In Situ Investigation of Hemidesmus indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukemia

Year : 2024 | Volume : 13 | Issue : 01 | Page : 38 53
    By

    Roshithaa Pillai,

  1. Research Intern, Department of Bioinformatics, BioNome, Karnataka, India

Abstract

 Objective: Acute myeloid leukemia (AML) is an apoptotic condition in the hematopoietic system induced by the differentiation and maturation of stem cells into erythrocytes, and leukemic cell proliferation is suppressed as the PI3K-Akt-mTOR pathway is pharmacologically targeted with certain inhibitors. As a result, in silico molecular docking of compounds against AML receptors, CTMP, was used in computational research on Hemidesmus indicus to uncover therapeutic phytochemicals for AML. Thus, this study concludes that the identification of natural product-based therapeutic candidates can be facilitated by a combination of empirical information, in silico molecular docking, and ADME profiling. Methods: An in silico examination was performed to treat acute myeloid leukemia. In this study, the phytoconstituents of Hemidesmus indicus were thoroughly reviewed based on its cylindrical root as a natural remedy for ailments. The pharmacology of the selected compounds was screened for ADME drug-likeness. Ultimately, the screening process was finalized by employing PyRx and Biovia to dock the chosen compound with a leukemia-targeted suppressor protein. Results: Current in silico study on AML, Quercetin, the most abundant flavonoids with multiple properties capable of reducing cell growth in cancer cells with acute myeloid leukemic condition. Conclusion: Overall, the notable insights in pharmacological research studies on AML at the level of its immature stem cells and a better understanding of the molecular mechanism of the disorder would be beneficial to recommend H. indicus root as a therapeutic target. AML-related proteins were retrieved from the PDB database for molecular docking results in the discovery of a new drug and medicinal therapeutic agent for the most effective root-based H. indicus. The CTMP protein acts as an anti-leukemic suppressor protein, which develops effective protein-ligand complexes.

Keywords: Hemidesmus Indicus, Acute myeloid leukaemia, phytocompounds, pharmacology, apoptosis, therapeutic targets.

[This article belongs to Research & Reviews : Journal of Computational Biology ]

How to cite this article:
Roshithaa Pillai. In Situ Investigation of Hemidesmus indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukemia. Research & Reviews : Journal of Computational Biology. 2024; 13(01):38-53.
How to cite this URL:
Roshithaa Pillai. In Situ Investigation of Hemidesmus indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukemia. Research & Reviews : Journal of Computational Biology. 2024; 13(01):38-53. Available from: https://journals.stmjournals.com/rrjocb/article=2024/view=151230


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Regular Issue Subscription Original Research
Volume 13
Issue 01
Received 27/03/2024
Accepted 03/04/2024
Published 13/04/2024
396

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