A Thorough Analysis of Herbal and Synthetic Methods for Treating Peptic Ulcers

Year : 2025 | Volume : 12 | Issue : 02 | Page : 55 71
    By

    Avi Baliyan,

  • Manisha Thakur,

  • Renu Dwivedi,

  • Ashish Sharma,

  1. Student, School of Pharmaceutical Sciences, Bahra University, Waknaghat, Himachal Pradesh, India
  2. Student, School of Pharmaceutical Sciences, Bahra University, Waknaghat, Himachal Pradesh, India
  3. Assistant Professor, School of Pharmaceutical Sciences, Bahra University, Waknaghat, Himachal Pradesh, India
  4. Student, School of Pharmaceutical Sciences, Bahra University, Waknaghat, Himachal Pradesh, India

Abstract

Many people are afflicted with ulcers, a common gastrointestinal disorder. In essence, they are inflammatory lesions that form in the digestive tract’s skin or mucous membrane lining. An imbalance between preventive and damaging factors—either from reduced mucosal defences or from increased aggressive elements—leads to ulcer development. Their development is influenced by a number of variables, including as stress, poor eating habits, and long-term pharmaceutical use. The word “peptic ulcers” refers to ulcers that mostly occur in the digestive system, specifically in the stomach or duodenum. Pepsin activity, the breakdown of mucosal defences, and the presence of stomach acid all affect their growth. Although there are a number of synthetic medications available to treat ulcers, they are frequently expensive and linked to possible negative effects, making herbal remedies a more appealing choice. Reducing discomfort, encouraging ulcer healing, and avoiding recurrence should be the main goals of the best peptic ulcer management strategy. This article examines typical medicinal plants used to treat and prevent ulcers in both modern and Ayurvedic medicine. Furthermore, it emphasizes easy and natural ways to use these herbs to effectively treat ulcers.

Keywords: Peptic ulcer, Medicinal plants, antiulcer activity, herbal drugs, medicinal Herbs, Patents.

[This article belongs to Research & Reviews: A Journal of Drug Formulation, Development and Production ]

How to cite this article:
Avi Baliyan, Manisha Thakur, Renu Dwivedi, Ashish Sharma. A Thorough Analysis of Herbal and Synthetic Methods for Treating Peptic Ulcers. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2025; 12(02):55-71.
How to cite this URL:
Avi Baliyan, Manisha Thakur, Renu Dwivedi, Ashish Sharma. A Thorough Analysis of Herbal and Synthetic Methods for Treating Peptic Ulcers. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2025; 12(02):55-71. Available from: https://journals.stmjournals.com/rrjodfdp/article=2025/view=222018


References

  1. Lau JY, Sung J, Hill C, Henderson C, Howden CW, Metz DC. Systematic review of the epidemiology of complicated peptic ulcer disease: Incidence, recurrence. Digestion. 2011;84(2):102–13.
  2. Kumar R. A review on medicinal plants for peptic ulcer. Der Pharm Lett. 2011;3:414–20.
  3. Patel G, Jain S. Antiulcer activity of Nerium indicum in rats. Res J Pharmacol. 2010;4(3):66–8.
  4. Pension J, Wormsley KG. Adverse reactions and interactions with H2-receptor antagonists. Med Toxicon. 1986;1:192–216.
  5. Mossner J. The indications, applications, and risks of proton pump inhibitors. Dtsch Arztebl Int. 2016;113:477–83.
  6. Maes ML, Fixen DR, Linnebur SA. Adverse effects of proton-pump inhibitor use in older adults: A review of the evidence. Ther Adv Drug Saf. 2017;8:273–97.
  7. Marks IN. Sucralfate-safety and side effects. Scand J Gastroenterol Suppl. 1991;26:36–42.
  8. Aubert J, Bejan-Angoulvant T, Jonville-Bera AP. Pharmacology of misoprostol (pharmacokinetic data, adverse effects and teratogenic effects). J Gynecol Obstet Biol Reprod (Paris). 2014;43:114–22.
  9. Mizokami Y, Oda K, Funao N, Nishimura A, Soen S, Kawai T, et al. Vonoprazan prevents ulcer recurrence during long-term NSAID therapy: Randomised, lansoprazole-controlled non-inferiority and single-blind extension study. Gut. 2018;67:1042–51.
  10. Yamasaki A, Yoshio T, Muramatsu Y, Horiuchi Y, Ishiyama A, Hirasawa T, et al. Vonoprazan is superior to rabeprazole for healing endoscopic submucosal dissection-induced ulcers. Digestion. 2018;97:170–6.
  11. Kawai T, Oda K, Funao N, Nishimura A, Matsumoto Y, Mizokami Y, et al. Vonoprazan prevents low-dose aspirin-associated ulcer recurrence: Randomised phase 3 study. Gut. 2018;67:1033–41.
  12. Maton PN, Burton ME. Antacids revisited: A review of their clinical pharmacology and recommended therapeutic use. Drugs. 1999;57:855–70.
  13. Song HJ, Kwon JW, Kim N, Park YS. Cost effectiveness associated with Helicobacter pylori screening and eradication in patients taking nonsteroidal anti-inflammatory drugs and/or aspirin. Gut Liver. 2013;7:182–9.
  14. Ford AC, Delaney BC, Forman D, Moayyedi P. Eradication therapy in Helicobacter pylori positive peptic ulcer disease: Systematic review and economic analysis. Am J Gastroenterol. 2004;99:1833–55.
  15. Singh J, Upadhyay AK, Bahadur A, Singh B, Singh KP, Rai M. Antioxidant phytochemicals in cabbage (Brassica oleracea L. var. capitata). Scientia Horticulturae. 2006 May 8;108(3):233-7.
  16. Nadkarni KM. Indian Materia Medica. Mumbai: Popular Prakashan; 1976. Vol. 1. p. 730–2.
  17. Choudhury SR, Roy S, Sengupta DN. A Ser/Thr protein kinase phosphorylates MAACS1 (Musa acuminata 1-aminocyclopropane-1-carboxylic acid synthase 1) during banana fruit ripening. Planta. 2012;236:491–511.
  18. Philip DC, Lavanya B, Sasirekha GV, Santhi M. Phytochemical screening, antioxidant and antidiabetic activity of Musa acuminata, Citrus sinensis and Phyllanthus emblica. Am J Pharm Tech Res. 2015;5:557–64.
  19. Nadkarni KM. Indian Materia Medica. Mumbai: Popular Prakashan; 1976. Vol. 1. p. 764–9.
  20. Zhang Z, Ge L, Lee ASY, Yong JWH, Tan SN, Ong ES. Simultaneous analysis of different classes of phytohormones in coconut (Cocos nucifera L.) water using high-performance liquid chromatography and liquid chromatography–tandem mass spectrometry after solid-phase extraction. Anal Chim Acta. 2008;610:274–81.
  21. Nadkarni KM. Indian Materia Medica. 1. Mumbai: Popular Prakashan; 1976. p. 662–6.
  22. Martins N, Barros L, Duenas M, Santos-Buelga C, Ferreira ICFR. Characterization of phenolic compounds and antioxidant properties of Glycyrrhiza glabra rhizomes and roots. RSC Adv. 2015;5:26991–7.
  23. Azamthulla M, Asad M, Prasad VS. Antiulcer activity of Allium sativum bulb juice in rats. Saudi Pharm J. 2009;17(1):70–7.
  24. Borra SK, Lagisetty RK, Mallela GR. Anti-ulcer effect of Aloe vera in nonsteroidal anti-inflammatory drug-induced peptic ulcer in rats. Afr J Pharm Pharmacol. 2011;5(16):1867–71.
  25. Kang JS, Kim SO, Kim GY, Hwang HJ, Kim BW, Chang YC, et al. An exploration of the antioxidant effects of garlic saponins in mouse-derived C2C12 myoblasts. Int J Mol Med. 2016;37:149–56.
  26. Kumar R. A review on medicinal plants for peptic ulcer. Der Pharm Lett. 2011;3(3):414–20.
  27. Islam MM, Wesonga R, Al Hasani I, Al Manei A. Prevalence and determinants of mental health issues among university students during COVID-19 pandemic in Oman: an online cross-sectional study. International Research Journal of Public and Environmental Health. 2022 Apr;9(2):43.
  28. Singh S, Majumdar DK. Evaluation of gastric antiulcer activity of fixed oil of Ocimum sanctum (Holy Basil). J Ethnopharmacol. 1999;65(1):13–9.
  29. Gregory M, Divya B, Mary RA, Hipolith Viji MM, Kalaichelvan VK, Palanivel V. Anti-ulcer activity of Ficus religiosa leaf ethanolic extract. Asian Pac J Trop Biomed. 2013;3(7):554–6.
  30. Joseph B, Justin SR. Phytopharmacological and phytochemical properties of three Ficus species: An overview. Int J Pharm Bio Sci. 2010;1(2).
  31. Khan MSA, Hussain SA, Jais AMM, Zakaria ZA, Khan M. Anti-ulcer activity of Ficus religiosa stem bark ethanolic extract in rats. J Med Plants Res. 2011;5(3):354–9.
  32. Vimala G, Gricilda Shobha F. A review on antiulcer activity of few Indian medicinal plants. Int J Microbiol. 2014;2014:519590.
  33. Balkrishna A. Secrets of Indian Herbs for Good Health. Haridwar: Divya Prakashan; Vol. 1. p. 228–31.
  34. Pinto LA, Cordeiro KW, Carrasco V, Carollo CA, Cardoso CA, Argadona EJ, et al. Antiulcerogenic activity of Carica papaya seed in rats. Naunyn Schmiedebergs Arch Pharmacol. 2015;388(3):305–17.
  35. Vimala G, Gricilda Shobha F. A review on antiulcer activity of few Indian medicinal plants. Int J Microbiol. 2014;2014:519590.
  36. Dhuley JN. Protective effect of Rhinax, a herbal formulation against physical and chemical factors induced gastric and duodenal ulcers in rats. Indian J Pharmacol. 1999;31:128–32.
  37. Manonmani S, Viswanathan VP, et al. Biochemical studies on the anti-ulcerogenic activity of Cauvery 100, an Ayurvedic formulation in experimental ulcers. Indian J Pharmacol. 1995;27:101–5.
  38. Datta GK, Sairam K, Priyambada S, Debnath PK, Goel RK. Antiulcerogenic activity of Satavari Mandur—an Ayurvedic herbo-mineral preparation. Indian J Exp Biol. 2002;40(10):1173–7.
  39. Carvalho CA, Silva MB, Oliveira TG, Lima JM, Rosa MB. Spectrometric study at different phenologic stages of the cabbage (Brassica oleracea var. capitata). Rev Bras Farmacogn. 2008;18:249–57.
  40. Silva Jr AA, Miura L, Yokoyama S. Repolho: Novas cultivares de verão. Agrop Catarinense. 1988;1(3):47–9.
  41. Carvalho CA, Silva MB, Oliveira TG, Lima JM, Rosa MB. Spectrometric study at different phenologic stages of the cabbage (Brassica oleracea capitata). Rev Bras Farmacogn. 2008;18:249–57.
  42. Silva Jr AA, Miura L, Yokoyama S. Repolho: Novas cultivares de verão. Agrop Catarinense. 1988;1(3):47–9.
  43. Das AK, Bigoniya P, Verma NK, Rana AC. Gastroprotective effect of Achyranthes aspera Leaf on rats. Asian Pac J Trop Med. 2012;5:197–201.
  44. Czekaj R, Majka J, Magierowska K, Sliwowski Z, Magierowski M, Pajdo R, et al. Mechanisms of coconut-induced gastroprotection against ethanol-induced gastric mucosal lesions. J Gastroenterol. 2018;53:618–30.
  45. Vimala G, Gricilda Shoba F. A review on antiulcer activity of few Indian medicinal plants. Int J Microbiol. 2014;2014:519590.
  46. Czekaj R, Majka J, Magierowska K, Sliwowski Z, Magierowski M, Pajdo R, et al. Mechanisms of coconut-induced gastroprotection against ethanol-induced gastric mucosal lesions. J Gastroenterol. 2018;53:618–30.
  47. Adnyana IK, Sigit JI, Kusumawardani LA. Gastric ulcer healing effect of wild honey and its combination with turmeric (Curcuma domestica) rhizome on male Wistar rats. J Chin Pharm Sci. 2014;23:844–9.
  48. Almasaudi SB, El-Shitany NA, Abbas AT, Abdel-Dayem UA, Ali SS, Al Jaouni SK, et al. Antioxidant, anti-inflammatory, and antiulcer potential of manuka honey against gastric ulcer in rats. Oxid Med Cell Longev. 2016;2016:3643824.
  49. Nadkarni KM. Indian Materia Medica. Mumbai: Popular Prakashan; 1976. Vol. 1. p. 65–71.
  50. Azamthulla M, Asad M, Prasad VS. Antiulcer activity of Allium sativum bulb juice in rats. Saudi Pharm J. 2009;17(1):70–7.
  51. Sarwar AKMG. Medicinal and aromatic plant genetic resources of Bangladesh and their conservation at the Botanical Garden, Bangladesh Agricultural University. Int J Minor Fruits Med Arom Plants. 2020;6(2):13–19.
  52. Mishra A, Arora S, Gupta R, Manvi PRK, Sharma AK. Effect of Feronia elephantum (Corr) fruit pulp extract on indomethacin-induced gastric ulcer in albino rats. Trop J Pharm Res. 2009;8:509–14.
  53. Singh S, Majumdar DK. Evaluation of the gastric antiulcer activity of fixed oil of Ocimum sanctum (Holy Basil). J Ethnopharmacol. 1999;65(1):13–19.
  54. Nadkarni KM. Indian Materia Medica. Mumbai: Popular Prakashan; 1976. Vol. 1. p. 552–3.
  55. Agarwal S, Sharma TR. Multiple biological activities of Aloe barbadensis (Aloe vera): An overview. Asian J Pharm Life Sci. 2011;1:195–205.
  56. Borra SK, Lagisetty RK, Mallela GR. Anti-ulcer effect of Aloe vera in non-steroidal anti-inflammatory drug induced peptic ulcers in rats. Afr J Pharm Pharmacol. 2011;5:1867–71.
  57. Kottaimuthu R. Ethnobotany of the Valaiyans of Karandamalai, Dindigul District, Tamil Nadu, India. Ethnobot Leafl. 2008;12:195–203.
  58. Indran M, Mahmood AA, Kuppusamy VR. Protective effect of Carica papaya leaf extract against alcohol-induced acute gastric damage and blood oxidative stress in rats. West Indian Med J. 2008;57(4):323–6.
  59. Szekalska M, Amelian A, Winnicka K. Alginate microspheres obtained by spray-drying technique as mucoadhesive carriers of ranitidine. Acta Pharm. 2015 Mar;65(1):67–75. doi:10.1515/acph- 2015-0008.
  60. Sallam AAM, Darwish SF, El-Dakroury WA, et al. Olmesartan noisome ameliorates the indomethacin-induced gastric ulcer in rats: Insight on MAPK and Nrf2/HO-1 signalling pathway. Pharm Res. 2021;38:1821–38. doi:10.1007/s11095-021-03212-5.
  61. Teaima MH, El Mohamady AM, El-Nabarawi MA, Mohamed AI. Formulation and evaluation of niosomal vesicles containing ondansetron HCL for trans-mucosal nasal drug delivery. Drug development and industrial pharmacy. 2020 May 3;46(5):751-61.
  62. Product brochures. Available from: http://www.indena.com/pages/brochures.php. Accessed April 21, 2011.
  63. Farinacci M, Gaspardo B, Colitti M, Stefanon B. Dietary administration of curcumin modifies transcriptional profile of genes involved in inflammatory cascade in horse leukocytes. Ital J Anim Sci. 2009;8:84–6.
  64. Nefful USA. Product-Information. Nefful’s anti-aging skin supplement – A natural skin regimen. Available from: http://www.neffulusa.com/downloads/pdf/2009/AR_Ingredient_Information.pdf. Accessed April 21, 2011.
  65. Bombardelli E, Bonati A, Gabetta B, Mustich G. Triterpenoids of Terminalia sericea. Phytochemistry. 1974;13:2559–62.
  66. Gastric antacid patents. Available from: https://patents.justia.com/search?q=Gastric+Antacid+Hydrotalcite
  67. Savoury E, Higginbottom M, Oliver K, Viet A. Proximagen Limited. US patent application. Nov 15, 2016.
  68. Joe B, Seldom. Puricore Inc. US patent application. Jan 21, 2014.
  69. Engstad R, Sejelid R. Biotech Pharmakon ASA. US patent application. Dec 16, 2014.
  70. Yelle WE, Handley DA. Sepracor Inc. US patent application. Sep 25, 2001.
  71. Katsuki K, Okada A. Kyowa Chemical Industry Co., Ltd. US patent application. Feb, 2013.
  72. Katsuki K, Okada A. Kyowa Chemical Industry Co., Ltd. US patent application. Jul 10, 2012.
Regular Issue Subscription Original Research
Volume 12
Issue 02
Received 09/04/2025
Accepted 12/05/2025
Published 02/08/2025
Publication Time 115 Days
157

Login


My IP

PlumX Metrics