Nanoparticle-Based Early Diagnostic Tools for Tuberculosis and Malaria in Rural India

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nThis is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.n

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Year : 2025 [if 2224 equals=””]02/10/2025 at 12:58 PM[/if 2224] | [if 1553 equals=””] Volume : 12 [else] Volume : 12[/if 1553] | [if 424 equals=”Regular Issue”]Issue : [/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] 02 | Page : 45 51

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    Stephen Monday, Atul Khajuria, Eric Kwasi Elliason, Gagan Singh, J. Samuel Kamanda1,

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  1. Research Fellow, Director, Research Fellow, Research Fellow, Research Fellow, Faculty of Allied Health Sciences, Desh Bhagat University, Mandi Gobindgarh, Faculty of Allied Health Sciences, Desh Bhagat University, Mandi Gobindgarh, Faculty of Allied Health Sciences, Desh Bhagat University, Mandi Gobindgarh, Faculty of Allied Health Sciences, Desh Bhagat University, Mandi Gobindgarh, Faculty of Allied Health Sciences, Desh Bhagat University, Mandi Gobindgarh, Punjab, Punjab, Punjab, Punjab, Punjab, India, India, India, India, India

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nMalaria and Tuberculosis continue to be two major public health challenges in rural India. The interplay between an inefficient health care system, late diagnosis, and under-identification of cases contributes to the high morbidity and mortality associated with TB and Malaria. Conventional methods, such as sputum microscopy for TB, microscopy and rapid diagnostic tests (RDTs) for malaria, have a higher benchmark of sensitivity that requires a certain amount of time, skilled personnel, and facilities. These methods also must be performed in labs. For lower resource settings, Nanoparticle based diagnostic technologies offer rapid, point-of-care sensitive diagnosis that can be adapted easily. Through research conducted in rural Bihar, Odisha, Chhattisgarh, Madhya Pradesh, and Jharkhand, this review assesses the public health impact, accessibility, efficiency, and utility of early detection tools for TB and malaria using nanoparticles among 3000056 participants by analyzing data from a field study. For ease of use, community acceptance, and turnaround time, gold nanoparticles (AuNPs), magnetic nanoparticles (MNPs), and quantum dots (QDs) outperformed other methods for sensitivity, specificity, and accuracy. The use of nanoparticles within the biosensor framework positively impacted the number of early TB and malaria detections, showing significant improvements. In comparison to conventional methods, acceptance from healthcare professionals alongside patients indicate the practicality of utilizing these innovations among unserved populations. Furthermore, both sensitivity and specificity reached outstanding levels of 94%, with an over 80% reduction in average diagnostic time. As showcased in this work, nanoparticle-based diagnostics could revolutionize disease detection at the site of care. These innovations will aid in the national efforts towards tuberculosis elimination and malaria control in underdeveloped regions.nn

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Keywords: Nanoparticles, tuberculosis, malaria, diagnostics, rural India, biosensors, public health, gold nanoparticles, quantum dots

n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Drug Design & Discovery ]

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nStephen Monday, Atul Khajuria, Eric Kwasi Elliason, Gagan Singh, J. Samuel Kamanda1. [if 2584 equals=”][226 wpautop=0 striphtml=1][else]Nanoparticle-Based Early Diagnostic Tools for Tuberculosis and Malaria in Rural India[/if 2584]. Research & Reviews: A Journal of Drug Design & Discovery. 25/06/2025; 12(02):45-51.

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nStephen Monday, Atul Khajuria, Eric Kwasi Elliason, Gagan Singh, J. Samuel Kamanda1. [if 2584 equals=”][226 striphtml=1][else]Nanoparticle-Based Early Diagnostic Tools for Tuberculosis and Malaria in Rural India[/if 2584]. Research & Reviews: A Journal of Drug Design & Discovery. 25/06/2025; 12(02):45-51. Available from: https://journals.stmjournals.com/rrjoddd/article=25/06/2025/view=0

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[if 424 not_equal=””]Regular Issue[else]Published[/if 424] Subscription Review Article

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Volume 12
[if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] 02
Received 17/04/2025
Accepted 21/04/2025
Published 25/06/2025
Retracted
Publication Time 69 Days

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