Panner Selvam R
- Associate Professor, Department of Pharmaceutics, T. John College of Pharmacy, Bengaluru, Karnataka, India
- Professor, Department of Pharmaceutics, T. John College of Pharmacy, Bengaluru, Karnataka, India
- Lecturer, Department of Pharmaceutical Chemistry, T. John College of Pharmacy, Bengaluru, Karnataka, India
- Professor, r, Department of Pharmaceutical Chemistry, T. John College of Pharmacy, Bengaluru, Karnataka, India
The most difficult feature of many novel chemical entities is their solubility behaviour, as 60 percent of new promising products suffer solubility limitations. This is the most common reason for novel medicine compounds failing to reach the market or performing to their full potential. The proportion of the aqueous phase when the solution is in equilibrium with the pure substance in its normal phase is referred to as aqueous solubility. The greatest dose strength of an immediate release medication is used to determine solubility. Physical and chemical alteration of the medication, as well as other strategies, has all been used to boost the solubility of poorly soluble drugs. The pharmacological qualities, absorption site, and desired dosage form characteristics all influence which solubility augmentation strategy is used. This review article examines various novel ways to improving the solubility of weakly water-soluble compounds.
Keywords: Solubility, poorly soluble, strategies, absorption
[This article belongs to Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)]
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|Received||August 27, 2021|
|Accepted||October 27, 2021|
|Published||November 10, 2021|