The Prognostic Efficacy of Inflammatory Indicators in Determining the Cause of Multiple Sclerosis Exacerbation

Year : 2025 | Volume : 15 | Issue : 01 | Page : 1 8
    By

    Rajiv Shrestha,

  1. Registrar, Civil Service Hospital, Kathmandu, Nepal

Abstract

Multiple sclerosis (MS) is the most prevalent immune-mediated inflammatory disease affecting the central nervous system, presenting with diverse clinical symptoms and manifestations. This study investigates the diagnostic potential of the monocyte-to-lymphocyte ratio (MLR), red cell distribution width-to-lymphocyte ratio (RLR), and systemic immune-inflammation index (SII) in detecting MS attacks among relapsing-remitting MS (RRMS) patients seeking care in the emergency department (ED). The research focused on RRMS patients who presented to the ED, analyzing data from 165 individuals. The inflammatory biomarker values were compared between periods of attack and non-attack using paired t-tests to determine the differences between the two groups. Patients who experienced an MS attack had greater mean values for the neutrophil/lymphocyte ratio (NLR), MLR, RLR, and SII than those who did not. The two groups’ respective mean differences in NLR, MLR, RLR, and SII were 5.40 ± 7.25,0.37 ± 0.43,7.77 ± 11.61, and 1469.19 ± 1978.88(p < 0.001). NLR, RLR, MLR, and SII showed superior diagnostic ability in identifying MS relapse in ROC analysis (AUC:0.87,0.81,0.86, and 0.87,respectively).Our results suggest that SII, MLR, NLR, and RLR could be useful in helping patients with RRMS confirm their diagnosis of attack.

Keywords: Inflammatory biomarker, Monocyte-to-Lymphocyte Ratio, Multiple Sclerosis, Neutrophil-to-Lymphocyte Ratio, Systemic Immune Inflammation Index, Red Cell Distribution Width-to-Lymphocyte Ratio

[This article belongs to Research and Reviews : A Journal of Immunology ]

How to cite this article:
Rajiv Shrestha. The Prognostic Efficacy of Inflammatory Indicators in Determining the Cause of Multiple Sclerosis Exacerbation. Research and Reviews : A Journal of Immunology. 2025; 15(01):1-8.
How to cite this URL:
Rajiv Shrestha. The Prognostic Efficacy of Inflammatory Indicators in Determining the Cause of Multiple Sclerosis Exacerbation. Research and Reviews : A Journal of Immunology. 2025; 15(01):1-8. Available from: https://journals.stmjournals.com/rrjoi/article=2025/view=194180


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Regular Issue Subscription Original Research
Volume 15
Issue 01
Received 27/12/2024
Accepted 29/12/2024
Published 15/01/2025
Publication Time 19 Days
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