Synthesis, Characterization and Evaluation of Pyridine derivatives

Year : 2024 | Volume : 11 | Issue : 02 | Page : 35 48
    By

    Alka Tyagi,

  • Pravin Roman,

  • Renuka Doiphode,

  • Sanjivani Chaudhary,

  1. Associate Professor, Shri Pandit Baburao Chaughule College of Pharmacy, Thane, Maharashtra, India
  2. Associate Professor, Shri Pandit Baburao Chaughule College of Pharmacy, Thane, Maharashtra, India
  3. Associate Professor, Shri Pandit Baburao Chaughule College of Pharmacy, Thane, Maharashtra, India
  4. Associate Professor, Shri Pandit Baburao Chaughule College of Pharmacy, Thane, Maharashtra, India

Abstract

Schiff bases, a class of organic compounds, have garnered significant attention due to their diverse applications in various fields such as pharmaceuticals, materials science, and coordination chemistry. This study provides a comprehensive overview of the synthesis of Schiff bases amino pyridine derivatives and aromatic ketones along with their anti-microbial activity. Method: The synthesis of Schiff bases primarily involves the condensation reaction between a primary amine and a carbonyl compound (ketone) along with glacial acetic acid. Various methods have been developed for the synthesis of Schiff bases. Classical methods typically involve refluxing the amine and carbonyl compound in a suitable solvent with or without a catalyst. In this research, nine new compounds of Schiff bases have been synthesized along with characterization and antibacterial and anti-fungal activities. Result: It was discovered that all elemental analyses, IR, 1H NMR, and mass spectrometry values were significant. According to antimicrobial and antifungal screening results, compounds PS-1 and compound PS-9 were found to be more active against all tested strains, while Schiff bases demonstrate substantial activity against Staphylococcus aureus and Candida albicans. PS-1 compound was found to have most activity in anti-bacterial test while PS-9 was found to possess best anti-fungal activity. Conclusion: The current study examines the pharmacological properties of pyridine derivatives. Pyridine derivative PS-1 was found to be most active antibacterial agent and PS-9 most active antifungal agent. The results of the study have important implications for future investigations into possible therapies for bacterial infections.

Keywords: Schiff base, Synthesis, Pharmacological evaluation, NMR spectroscopy, Pyridine derivatives.

[This article belongs to Research & Reviews: A Journal of Drug Design & Discovery ]

How to cite this article:
Alka Tyagi, Pravin Roman, Renuka Doiphode, Sanjivani Chaudhary. Synthesis, Characterization and Evaluation of Pyridine derivatives. Research & Reviews: A Journal of Drug Design & Discovery. 2024; 11(02):35-48.
How to cite this URL:
Alka Tyagi, Pravin Roman, Renuka Doiphode, Sanjivani Chaudhary. Synthesis, Characterization and Evaluation of Pyridine derivatives. Research & Reviews: A Journal of Drug Design & Discovery. 2024; 11(02):35-48. Available from: https://journals.stmjournals.com/rrjoddd/article=2024/view=165954


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Regular Issue Subscription Original Research
Volume 11
Issue 02
Received 04/07/2024
Accepted 26/07/2024
Published 12/08/2024
413

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