Oral Thin Films of Ondanetron Hcl: Formulation and Performance Evaluation

Year : 2024 | Volume : 11 | Issue : 03 | Page : 1 6
    By

    Chenna M Shalini,

  • Asireddy Sathvika Reddy,

  • Vallarapu Nanda Krishna Veni,

  • Madhira Jayaprakash,

  • Rama Rao T,

  1. Associate Professor, Department of Pharmaceutics, CMR College of Pharmacy, Hyderabad, Telangana, India
  2. Research Scholar, Department of Pharmacy, CMR College of Pharmacy, Hyderabad, Telangana, India
  3. Research Scholar, Department of Pharmacy, CMR College of Pharmacy, Hyderabad, Telangana, India
  4. Research Scholar, Department of Pharmacy, CMR College of Pharmacy, Hyderabad, Telangana, India
  5. Principal, CMR College of Pharmacy, Hyderabad, Telangana, India

Abstract

This study had the goal to formulate oral polymeric thin film that would dissolve and disintegrate instantly, while also having high mechanical features. These are the most advanced forms of solid dosage forms. Solvent casting was the technique employed to create oral thin films. These are additionally referred to as buccal films/strip, mouth dissolving films, oral thin films, as well as oral strips of paper. These films are suitable for both elderly and young individuals because they dissolve instantly and do not require water. Their quick dissolution facilitates rapid drug absorption through the oral mucosa, enhancing bioavailability and enabling swift onset of action, which is particularly vital for medications requiring immediate effects or emergency situations. Advantages of these films include convenient dosing, no risk of chocking, patient compliance, site specific and local action. Special features of these films include dose accuracy, mucoadhesive, rapid release. For the manufacturing of oral thin film, ondansetron hydrochloride, an antiemetic drug categorized into BCS class II, was employed. Ondansetron is used for the prevention of the symptoms of chemotherapy-induced nausea and vomiting. It is an antagonist belonging to the serotonin 5-HT3 receptor class. To optimize the polymers HPMC E15, polymer content, plasticizer (glycerol, propylene glycol), and sweetener (aspartame), the formulations from the preliminary trial were investigated. The thickness, folding durability, drug content, swelling index, surface pH, in vitro disintegration time, along with in vitro dissolution investigations of the resulting films were investigated. Propylene glycol-prepared oral thin films responded better than the ones developed with glycerol plasticizer with regard to solubility and the breakdown capabilities. In less than 30 seconds, the optimal film (F2) began to break down, releasing more (92.23). By subjecting the data to statistical analysis (ANOVA) the observed f value is 1.36 and p value is 0.252.

Keywords: Oral thin films, ondansetron, polymers, solvent casting method, drug delivery systems.

[This article belongs to Research & Reviews: A Journal of Drug Design & Discovery ]

How to cite this article:
Chenna M Shalini, Asireddy Sathvika Reddy, Vallarapu Nanda Krishna Veni, Madhira Jayaprakash, Rama Rao T. Oral Thin Films of Ondanetron Hcl: Formulation and Performance Evaluation. Research & Reviews: A Journal of Drug Design & Discovery. 2024; 11(03):1-6.
How to cite this URL:
Chenna M Shalini, Asireddy Sathvika Reddy, Vallarapu Nanda Krishna Veni, Madhira Jayaprakash, Rama Rao T. Oral Thin Films of Ondanetron Hcl: Formulation and Performance Evaluation. Research & Reviews: A Journal of Drug Design & Discovery. 2024; 11(03):1-6. Available from: https://journals.stmjournals.com/rrjoddd/article=2024/view=171649


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References

  1. Patel R, Shardul N, Patel J, Baria A. Formulation development and evaluation of mouth melting film of Ondansetron. Arch Pharm Sci Res. 2009;1(2):212–217.
  2. Venkateswarlu K. Preparation and evaluation of fast dissolving Buccal Thin Films of Bufotenin. J In Silico In Vitro Pharmacol. 2016;2(4):12.
  3. Amnuaikit C, Ikeuchi I, Ogawara KI, Higaki K, Kimura T. Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal use. Int J Pharm. 2005 Jan 31; 289(1–2):167–78.
  4. Vijayabhaskar K, Venkateswarlu K, Thirumalesh Naik SB, Kiran Jyothi R, Nethra Vani G, Chandrasekhar KB. Preparation and in-vitro evaluation of ranitidine mucoadhesive microspheres for prolonged gastric retention. Br J Pharm Res. 2016 Jan 1;10(2):1–2.
  5. Hobbs D, Karagianis J, Treuer T, Raskin J. An in vitro analysis of disintegration times of different formulations of olanzapine orodispersible tablet: a preliminary report. Drugs in R&D. 2013 Dec; 13:281–8.
  6. Jyothi SA, Mounika P, Vineesha S, Mehdia S, Dutt NA. Formulation development and evaluation of Oral Thin Films – Diphenhydramine HCl. Int J Pharm Sci Res. 2013;4(9):3484–3488. DOI: 10.13040/IJPSR.0975-8232.4(9).3484-88
  7. Saxena A. Formulation and evaluation of Oral Dissolving Films of Ondansetron HCl. World J Pharm Res. 2020;9(7):2019–2036.
  8. Nagendrakumar D, Keshavshetti GG, Mogale PR, Swami SW, Swami HA. Formulation and evaluation of fast dissolving oral films of metoprolol succinate. Int J Eng Appl Sci. 2015 Apr;6:28–37.
  9. Çoban Ö, Özcan K, Engin S, Tatar B, Soylu M. Formulation and evaluation of Triamcinolone Acetonide-loaded Oral Disintegrated Film with Different Polymers via Solvent Casting Method. Turk J Pharm Sci. 2023:1–15.
  10. Rashid A, Khan IU, Khalid SH, Asghar S, Munir MU. Development and evaluation of oral fast disintegrating film of ranitidine HCl by solvent casting method. Pak J Pharm Sci. 2021 Jul 2:34.
  11. Sri KV, Rohini P, Reddy GK. Montelukast sodium oral thin films: Formulation and invitro evaluation. Asian J Pharm Clin Res. 2012;5(4):266–70.
  12. Sandri G, Bonferoni MC, Ferrari F, Rossi S, Caramella C. Differentiating factors between oral fast-dissolving technologies. Am J Drug Delivery. 2006;4:249–262.
  13. Borsadia SB, O’Halloran D, Osborne JL. Quick-dissolving films: A novel approach to drug delivery. Drug Delivery Technol 2003 May;3(3):63.
  14. Lakshmi PK, Sreekanth J, Sridharan A. Formulation development of fast releasing oral thin films of levocetrizine dihydrochloride with Eudragit® Epo and optimization through Taguchi orthogonal experimental design. Asian J Pharm (AJP). 2011;5(2).
  15. Patel AR, Prajapati DS, Raval JA. Fast dissolving films (FDFs) as a newer venture in fast dissolving dosage forms. Int J Drug Dev Res. 2010 Apr;2(2):232–4.
  16. Rathbone M, Hadgraft J, Roberts MS, Lane ME. (Eds.). Modified-Release Drug Delivery Technol. 2013;1(2nd ed.). CRC Press. https://doi.org/10.3109/9781420044362.
  17. Semalty M, Semalty A, Kumar G. Formulation and characterization of mucoadhesive buccal films of glipizide. Indian Journal Pharm Sci. 2008 Jan;70(1):43–48.
  18. Bala R, Sharma S. Formulation optimization and evaluation of fast dissolving film of aprepitant by using design of experiment. Bull Faculty of Pharm, Cairo University. 2018 Dec 1;56(2):159–68.
  19. Basit AW, Lacey LF. Colonic metabolism of ranitidine: Implications for its delivery and absorption. Int J Pharm. 2001 Oct 4;227(1–2):157–65.
  20. Jayjock E, Schmitt R, Chein C, Tirol G. Determination of fast dissolve oral film dissolution rate via conductivity. Miland, MI: The Dow Chemical Company. 2005;48674:1–4.
Regular Issue Subscription Review Article
Volume 11
Issue 03
Received 30/07/2024
Accepted 28/08/2024
Published 10/09/2024
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