Development and Optimization of Orally Disintegrating Tablets (ODTs) Containing Standardized Curcumin Extract for Enhanced Bioavailability and Patient Compliance

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nThis is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.n

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Year : 2025 [if 2224 equals=””]11/10/2025 at 9:10 PM[/if 2224] | [if 1553 equals=””] Volume : 12 [else] Volume : 12[/if 1553] | [if 424 equals=”Regular Issue”]Issue : [/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] 03 | Page : 1 06

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    Rupesh Kumar Pandey, Kamalesh Mistry, Dhananjay Mistry, Shivam Rongpi, Pratyush Kumar Brahma, Mitul Bhoi,

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  1. Research Scholar, Assistant Professor, Lecturer, Assistant Professor, Assistant Professor, Assistant Professor, Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh, Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh, Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh, Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh, School of Pharmacy, Rai University, Dholka, Ahmedabad, School of Pharmacy, Rai University, Dholka, Ahmedabad, Rajasthan, Rajasthan, Rajasthan, Rajasthan, Gujarat, Gujarat, India, India, India, India, India, India

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nThis research centers on creating and perfecting orally disintegrating tablets with standardized curcumin extract to both increase its bioavailability and promote better patient adherence. Although curcumin has numerous therapeutic applications. It remains clinically ineffective due to its poor aqueous solubility and bioavailability constraints. The development of orally disintegrating tablets involved direct compression with various levels of superdisintegrants including sodium starch glycolate and cross povidone to address existing challenges. Research teams developed five distinct formulations known as F1–F5 and conducted evaluations on pre-compression parameters together with postcompression quality attributes as well as in vitro disintegration, drug release, and short-term stability. Batch F5 outperformed all other samples by achieving a disintegration time of 27 ± 1 seconds and releasing 94.1 ± 0.8% of the drug within 30 minutes. All powder blends exhibited optimal flow properties while each tablet successfully met the required pharmacopeial standards. Accelerated storage condition tests demonstrated the optimized batch-maintained stability. The results indicate standardized curcumin extract ODTs using crospovidone as superdisintegrants offer a beneficial delivery method that improves curcumin’s therapeutic effects in patients facing swallowing challenges.This research centers on creating and perfecting orally disintegrating tablets with standardized curcumin extract to both increase its bioavailability and promote better patient adherence. Although curcumin has numerous therapeutic applications. It remains clinically ineffective due to its poor aqueous solubility and bioavailability constraints. The development of orally disintegrating tablets involved direct compression with various levels of superdisintegrants including sodium starch glycolate and cross povidone to address existing challenges. Research teams developed five distinct formulations known as F1–F5 and conducted evaluations on pre-compression parameters together with postcompression quality attributes as well as in vitro disintegration, drug release, and short-term stability. Batch F5 outperformed all other samples by achieving a disintegration time of 27 ± 1 seconds and releasing 94.1 ± 0.8% of the drug within 30 minutes. All powder blends exhibited optimal flow properties while each tablet successfully met the required pharmacopeial standards. Accelerated storage condition tests demonstrated the optimized batch-maintained stability. The results indicate standardized curcumin extract ODTs using crospovidone as superdisintegrants offer a beneficial delivery method that improves curcumin’s therapeutic effects in patients facing swallowing challenges.nn

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Keywords: Curcumin extract, orally disintegrating tablets (odts), superdisintegrants, bioavailability, crospovidone, direct compression, patient compliance

n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Drug Formulation, Development and Production ]

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nRupesh Kumar Pandey, Kamalesh Mistry, Dhananjay Mistry, Shivam Rongpi, Pratyush Kumar Brahma, Mitul Bhoi. [if 2584 equals=”][226 wpautop=0 striphtml=1][else]Development and Optimization of Orally Disintegrating Tablets (ODTs) Containing Standardized Curcumin Extract for Enhanced Bioavailability and Patient Compliance[/if 2584]. Research & Reviews: A Journal of Drug Formulation, Development and Production. 11/10/2025; 12(03):1-06.

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nRupesh Kumar Pandey, Kamalesh Mistry, Dhananjay Mistry, Shivam Rongpi, Pratyush Kumar Brahma, Mitul Bhoi. [if 2584 equals=”][226 striphtml=1][else]Development and Optimization of Orally Disintegrating Tablets (ODTs) Containing Standardized Curcumin Extract for Enhanced Bioavailability and Patient Compliance[/if 2584]. Research & Reviews: A Journal of Drug Formulation, Development and Production. 11/10/2025; 12(03):1-06. Available from: https://journals.stmjournals.com/rrjodfdp/article=11/10/2025/view=0

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  1. RaviKKumar VR, Rathi S, Singh S, Patel B, Singh S, Chaturvedi K, et al. A comprehensive review on ulcer and their treatment. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2023 Dec 21;39:e20230006. doi: 10.62958/j.cjap.2023.006. PMID: 38755116.
  2. Singh V, Arora S, Akram W, Alam S, Kumari L, Kumar N, et al. Involvement of molecular mechanism and biological activities of Pemirolast: A therapeutic review. New Emirates Med J. 2024;5:e02506882308410. doi: 10.2174/0102506882308410240607053814.
  3. Rajput DS, Gupta N, Singh S, Sharma B. A comprehensive review: Personalized medicine for rare disease cancer treatment. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2023 Dec 23;39:e20230008. doi: 10.62958/j.cjap.2023.008. PMID: 38830754.
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  5. Kumar S, Saha S, Sharma B, Singh S, Shukla P, Mukherjee S, et al. The role of resveratrol in Alzheimer’s disease: A comprehensive review of current research. Curr Funct Foods. 2023;2(2):e121223224364. doi: 10.2174/0126668629269244231127071411.
  6. Patel S, Ismail Y, Singh S, Rathi S, Shakya S, Patil SS, et al. Recent innovations and future perspectives in transferosomes for transdermal drug delivery in therapeutic and pharmacological applications. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2024 Oct 24;40:e20240031. doi: 10.62958/j.cjap.2024.031. PMID: 39442957.
  7. Vaghela MC, Rathi S, Shirole RL, Verma J, Shaheen, Panigrahi S, et al. Leveraging AI and machine learning in Six-Sigma documentation for pharmaceutical quality assurance. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2024 Jul 18;40:e20240005. doi: 10.62958/j.cjap.2024.005. PMID: 39019923.
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  9. Kumar S, Saha S, Pathak D, Singh T, Kumar A, Singh K, et al. Cholesterol absorption inhibition by some nutraceuticals. Recent Adv Food Nutr Agric. 2024;16(1):2–11. doi: 10.2174/012772574X285280240220065812.
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  11. Kumar S, Singh S, Rajput D, Sharma B, Chaturvedi K, Singh N, et al. Pharmacological approaches and herbal interventions for Alzheimer’s disease. Nat Prod J. 2024;14(8):e220124225945. doi: 10.2174/0122103155275266231123090138.
  12. Ravikkumar VR, Patel BD, Rathi S, Parthiban S, Upadhye MC, Shah AM, et al. Formulation and evaluation of drumstick leaves tablet as an immunomodulator. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2024 Jun 21;40:e20240004. doi: 10.62958/j.cjap.2024.004. PMID: 38902996.
  13. Sharma A, Bara G, Keshamma E, Sharma B, Singh S, Singh SP, et al. Cancer biology and therapeutics: A contemporary review. J Cardiovasc Dis Res. 2023;14(10):1229–47.
  14. Dewangan HK, Singh S, Mishra R, Dubey RK. A review on application of nanoadjuvant as delivery system. Int J Appl Pharm. 2020;12(4):24–33. doi: 10.22159/ijap.2020v12i4.36856.
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  16. Patel SK, Prathyusha S, Kasturi M, Godse KC, Singh R, Rathi S, et al. Optimizing Irbesartan fast dissolving tablets using natural polysaccharides for enhanced drug delivery and patient compliance. Int Res J Multidiscip Scope. 2025;6(1):1181–90. doi: 10.47857/irjms.2025.v06i01.02542.

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[if 424 not_equal=””]Regular Issue[else]Published[/if 424] Subscription Original Research

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Volume 12
[if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] 03
Received 14/04/2025
Accepted 28/05/2025
Published 11/10/2025
Retracted
Publication Time 180 Days

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