Nicky Kumar Jaiswal,
Mushahid ul Rehman,
Tahir Ahmed,
- Assistant Professor, Department of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab, India
- Student, Department of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab, India
- Student, Department of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab, India
Abstract
Betel quid without tobacco, a popular cultural product across India and other South and Southeast Asian nations, is often consumed for its refreshing stimulant effects during social and religious gatherings. Despite its deep cultural significance, the health hazards of betel quid – especially its strong association with oral cancers – are often overlooked. The International Agency for Research on Cancer (IARC) has identified betel quid as a human carcinogen, and research from countries, such as India, Pakistan, and Taiwan, highlights a troubling link between its use and the increasing rates of oral cancer. India, with one of the highest oral cancer rates globally, faces significant public health challenges due to the widespread use of betel quid, especially in its tobacco-free form. The primary ingredient, areca nut, contains alkaloids and polyphenols that contribute to oxidative stress, inflammation, and DNA damage – critical factors in cancer development. Additionally, including lime further exacerbates these harmful effects by increasing the alkalinity of the mouth, promoting carcinogenesis. While tobacco is often mixed with betel quid in India and Pakistan, complicating the ability to assess the independent risks of areca nut and lime, Taiwan’s high prevalence of tobacco-free betel quid consumption provides clearer evidence of its potential dangers. This literature review critically examines both global and Indian perspectives on the health risks of betel quid use, shedding light on the emerging evidence linking it to cancer. Despite growing scientific awareness, the carcinogenic effects of non-tobacco betel quid remain largely neglected in public health campaigns. To reduce the burden of oral cancer, this review calls for increased awareness, more stringent regulations, and culturally sensitive interventions, particularly targeting vulnerable youth. Addressing the risks of betel quid consumption is essential for lowering oral cancer rates and improving public health outcomes across South and Southeast Asia.
Keywords: Betel quid, Areca nut, Oral cancer, Tobacco-free betel quid, Carcinogenesis
[This article belongs to Research and Reviews: A Journal of Dentistry ]
Nicky Kumar Jaiswal, Mushahid ul Rehman, Tahir Ahmed. Betel Quid without Tobacco: A Threat to Oral Health and Well-being in India. Research and Reviews: A Journal of Dentistry. 2025; 16(03):6-16.
Nicky Kumar Jaiswal, Mushahid ul Rehman, Tahir Ahmed. Betel Quid without Tobacco: A Threat to Oral Health and Well-being in India. Research and Reviews: A Journal of Dentistry. 2025; 16(03):6-16. Available from: https://journals.stmjournals.com/rrjod/article=2025/view=228185
References
- Thomas, S., & Kearsley, J. (1993). Betel quid and oral cancer: a review. European Journal of Cancer Part B: Oral Oncology, 29(4), 251-255. https://doi.org/10.1016/0964-1955(93)90044-F
- Jacob, B. J., Straif, K., Thomas, G., Ramadas, K., Mathew, B., Zhang, Z.‐F., Sankaranarayanan, R., & Hashibe, M. (2004). Betel quid without tobacco as a risk factor for oral precancers. Oral Oncology, 40(7), 697-704. https://doi.org/10.1016/j.oraloncology.2004.01.005
- Gupta, B., & Johnson, N. W. (2014). Systematic review and meta-analysis of the association of smokeless tobacco and betel quid without tobacco with the incidence of oral cancer in South Asia and the Pacific. PloS One, 9(11), e113385. https://doi.org/10.1371/journal.pone.0113385
- Amarasinghe, H. K., Usgodaarachchi, U. S., Johnson, N. W., Lalloo, R., & Warnakulasuriya, S. (2010). Betel-quid chewing with or without tobacco is a major risk factor for oral potentially malignant disorders in Sri Lanka: a case-control study. Oral Oncology, 46(4), 297-301. https://doi.org/10.1016/j.oraloncology.2010.01.017
- Thennakoon, T. A. K. (2024). A Case-Control Study to Assess The Relationship between Betel Quid Chewing and Oral Cancer Incidence Among Adult Male And Female Populations in Sri Lanka.
- Ko, A. M.-S., Wu, P.-W., Lin, W.-T., & Lee, C.-H. (2024). Betel-quid addictive use disorders and Oral potentially malignant disorders and Oral cancer in South, southeast, and East Asia: A systematic review and meta-analysis. Oral Diseases. https://doi.org/10.1111/odi.15106
- Lin, C.-F., Wang, J.-D., Chen, P.-H., Chang, S.-J., Yang, Y.-H., & Ko, Y.-C. (2006). Predictors of betel quid chewing behavior and cessation patterns in Taiwan aborigines. BMC Public Health, 6, 271. https://doi.org/10.1186/1471-2458-6-271
- Gunjal, S., Pateel, D. G. S., Yang, Y.-H., Doss, J. G., Bilal, S., Maling, T. H., Mehrotra, R., Cheong, S. C., & Mohd Zain, R. B. (2020). An overview on betel quid and areca nut practice and control in selected Asian and South East Asian countries. Substance Use & Misuse, 55(9), 1533-1544. https://doi.org/10.1080/10826084.2019.1657149
- Ahuja, S. C., & Ahuja, U. (2011). Betel leaf and betel nut in India: History and uses. Asian Agrihist, 15(1), 13-35.
- Khan, Z. (2016). Oral cancer via the bargain bin: the role of smokeless tobacco in the etiology of oral cancer. PhD dissertation, Universität Bremen.
- Garg, A., Chaturvedi, P., & Gupta, P. C. (2014). A review of the systemic adverse effects of areca nut or betel nut. Indian Journal of Medical and Paediatric Oncology, 35(1), 3-9.
- Sari, L. M. (2021). Antioxidant activity of areca nut to human health: Effect on oral cancer cell lines and immunomodulatory activity. In Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health (pp. 1-10). IntechOpen.
- Nair, U., Bartsch, H., & Nair, J. (2004). Alert for an epidemic of oral cancer due to use of the betel quid substitutes gutkha and pan masala: A review of agents and causative mechanisms. Mutagenesis, 19(4), 251-262. https://doi.org/10.1093/mutage/geh036
- Javed, F., Chotai, M., Mehmood, A., & Almas, K. (2010). Oral mucosal disorders associated with habitual gutka usage: A review. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 109(6), 857-864. https://doi.org/10.1016/j.tripleo.2009.12.038
- Sharan, R. N., Mehrotra, R., Choudhury, Y., & Asotra, K. (2012). Association of betel nut with carcinogenesis: Revisit with a clinical perspective. e42759.
- Sharma, M., Shetty, S. S., & Radhakrishnan, R. A. (2022). Novel pathways and mechanisms of nicotine-induced oral carcinogenesis. Recent Patents on Anti-Cancer Drug Discovery, 17(1), 66-79. https://doi.org/10.2174/1574892816666210806161312
- Mehrotra, D., Kumar, S., Mishra, S., Kumar, S., Mathur, P., Pandey, C. M., Pandey, A., & Chaudhry, K. (2017). Pan masala habits and risk of oral precancer: A cross-sectional survey in 0.45 million people of North India. Journal of Oral Biology and Craniofacial Research, 7(1), 13-18.
- Zhang, C., Li, B., Zeng, X., Hu, X., & Hua, H. (2023). The global prevalence of oral leukoplakia: A systematic review and meta-analysis from 1996 to 2022. BMC Oral Health, 23(1), 645.
- Singhal, J., Verma, S., Kumar, S., & Mehrotra, D. (2021). Recent advances in nano-bio-sensing fabrication technology for the detection of oral cancer. Molecular Biotechnology, 63(5), 339-362.
- Sandhya, G. I., Sunil, S., & Abraham, B. (2013). Prevalence of pan masala use in a coastal population of Kerala. Education, 139, 13.
- Aruna, D. S., Prasad, K. V., Shavi, G. R., Ariga, J., Rajesh, G., & Krishna, M. (2011). Retrospective study on risk habits among oral cancer patients in Karnataka Cancer Therapy and Research Institute, Hubli, India. Asia Pacific Journal of Cancer Prevention, 12(6), 1561-1566.
- Gupta, P. C., & Ray, C. S. (2003). Smokeless tobacco and health in India and South Asia. Respirology, 8(4), 419-431.
- Goldenberg, D., Lee, J., Koch, W. M., et al. (2004). Habitual risk factors for head and neck cancer. Otolaryngology-Head and Neck Surgery, 131(6), 986-993.
- Kumar, S. (2008). Pan masala chewing induces deterioration in oral health and its implications in carcinogenesis. Toxicological Mechanisms and Methods, 18(9), 665-677.
- Priebe, S. L., Aleksejūnienė, J., Zed, C., et al. (2010). Oral squamous cell carcinoma and cultural oral risk habits in Vietnam. International Journal of Dental Hygiene, 8(3), 159-168.
- Huang, T.-T., Huang, J.-S., Wang, Y.-Y., Chen, K.-C., Wong, T.-Y., Chen, Y.-C., Wu, C.-W., et al. (2017). Novel quantitative analysis of autofluorescence images for oral cancer screening. Oral Oncology, 68, 20-26.
- Ikeda, N., Handa, Y., Khim, S. P., et al. (1995). Prevalence study of oral mucosal lesions in a selected Cambodian population. Community Dentistry and Oral Epidemiology, 23(1), 49-54.
- Ganaraja, K. “A Comparative Anaysis of Trends in Area, Production and Productivity of Areca Nut.” International Journal of Social and Economic Research7, no. 1 (2017): 50-60.
- Ashoka, N., N. Shashidhara, Y. Ravi, S. Vishwanatha, and R. Raju. “Arecanut (Areca catechu L.) plantation for enhancing farmer’s income: An evidence from Karnataka state.” Indian Journal of Extension Education57, no. 4 (2021): 9-16.
- Suryanarayana, M. A., K. T. Vasantha, B. K. Hima, and A. N. Lokesha. “Status of Betelvine cultivation in Karnataka.” In Conference paper. Section of Medicinal Crops, Indian Institute of Horticultural Research, Bangalore. 2014.
- Thakur, Nisha, and Ravi Mehrotra. “Carcinogenic Alkaloids Present in Areca Nut: How Do They Compare to Tobacco.” In Handbook of Substance Misuse and Addictions: From Biology to Public Health, pp. 1-21. Cham: Springer International Publishing, 2022. DOI https://doi.org/10.1007/978-3-030-67928-6_84-1
- Jeng, J. H., M. C. Chang, and L. J. Hahn. “Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives.” Oral oncology37, no. 6 (2001): 477-492. https://doi.org/10.1016/S1368-8375(01)00003-3
- Myers, Alan L. “Metabolism of the areca alkaloids–toxic and psychoactive constituents of the areca (betel) nut.” Drug Metabolism Reviews54, no. 4 (2022): 343-360.
- Nethan, Suzanne Tanya, Shalini Gupta, and Saman Warnakulasuriya. “Risk factors for oral squamous cell carcinoma in the Indian population.” In Microbes and Oral Squamous Cell Carcinoma: A Network Spanning Infection and Inflammation, pp. 9-40. Singapore: Springer Nature Singapore, 2022.
- Trivedy, C. R., G. Craig, and S. Warnakulasuriya. “The oral health consequences of chewing areca nut.” Addiction biology7, no. 1 (2002): 115-125.
- Chen, Ping-Ho, Qaisar Mahmood, Gian Luigi Mariottini, Tai-An Chiang, and Ka-Wo Lee. “Adverse health effects of betel quid and the risk of oral and pharyngeal cancers.” BioMed research international2017, no. 1 (2017): 3904098.
- Warnakulasuriya, Saman, and T. H. H. Chen. “Areca nut and oral cancer: evidence from studies conducted in humans.” Journal of dental research101, no. 10 (2022): 1139-1146. https://doi.org/10.1177/00220345221092751
- Goodman, J. (2005). Tobacco in History: The Cultures of Dependence. Routledge.
- Gupta, Prakash C., and Cecily S. Ray. “Areca nut use and cancer in India.” Biomedical Research Journal2, no. 2 (2015): 140-165.
- Ali, I., Wani, W. A., & Saleem, K. (2011). Cancer scenario in India with future perspectives. Can Ther, 8(1), 56-70.

Research and Reviews: A Journal of Dentistry
| Volume | 16 |
| Issue | 03 |
| Received | 13/05/2025 |
| Accepted | 08/06/2025 |
| Published | 27/09/2025 |
| Publication Time | 137 Days |
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