Haemoglobin-The Breath of Life within Our Cells: An Update

Year : 2024 | Volume :14 | Issue : 01 | Page : 25-31
By

    Ajit Pal Singh

  1. Aakriti Acharya

  1. Assistant Professor, Department of Medical Lab Technology, Sharda University, Gr. Noida, Uttar Pradesh, India
  2. Student, Department of Medical Lab Technology, Sharda University, Gr. Noida, Uttar Pradesh, India

Abstract

Haemoglobin is a fascinating protein found in human red blood cells. This specialist protein carries oxygen from your lungs to every cell in your body, functioning as a little delivery system. While haemoglobin’s strong hold on oxygen is necessary, releasing it at the right time is a delicate challenge. This adaptable protein masterfully balances holding on to its oxygen cargo or releasing it swiftly. This article explores how haemoglobin achieves this remarkable feat. The key lies in the changing conditions within your body! During exercise, your body creates a kind of “acid rain” that signals the need for oxygen, prompting haemoglobin to release its precious cargo. Similarly, the thinner air of high altitudes, such as the Alps, encourages haemoglobin to cling to oxygen molecules, ensuring adequate oxygen supply. This mesmerizing interplay between oxygen, haemoglobin, and your body’s ever-changing needs fuels your energy to run, play, and explore. Haemoglobin is an iron-rich protein found in red blood cells. It plays a crucial role in transporting oxygen throughout the body, making it essential for life. The various processes governing haemoglobin’s affinity for binding oxygen are examined in this abstract, along with its physiological significance. Two molecules that bind to oxygen reversibly are found in each of the four globin chains that make up haemoglobin. Oxygen binding to haemoglobin causes structural alterations in the surrounding globin chains, which alters haemoglobin’s oxygen affinity. The S-shaped oxygen dissociation curve reveals how factors like carbon dioxide, pH, and 2,3-diphosphoglycerate (2,3-DPG) influence the cooperative binding of oxygen to haemoglobin. The erythrocyte can buffer hydrogen ions and combine carbon dioxide with carbamino compounds thanks to haemoglobin, which also carries carbon dioxide in the blood. Atypical haemoglobins may result from alterations to the iron atom, globin chains, or the attachment of non-oxygen ligands.

Keywords: Oxygen, blood, binding, body, protein, erythrocyte

[This article belongs to Research & Reviews : A Journal of Biotechnology(rrjobt)]

How to cite this article: Ajit Pal Singh, Aakriti Acharya , Haemoglobin-The Breath of Life within Our Cells: An Update rrjobt 2024; 14:25-31
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Regular Issue Subscription Review Article
Volume 14
Issue 01
Received March 2, 2024
Accepted March 18, 2024
Published March 30, 2024
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