Fast Dissolving Oral Thin Films: A Review

Year : 2024 | Volume :11 | Issue : 01 | Page : –
By

Chenna M Shalini

Asireddy Sathvika Reddy

Vallarapu Nanda Krishna Veni

Madhira Jayaprakash

Rama Rao T

  1. Associate Professor CMR College of Pharmacy Telangana India
  2. Research Scholar CMR College of Pharmacy Telangana India
  3. Research Scholar CMR College of Pharmacy Telangana India
  4. Research Scholar CMR College of Pharmacy Telangana India
  5. Principal CMR College of Pharmacy Telangana India

Abstract

Fast-dissolving oral thin films (FDOFs) represent a significant advancement in drug delivery technology, offering advantages over traditional solid dosage forms, especially for patients with swallowing difficulties. FDOFs dissolve rapidly in the mouth, releasing the active ingredient without the need for water or chewing. They have picked up ubiquity due to their comfort, taste veiling capabilities, and progressed persistent compliance. Ideal drugs for FDOFs should possess characteristics such as solubility, stability, and compatibility with oral mucosal tissue. Various drug categories, including anti-emetics, serotonin inhibitors, anti-epileptics, anti-migraines, and statins, can be formulated as FDOFs. Formulating FDOFs involves considerations like selecting appropriate polymers, plasticizers, flavouring agents, and colorants. Methods of preparation include solvent casting, semi-solid casting, hot-melt extrusion, solid dispersion, and rolling methods. Evaluation methods ensure quality control, covering aspects like weight uniformity, thickness, dryness, surface pH, tensile strength, disintegration time, and in-vitro drug release studies. Recent developments in FDOFs extend their applications to pain relief, CNS diseases, wound care, and controlled release of sensitive reagents. Despite their advantages, challenges remain in formulation, manufacturing, and market competition. In conclusion, FDOFs offer a promising drug delivery platform with broad applications and benefits, although further research and optimization are necessary to address existing challenges and realize their full potential in modern pharmaceuticals.

Keywords: Fast dissolving films, Polymers, Solvent casting method, Fast Dissolving Tablets, Orally disintegrating films.

[This article belongs to Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)]

How to cite this article: Chenna M Shalini, Asireddy Sathvika Reddy, Vallarapu Nanda Krishna Veni, Madhira Jayaprakash, Rama Rao T. Fast Dissolving Oral Thin Films: A Review. Research & Reviews: A Journal of Drug Design & Discovery. 2024; 11(01):-.
How to cite this URL: Chenna M Shalini, Asireddy Sathvika Reddy, Vallarapu Nanda Krishna Veni, Madhira Jayaprakash, Rama Rao T. Fast Dissolving Oral Thin Films: A Review. Research & Reviews: A Journal of Drug Design & Discovery. 2024; 11(01):-. Available from: https://journals.stmjournals.com/rrjoddd/article=2024/view=143301


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Vol 8 Issue 06, 20


Regular Issue Subscription Review Article
Volume 11
Issue 01
Received March 19, 2024
Accepted April 4, 2024
Published April 15, 2024