Climate Change and Respiratory Allergy

Year : 2025 | Volume :15 | Issue : 01 | Page : 18-30
    By

    P.C Kathuria,

  • Manisha Rai,

  1. Senior Consultant, Department of Chest and Allergy, BLK Super Speciality Hospital, New Delhi, India
  2. Associate Consultant, Department of Allergy, National Allergy Centre, New Delhi, India

Abstract

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Climate change, a global issue, directly and indirectly impacts human health while posing a significant threat to animals and ecosystems. As part of the exposome, it influences various factors like seasonality, production, and the distribution of airborne allergens due to rising carbon dioxide levels and temperatures. These environmental changes also contribute to increased epithelial permeability, microbial imbalances, and heightened allergic reactions to pollen and fungal spores. Earth’s average surface temperature, currently around 14°C, has risen by 1°C over the past century, reflecting the growing urgency of this crisis. This has resulted in change in the environmental pattern and can have serious impact on vulnerable population, such as atopic individuals, elderly, children, or pregnant women. Climate change, air pollution, & reduced biodiversity are inter-related and has led to an increase in respiratory allergy diseases. This review emphasizes the important steps to mitigate the health disparities arising from global warming, climate change, and aeroallergen respiratory allergic diseases.

Keywords: Climate change, Green-house gases (GHGs), particulate matter (PM), volatile organic compounds (VOCs), sand & dust storm (SDS), ozone, carbon dioxide (CO2)

[This article belongs to Research and Reviews : A Journal of Immunology (rrjoi)]

How to cite this article:
P.C Kathuria, Manisha Rai. Climate Change and Respiratory Allergy. Research and Reviews : A Journal of Immunology. 2025; 15(01):18-30.
How to cite this URL:
P.C Kathuria, Manisha Rai. Climate Change and Respiratory Allergy. Research and Reviews : A Journal of Immunology. 2025; 15(01):18-30. Available from: https://journals.stmjournals.com/rrjoi/article=2025/view=0

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References

  1. Sanderson K. COP28 climate summit signals the end of fossil fuels – but is it enough? Nature. 2023 Dec;624(7992):484–485.
  2. Sampath V, Aguilera J, Prunicki M, Nadeau KC. Mechanisms of climate change and related air pollution on the immune system leading to allergic disease and asthma. Semin Immunol. 2023 May;67:101765.
  3. Domingo KN, Gabaldon KL, Hussari MN, et al. Impact of climate change on paediatric respiratory health: pollutants and aeroallergens. Eur Respir Rev. 2024;33:230249.
  4. Soyer OU, Akdis M, Ring J, Behrendt H, Crameri R, Lauener R, et al. Mechanisms of peripheral tolerance to allergens. Allergy. 2013;68(2):161–70.
  5. Sampath V, Nadeau KC. Newly identified T cell subsets in mechanistic studies of food immunotherapy. J Clin Invest. 2019;129(4):1431–1440.
  6. Kantor R, Silverberg JI. Environmental risk factors and their role in the management of atopic dermatitis. Expert Rev Clin Immunol. 2017;13(1):15–26.
  7. Hendricks A, Eichenfield L, Shi V. The impact of airborne pollution on atopic dermatitis: a literature review. Brit J Dermatol. 2020;183(1):16–23.
  8. Parker ER, Mo J, Goodman RS. The Dermatological Manifestations of Extreme Weather Events: A Comprehensive Review of Skin Disease and Vulnerability. J Climate Change Health. 2022:100162.
  9. Liu T, Zhang L, Joo D, Sun S-C. NF-κB signaling in inflammation, Signal Transduction and Targeted Therapy. 2017;2(1):17023.
  10. Brunst KJ, Leung Y-K, Ryan PH, Hershey GKK, Levin L, Ji H, et al. Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma. J Allergy Clin Immunol. 2013;131(2):592–594. e3.
  11. Nadeau K, McDonald-Hyman C, Noth EM, Pratt B, Hammond SK, Balmes J, et al. Ambient air pollution impairs regulatory T-cell function in asthma. J Allergy Clin Immunol. 2010;126(4):845–852. e10.
  12. Main LC, Wolkow AP, Tait JL, Della Gatta P, Raines J, Snow R, et al. Firefighter’s Acute Inflammatory Response to Wildfire Suppression. J Occup Environ Med. 2020;62(2):145–148.
  13. Ferguson MD, Semmens EO, Dumke C, Quindry JC, Ward TJ. Measured Pulmonary and Systemic Markers of Inflammation and Oxidative Stress Following Wildland Firefighter Simulations. J Occup Environ Med. 2016;58(4):407–13.
  14. Poulain-Godefroy O, Bouté M, Carrard J, Alvarez-Simon D, Tsicopoulos A, de Nadai P. The Aryl Hydrocarbon Receptor in Asthma: Friend or Foe? Int J Mol Sci. 2020;21(22).
  15. Reinmuth-Selzle K, Kampf CJ, Lucas K, Lang-Yona N, Fröhlich-Nowoisky J, Shiraiwa M, et al. Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants. Environ Sci Technol. 2017;51(8):4119–4141.
  16. Zhao F, Elkelish A, Durner J, Lindermayr C, Winkler JB, Ruёff F, et al. Common ragweed (Ambrosia artemisiifolia L.): allergenicity and molecular characterization of pollen after plant exposure to elevated NO2. Plant Cell Environ. 2016;39(1):147–64.
  17. Ambika Manirajan B, Hinrichs AK, Ratering S, Rusch V, Schwiertz A, Geissler-Plaum R, et al. Bacterial Species Associated with Highly Allergenic Plant Pollen Yield a High Level of Endotoxins and Induce Chemokine and Cytokine Release from Human A549 Cells. Inflammation. 2022;45(6):2186–2201.
  18. Berger M, Bastl M, Bouchal J, Dirr L, Berger U. The influence of air pollution on pollen allergy sufferers. Allergologie Select. 2021;5:345.
  19. Aguilera J, Ibarra-Mejia G, Johnson M. Editorial: The impact of climate change on allergic disease. Front. Allergy. 2023;4:1246899.
  20. Liu SH, Kazemi S, Karrer G, Bellaire A, Weckwerth W, Damkjaer J, et al. Influence of the environment on ragweed pollen and their sensitizing capacity in a mouse model of allergic lung inflammation. Front Allergy. 2022 Aug 5;3:854038.
  21. Keeling CD, Piper SC. Exchanges of atmospheric CO2 and 13CO2 with the terrestrial biosphere and oceans from 1978 to 2000. IV. Critical Overview. Date last accessed: 23 November 2023. Date last updated: June 2001.
  22. Zhang Y, Steiner AL. Projected climate-driven changes in pollen emission season length and magnitude over the continental United States. Nat Commun. 2022;13(1):1234.
  23. Ziska LH, Beggs PJ. Anthropogenic climate change and allergen exposure: The role of plant biology. J Allergy Clin Immunol. 2012 Jan;129(1):27–32.
  24. US Environmental Protection Agency. Trends in ozone adjusted for weather conditions. https://www.epa.gov/air-trends/trends-ozone-adjusted-weather-conditions. Accessed July 21, 2023.
  25. Asthma and Allergy Foundation of America. Allergy Capitals: the most challenging places to live with allergies. Available at: https://www.aafa.org/wp-content/ uploads/2022/08/aafa-2022-allergy-capitals-report.pdf. Accessed July 22, 2023.
  26. Blando J, Bielory L, Nguyen-Feng VN, Diaz R, Jeng HA. Anthropogenic Climate Change and Allergic Diseases. Atmosphere. 2012;3(1):200–212. https://doi.org/10.3390/atmos301020083
  27. Zhang Y, Steiner AL. Projected climate-driven changes in pollen emission season length and magnitude over the continental United States. Nat Commun. 2022;13:1234.
  28. D’Amato G, Chong-Neto HJ, Monge Ortega OP, et al. The effects of climate change on respiratory allergy and asthma induced by pollen and mold allergens. Allergy. 2020;75:2219–2228.
  29. Organisation for Economic Co-operation and Development. Environmental outlook to 2050: the consequences of inaction. Date last accessed: 26 January 2024. Date last updated: March 2012. oecd.org/environment/indicators-modelling-outlooks/49928853.pdf
  30. Kotsyfakis M, Zarogiannis SG, Patelarou E. The health impact of Saharan dust exposure. Int J Occup Med Environ Health. 2019;32:749–760.
  31. Su K-W, Chiu C-Y, Tsai M-H, et al. Asymptomatic toddlers with house dust mite sensitization at risk of asthma and abnormal lung functions at age 7 years. World Allergy Organ J 2019;12: 100056.
  32. Aggarwal P, Senthilkumaran S. Dust Mite Allergy. Treasure Island, StatPearls Publishing; 2023.
  33. Miller JD. The role of dust mites in allergy. Clin Rev Allergy Immunol. 2018;57:312–329.
  34. Maciag MC, Phipatanakul W. Update on indoor allergens and their impact on pediatric asthma. Ann Allergy Asthma Immunol. 2022;128:652–658.
  35. Kanchongkittiphon W, Mendell MJ, Gaffin JM, et al. Indoor environmental exposures and exacerbation of asthma: an update to the 2000 review by the Institute of Medicine. Environ Health Perspect. 2015;123:6–20.
  36. Guarnieri M, Balmes JR. Outdoor air pollution and asthma. Lancet. 2014;383(9928):1581–1592.
  37. Celebi Sozener Z, Ozdel Ozturk B, Cerci P, Turk M, Gorgulu Akin B, Akdis M, et al. Epithelial barrier hypothesis: effect of the external exposome on the microbiome and epithelial barriers in allergic disease. Allergy. 2022;77(5):1418–1449.
  38. Pan Z, Dai Y, Akar-Ghibril N, Simpson J, Ren H, Zhang L, et al. Impact of air pollution on atopic dermatitis: a comprehensive review [e-pub ahead of print]. Clin Rev Allergy Immunol.
  39. Yang L, Li C, Tang X. The impact of PM(2.5) on the host defense of respiratory system. Front Cell Dev Biol. 2020;8:91.
  40. Liu L, Urch B, Poon R, Szyszkowicz M, Speck M, Gold DR, et al. Effects of ambient coarse, fine, and ultrafine particles and their biological constituents on systemic biomarkers: a controlled human exposure study. Environ Health Perspect. 2015;123(6):534–540.
  41. Seastedt H, Nadeau K. Factors by which global warming worsens allergic disease. Ann Allergy Asthma Immunol. 2023 Dec;131(6):694–702.
  42. Bromberg PA. Mechanisms of the acute effects of inhaled ozone in humans. Biochim Biophys Acta. 2016;1860(12):2771–2781.
  43. Wijngaard RR, van der Perk M, van der Grift B, de Nijs TCM, Bierkens MFP. The impact of climate change on metal transport in a lowland catchment. Water Air Soil Pollut. 2017;228(3):107.
  44. Oyewo OA, Adeniyi A, Bopape MF. In Climate Change and Soil Interactions. Prasad, M. N. V. & Pietrzykowski, M., eds. Elsevier, 2020. pp. 51−88. https://doi.org/ 10.1016/B978-0-12-818032-7.00004-7.
  45. Rahman A, Islam MS, Tony SR, Siddique AE, Mondal V, Hosen Z, et al. T helper 2- driven immune dysfunction in chronic arsenic-exposed individuals and its link to the features of allergic asthma. Toxicol Appl Pharmacol. 2021;420:115532.
  46. Carreras-Sospedra M, Zhu S, MacKinnon, M, et al. Air quality and health impacts of the 2020 wildfires in California. Fire Ecol. 2024;20:6. https://doi.org/10.1186/s42408-023-00234-y
  47. Global Climate Change, A Force of Nature: Hurricanes in a Changing Climate. 2022.
  48. Kevat A. Thunderstorm Asthma: Looking Back and Looking Forward, J Asthma Allergy. 2020;13:293–299.
  49. D’Amato G, Vitale C, D’Amato M, Cecchi L, Liccardi G, Molino A, et al. Thunderstorm-related asthma: what happens and why. Clin Exp Allergy. 2016;46(3):390–396.
  50. Suphioglu C, Singh MB, Taylor P, et al. Mechanism of grass-pollen-induced asthma. Lancet. 1992; 339:569–572.
  51. O’Hehir RE, Varese NP, Deckert K, et al. Epidemic thunderstorm asthma protection with five-grass pollen tablet sublingual immunotherapy: a clinical trial. Am J Respir Crit Care Med. 2018;198: 126–128.
  52. Hughes DD, Mampage CBA, Jones LM, et al. Characterization of atmospheric pollen fragments during springtime thunderstorms. Environ Sci Technol Lett. 2020;7:409–414.
  53. Bouchama A, Knochel JP, Heat Stroke, New Eng J Med 2002;346(25):1978–1988.
  54. Heled Y, Fleischmann C, Epstein Y, Cytokines and their role in hyperthermia and heat stroke, J Basic Clin Physiol Pharmacol. 2013;24(2):85–96.
  55. Liu YL, Ding KN, Shen XL, Liu HX, Zhang YA, Liu YQ, et al. Chronic heat stress promotes liver inflammation in broilers via enhancing NF-κB and NLRP3 signaling pathway, BMC Vet Res. 2022; 18(1):289.
  56. de Punder K, Pruimboom L. Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability, Front Immunol. 2015;6:223. [PubMed: 26029209].
  57. León B. Understanding the development of Th2 cell-driven allergic airway disease in early life. Front Allergy. 2023;3:1080153.
  58. Ege MJ, Mayer M, Normand A-C, et al. Exposure to environmental microorganisms and childhood asthma. N Engl J Med. 2011;364:701–709.
  59. Perera F, Nadeau K. Climate change, fossil-fuel pollution, and children’s health. N Engl J Med. 2022;386:2303–2314.
  60. Buchholz V, Bridgman SL, Nielsen CC, et al. Natural green spaces, sensitization to allergens, and the role of gut microbiota during infancy. mSystems. 2023;8:e0119022.
  61. Coulburn L, Miller W. Prevalence, risk factors and impacts related to mould-affected housing: an Australian integrative review. Int J Environ Res Public Health. 2022;19:1854.
  62. Mirsaeidi M, Motahari H, Taghizadeh Khamesi M, et al. Climate change and respiratory infections. Ann Am Thorac Soc. 2016;13:1223–1230.
  63. Helldén D, Andersson C, Nilsson M, et al. Climate change and child health: a scoping review and an expanded conceptual framework. Lancet Planet Health. 2021;5:e164–e175.
  64. Burbank AJ. Risk factors for respiratory viral infections: a spotlight on climate change and air pollution. J Asthma Allergy. 2023;16:183–194.
  65. Anderegg WRL, Abatzoglou JT, Anderegg LDL, Bielory L, Kinney PL, Ziska L. Anthropogenic climate change is worsening North American pollen seasons. Proc Natl Acad Sci USA. 2021;118(7):e2013284118.
Regular Issue Subscription Original Research
Volume 15
Issue 01
Received 01/11/2024
Accepted 11/11/2024
Published 07/02/2025
75