Phytochemical, Pharmacological and Toxicological Studies of Solanum americanum: A Systemic Review

Year : 2025 | Volume : 14 | Issue : 02 | Page : 52 62
    By

    Sinthia Parvez,

  • Most. Nazma Parvin,

  1. Student, Bachelor of Pharmacy (Honors), Department of Pharmacy, Stamford University Bangladesh, Dhaka, , Bangladesh
  2. Associate Professor, Department of Pharmacy, Stamford University Bangladesh, Dhaka, , Bangladesh

Abstract

Solanum americanum, a plant widely used in folk medicine, has recently gained attention in the scientific community due to its diverse therapeutic potential. The bioactive compounds found in different plant parts, such as alkaloids, flavonoids, and tannins, have significant medicinal effects. These compounds exhibit several pharmacological properties, such as antimicrobial, anti-inflammatory, anticancer, and antioxidant effects. However, despite these medicinal benefits, some compounds show significant toxicity to the human body if taken at a high dosage. For example, solanine, one of the glycoalkaloids found in the plant’s unripe fruits and leaves, can exert significant toxicity by disrupting the cell membranes of the gastrointestinal tract, leading to nausea, vomiting, diarrhea, and abdominal pain. This dual character highlights the necessity of exact dosage and thorough processing in order to maximize its medicinal benefits safely. In this article, we review the therapeutic potential and toxicological concerns of Solanum americanum, shedding light on its pharmacological properties, mechanisms of action, and associated risks. This comprehensive analysis aims to provide a balanced perspective, emphasizing the importance of controlled usage and further research to unlock its full medicinal potential while minimizing its adverse effects.

Keywords: Solanum americanum, folk medicine, solanine, glycoalkaloids.

[This article belongs to Research & Reviews : Journal of Herbal Science ]

How to cite this article:
Sinthia Parvez, Most. Nazma Parvin. Phytochemical, Pharmacological and Toxicological Studies of Solanum americanum: A Systemic Review. Research & Reviews : Journal of Herbal Science. 2025; 14(02):52-62.
How to cite this URL:
Sinthia Parvez, Most. Nazma Parvin. Phytochemical, Pharmacological and Toxicological Studies of Solanum americanum: A Systemic Review. Research & Reviews : Journal of Herbal Science. 2025; 14(02):52-62. Available from: https://journals.stmjournals.com/rrjohs/article=2025/view=208181


References

  1. David B, Wolfender JL, Dias DA. The pharmaceutical industry and natural products: historical status and new trends. Phytochem Rev. 2015;14:299–315.
  2. Shah VV, Shah ND, Patrekar Medicinal plants from Solanaceae family. Res J Pharm Technol. 2013;6(2):143–151.
  3. Lim Edible medicinal and non-medicinal plants. Dordrecht (Netherlands): Springer; 2012.
  4. Murugan P, Kalidass C, Panda A new variety of Solanum americanum Mill. (Solanaceae), from Eastern Ghats, India. Bangladesh J Plant Taxon. 2016;23(1):83.
  5. Knapp S, Barboza GE, Bohs L, Särkinen T. A revision of the Morelloid clade of Solanum (Solanaceae) in North and Central America and the Caribbean. PhytoKeys. 2019;123:1.
  6. O’Connor-Sánchez A, Domínguez-May ÁV, Keb-Llanes MA, et al. Efficient plant regeneration from leaf explants of Solanum americanum. Afr J Biotechnol. 2010;9(36).
  7. Akbar S, Akbar S. Solanum americanum (Solanaceae) (Syns.: S. nigrum L.; S. nigrum auct. non L.; S. caribaeum Dunal). In: Handbook of 200 Medicinal Plants: A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications. 2020;1673–1684.
  8. Asante JO, Oduro I, Wireko-Manu F, et al. Assessment of the antioxidant and nutritive profile of the leaves and berries of Solanum nigrum and Solanum torvum Appl Food Res. 2024;20:100438.
  9. Gaffield W, Keeler RF, Baker DC. Solanum glycoalkaloids: plant toxins possessing disparate physiologically active structural entities. In: Handbook of natural toxins. Boca Raton: CRC Press; 2024. pp. 135–158.
  10. Fawzi NM, Habeeb Taxonomic study on the wild species of genus Solanum L. in Egypt. Ann Agric Sci. 2016;61(2):165–173.
  11. Elizalde-Romero CA, Montoya-Inzunza LA, Contreras-Angulo LA, et al. Solanum fruits: phytochemicals, bioaccessibility and bioavailability, and their relationship with their health- promoting effects. Front Nutr. 2021;8:790582.
  12. Almoulah NF, Voynikov Y, Gevrenova R, et al. Antibacterial, antiproliferative and antioxidant activity of leaf extracts of selected Solanaceae species. S Afr J Bot. 2017;112:368–374.
  13. Cunha SC, Fernandes JO. Extraction techniques with deep eutectic solvents. TrAC Trends Anal Chem. 2018;105:225–239.
  14. Božović M, Navarra A, Garzoli S, et al. Essential oils extraction: A 24-hour steam distillation systematic methodology. Nat Prod Res. 2017;31(20):2387–2396.
  15. Da Silva RP, Rocha-Santos TA, Duarte Supercritical fluid extraction of bioactive compounds. TrAC Trends Anal Chem. 2016;76:40–51.
  16. Xie F, Zhang TA, Dreisinger D, et al. A critical review on solvent extraction of rare earths from aqueous solutions. Miner Eng. 2014;56:10–28.
  17. Parliment TH. Solvent extraction and distillation techniques. In: Techniques for analyzing food 2020. 1–26.
  18. Herrero M, Mendiola JA, Cifuentes A, et al. Supercritical fluid extraction: Recent advances and applications. J Chromatogr A. 2010;1217(16):2495–2511.
  19. Yuan B, Byrnes D, Giurleo D, et Rapid screening of toxic glycoalkaloids and micronutrients in edible nightshades (Solanum spp.). J Food Drug Anal. 2018;26(2):751–760.
  20. Hassan SH, Gul S, Zahra HS, et Alpha solanine: A novel natural bioactive molecule with anticancer effects in multiple human malignancies. Nutr Cancer. 2021;73(9):1541–1552.
  21. Šutković J, Ler D, Gawwad In vitro production of solasodine alkaloid in Solanum nigrum under salinity stress. J Phytol. 2011;3(1).
  22. Sucha L, Tomsik The steroidal glycoalkaloids from Solanaceae: toxic effect, antitumour activity and mechanism of action. Planta Med. 2016;82(5):379–387.
  23. Usman H, Victor V, Waziri Qualitative phytochemical screening and in vitro antimicrobial activities of Solanum americanum Mill. Arid Zone J Eng Technol Environ. 2018;14(1):104–110.
  24. Valya G, Ragan A, Raju Screening for in vitro antimicrobial activity of Solanum americanum Miller. J Recent Adv Appl Sci. 2011;26.
  25. Patel RV, Mistry BM, Shinde SK, et Therapeutic potential of quercetin as a cardiovascular agent. Eur J Med Chem. 2018;155:889–904.
  26. Senizza B, Rocchetti G, Sinan KI, et The phenolic and alkaloid profiles of Solanum erianthum and Solanum torvum modulated their biological properties. Food Biosci. 2021;41:100974.
  27. Li K, Diao Y, Zhang H, Wang S, et Tannin extracts from immature fruits of Terminalia chebula Fructus Retz. promote cutaneous wound healing in rats. BMC Complement Med Ther. 2011;11:1– 9.
  28. Al Sinani SS, Eltayeb The steroidal glycoalkaloids solamargine and solasonine in Solanum plants. S Afr J Bot. 2017;112:253–269.
  29. Sharma T, Gamit R, Acharya R, et al. Quantitative estimation of total tannin, alkaloid, phenolic, and flavonoid content of the root, leaf, and whole plant of Byttneria herbacea AYU. 2021;42(3):143–147.
  30. Lahare RP, Yadav HS, Bisen YK, et al. Estimation of total phenol, flavonoid, tannin and alkaloid content in different extracts of Catharanthus roseus from Durg district, Chhattisgarh, India. Scholars Bull. 2021;7(1):1–6.
  31. Kaunda JS, Zhang The genus Solanum: an ethnopharmacological, phytochemical and biological properties review. Nat Prod Bioprospect. 2019;9(2):77–137.
  32. Raji P, Samrot AV, Keerthana D, et Antibacterial activity of alkaloids, flavonoids, saponins and tannins mediated green synthesised silver nanoparticles against Pseudomonas aeruginosa and Bacillus subtilis. J Clust Sci. 2019;30:881–895.
  33. HL R, MR R, HC A, et Antimicrobial, insecticidal, and antiradical activity of Solanum virginianum L. (Solanaceae). Asian J Pharm Clin Res. 2017;10(11):163–167.
  34. Ahamad J, Uthirapathy S, Anwer ET, et Glycoalkaloids as food toxins. In: Analysis of Naturally Occurring Food Toxins of Plant Origin. CRC Press; 2022. 81–94.
  35. Lu MK, Shih YW, Chien TT, et al. α-Solanine inhibits human melanoma cell migration and invasion by reducing matrix metalloproteinase-2/9 Biol Pharm Bull. 2010;33(10):1685– 1691.
  36. Winkiel MJ, Chowański S, Słocińska Anticancer activity of glycoalkaloids from Solanum plants: A review. Front Pharmacol. 2022;13:979451.
  37. Manoharan R, Nair CS, Eissa N, et al. Therapeutic potential of Solanum alkaloids with special emphasis on cancer: a comprehensive review. Drug Des Devel Ther. 2024:3063–3074.
  38. Hameed A, Ijaz S, Mohammad IS, et A glycone solanidine and solasodine derivatives: A natural approach towards cancer. Biomed Pharmacother. 2017;94:446–457.
  39. Shen KH, Hung JH, Chang CW, et al. Solasodine inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs Chem Biol Interact. 2017;268:129–135.
  40. Zhuang YW, Wu CE, Zhou JY, et al. Solasodine inhibits human colorectal cancer cells through suppression of the AKT/glycogen synthase kinase-3β/β-catenin pathway. Cancer Sci. 2017;108(11):2248–2264.
  41. Lesjak M, Beara I, Simin N, et Antioxidant and anti-inflammatory activities of quercetin and its derivatives. J Funct Foods. 2018;40:68–75.
  42. Hanáková Z, Hosek J, Kutil Z, et Anti-inflammatory activity of natural geranylated flavonoids: cyclooxygenase and lipoxygenase inhibitory properties and proteomic analysis. J Nat Prod. 2017;80(4):999–1006.
  43. Bhaskar S, Shalini V, Helen A. Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-κB signaling pathway. Immunobiology. 2011;216(3):367–373.
  44. Baghel SS, Shrivastava N, Baghel RS, et al. A review of quercetin: antioxidant and anticancer properties. World J Pharm Pharm Sci. 2012;1(1):146–160.
  45. Dong Y, Hou Q, Lei J, et Quercetin alleviates intestinal oxidative damage induced by H2O2 via modulation of GSH: in vitro screening and in vivo evaluation in a colitis model of mice. ACS Omega. 2020;5(14):8334–8346.
  46. Sadiq Free radicals and oxidative stress: Signaling mechanisms, redox basis for human diseases, and cell cycle regulation. Curr Mol Med. 2023;23(1):13–35.
  47. Natarajan V, Krithica N, Madhan B, et al. Preparation and properties of tannic acid cross‐linked collagen scaffold and its application in wound healing. J Biomed Mater Res B Appl Biomater. 2013;101(4):560–567.
  48. Baldwin A, Booth Biomedical applications of tannic acid. J Biomater Appl. 2022;36(8):1503– 1523.
  49. Kaczmarek B. Tannic acid with antiviral and antibacterial activity as a promising component of biomaterials—A minireview. Materials (Basel). 2020;13(14):3224.
  50. Song Y, Luo Y, Yu B, et Tannic acid extracted from gallnut prevents post-weaning diarrhea and improves intestinal health of weaned piglets. Anim Nutr. 2021;7(4):1078–1086.
  51. Yang X, Xiong X, Wang H, et al. Protective effects of Panax notoginseng saponins on cardiovascular diseases: a comprehensive overview of experimental studies. Evid Based Complement Alternat Med. 2014;2014:204840.
  52. Baker DC, Keeler RF, Gaffield W. Toxicosis from steroidal alkaloids of Solanum In: Handbook of Natural Toxins. CRC Press; 2024. 71–82.
  53. AL O, EX F, Rimental P, et Solanine poisoning: effects, risks, and management strategies. J Exp Basic Med Sci. 2024;5(2):189–193.
  54. Zhao L, Wang L, Di SN, et al. Steroidal alkaloid solanine A from Solanum nigrum exhibits anti-inflammatory activity in lipopolysaccharide/interferon γ-activated murine macrophages and animal models of inflammation. Biomed Pharmacother. 2018;105:606–615.
  55. Milner SE, Brunton NP, Jones PW, et Bioactivities of glycoalkaloids and their aglycones from Solanum species. J Agric Food Chem. 2011;59(8):3454–3484.
  56. Ostreikova TO, Kalinkina OV, Bogomolov NG, et al. Glycoalkaloids of plants in the family Solanaceae (Nightshade) as potential drugs. Pharm Chem J. 2022;56(7):948–957.
  57. Jain R, Sharma A, Gupta S, et al. Solanum nigrum: current perspectives on therapeutic properties. Altern Med Rev. 2011;16(1):78–85.
  58. Chen Y, Li S, Sun F, et In vivo antimalarial activities of glycoalkaloids isolated from Solanaceae plants. Pharm Biol. 2010;48(9):1018–1024.
  59. Delbrouck JA, Desgagné M, Comeau C, et The therapeutic value of Solanum steroidal (glyco)alkaloids: a 10-year comprehensive review. Molecules. 2023;28(13):4957.
Regular Issue Subscription Review Article
Volume 14
Issue 02
Received 19/02/2025
Accepted 29/03/2025
Published 01/04/2025
Publication Time 41 Days
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