular Issue Subscription Original Research
Volume 15
Issue 03
Received 08/05/2025
Accepted 03/09/2025
Published 13/11/2025
Publication Time 189 Days
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