This is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.
Swati Dixit,
Mahi Singh Chauhan,
Padmini Mishra,
Archana Dwivedi,
- Student, Department of Computer Science & Engineering, Babu Banarasi Das Institute of Technology & Management, Lucknow, Uttar Pradesh, India
- Student, Student, Department of Computer Science & Engineering, Babu Banarasi Das Institute of Technology & Management, Lucknow, Uttar Pradesh, India
- Assistant Professor, Department of Computer Science & Engineering, Babu Banarasi Das Institute of Technology & Management, Lucknow, Uttar Pradesh, India
- Assistant Professor, Department of Computer Science & Engineering, Babu Banarasi Das Institute of Technology & Management, Lucknow, Uttar Pradesh, India
Abstract
The worldwide burden of Diabetes Mellitus, especially Type 2 diabetes (T2D) has escalated to a critical level. Early detection of diabetes is essential to reduce long‑term complications and healthcare costs. This study explores the use of artificial intelligence (AI) techniques to improve the early diagnosis and prevention of diabetes. We developed an AI model using the Random Forest algorithm, the model predicts diabetes risk based on clinical and lifestyle variables and identifies high‑risk individuals for targeted preventive interventions. We investigate the contribution of Explainable AI (XAI) techniques, including SHAP and LIME, to enhance clinician interpretability and trust. Performance was evaluated with metrics such as accuracy, sensitivity, and AUC, and compared to conventional risk‑scoring approaches. The proposed system improved predictive performance over traditional methods. These findings suggest that AI‑driven tools can support clinicians in early risk stratification and may facilitate personalised prevention strategies for diabetes in diverse populations.
Keywords: Diabetes Mellitus, Type 2 Diabetes (T2D), Early Diagnosis, Artificial Intelligence, Machine Learning, Random Forest, Explainable AI, SHAP, LIME, Predictive Analytics, Lifestyle Risk Factors, Personalized Prevention.
[This article belongs to Research & Reviews: A Journal of Bioinformatics ]
Swati Dixit, Mahi Singh Chauhan, Padmini Mishra, Archana Dwivedi. AI – Based Early Diagnosis & Prevention of Diabetes. Research & Reviews: A Journal of Bioinformatics. 2026; 13(02):-.
Swati Dixit, Mahi Singh Chauhan, Padmini Mishra, Archana Dwivedi. AI – Based Early Diagnosis & Prevention of Diabetes. Research & Reviews: A Journal of Bioinformatics. 2026; 13(02):-. Available from: https://journals.stmjournals.com/rrjobi/article=2026/view=242800
References
- Kavakiotis I, Tsave O, Salifoglou A, Maglaveras N, Vlahavas I, Chouvarda I. Machine learning and data mining methods in diabetes research. Comput Struct Biotechnol J. 2017;15:104–116. doi:10.1016/j.csbj.2016.12.005
- Zou Q, Qu K, Luo Y, Yin D, Ju Y, Tang H. Predicting diabetes mellitus with machine learning techniques. Front Genet. 2018;9:515. doi:10.3389/fgene.2018.00515
- Ahmad N, Khan S, Alghamdi NS, Alfakeeh AS, Alharbi M, Aljuaid H, et al. Diabetes prediction using ensemble machine learning techniques. IEEE Access. 2021;9:12345–12359. doi:10.1109/ACCESS.2021.3052303
- Chen JH, Asch SM. Machine learning and prediction in medicine—beyond the peak of inflated expectations. N Engl J Med. 2017;376(26):2507–2509. doi:10.1056/NEJMp1702071
- Rajkomar A, Dean J, Kohane I. Machine learning in medicine. N Engl J Med. 2019;380(14):1347–1358. doi:10.1056/NEJMra1814259
- Topol EJ. High-performance medicine: the convergence of human and artificial intelligence. Nat Med. 2019;25(1):44–56. doi:10.1038/s41591-018-0300-7
- Deo RC. Machine learning in medicine. Circulation. 2015;132(20):1920–1930. doi:10.1161/CIRCULATIONAHA.115.001593
- Choi E, Bahadori MT, Schuetz A, Stewart WF, Sun J. Doctor AI: predicting clinical events via recurrent neural networks. Proc Mach Learn Healthc Conf. 2016;56:301–318. doi:10.18653/v1/W16-4203
- Beam AL, Kohane IS. Big data and machine learning in health care. JAMA. 2018;319(13):1317–1318. doi:10.1001/jama.2017.18391
- Miotto R, Wang F, Wang S, Jiang X, Dudley JT. Deep learning for healthcare: review, opportunities and challenges. Brief Bioinform. 2018;19(6):1236–1246. doi:10.1093/bib/bbx044
- Dua D, Graff C. UCI machine learning repository [Internet]. Irvine (CA): University of California; 2019 [cited 2026 Apr 27]. Available from: https://archive.ics.uci.edu
- Smith A, Anderson M. Wearable technology use in health monitoring. NPJ Digit Med. 2020;3:45. doi:10.1038/s41746-020-0258-6
- Bini SA. Artificial intelligence, machine learning, deep learning, and cognitive computing: what do these terms mean and how will they impact health care? J Arthroplasty. 2018;33(8):2358–2361. doi:10.1016/j.arth.2018.02.067
- Lundberg SM, Lee SI. A unified approach to interpreting model predictions. Adv Neural Inf Process Syst. 2017;30:4765–4774. doi:10.48550/arXiv.1705.07874
- Breiman L. Random forests. Mach Learn. 2001;45(1):5–32. doi:10.1023/A:1010933404324
- Chen T, Guestrin C. XGBoost: a scalable tree boosting system. Proc ACM SIGKDD Int Conf Knowl Discov Data Min. 2016:785–794. doi:10.1145/2939672.2939785
- Cortes C, Vapnik V. Support-vector networks. Mach Learn. 1995;20:273–297. doi:10.1007/BF00994018
- Pedregosa F, Varoquaux G, Gramfort A, Michel V, Thirion B, Grisel O, et al. Scikit-learn: machine learning in Python. J Mach Learn Res. 2011;12:2825–2830.
- Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM, et al. Dermatologist-level classification of skin cancer with deep neural networks. Nature. 2017;542(7639):115–118. doi:10.1038/nature21056
- World Health Organization. Global report on diabetes [Internet]. Geneva: WHO; 2016 [cited 2026 Apr 27]. Available from: https://www.who.int/publications/i/item/9789241565257
- Zhu T, Li K, Herrero P, Georgiou P. IoT-based glucose monitoring systems: a review of recent trends. Sensors (Basel). 2020;20(3):891. doi:10.3390/s20030891
- Hossain MS, Muhammad G. Cloud-assisted industrial internet of things (IIoT)–enabled framework for health monitoring. Comput Sci Eng. 2020;22(1):45–54. doi:10.1109/MCSE.2019.2923901
- Clifton L, Clifton DA, Pimentel MA, Watkinson PJ, Tarassenko L. Predictive monitoring of mobile patients by combining clinical observations with data from wearable sensors. IEEE J Biomed Health Inform. 2014;18(3):722–730. doi:10.1109/JBHI.2013.2282052
- Goodfellow I, Bengio Y, Courville A. Deep learning. Cambridge (MA): MIT Press; 2016.
- IDF Diabetes Atlas 9th edition. Brussels: International Diabetes Federation; 2019.
- Breiman L. Random forests. Mach Learn. 2001;45(1):5–32. doi:10.1023/A:1010933404324
- Pedregosa F, Varoquaux G, Gramfort A, Michel V, Thirion B, Grisel O, et al. Scikit-learn: machine learning in Python. J Mach Learn Res. 2011;12:2825–2830.
- World Health Organization. Global report on diabetes. Geneva: WHO; 2016. Available from: https://www.who.int/publications/i/item/9789241565257
- Chollet F. Deep learning with Python. 2nd ed. Shelter Island (NY): Manning Publications; 2021.
- Harris CR, Millman KJ, van der Walt SJ, Gommers R, Virtanen P, Cournapeau D, et al. Array programming with NumPy. Nature. 2020;585(7825):357–362. doi:10.1038/s41586-020-2649-2
- McKinney W. Data structures for statistical computing in Python. In: Proc 9th Python Sci Conf; 2010. p. 51–56. doi:10.25080/Majora-92bf1922-00a
- Han J, Kamber M, Pei J. Data mining: concepts and techniques. 3rd ed. Burlington (MA): Morgan Kaufmann; 2011.
- He H, Garcia EA. Learning from imbalanced data. IEEE Trans Knowl Data Eng. 2009;21(9):1263–1284. doi:10.1109/TKDE.2008.239
- Kuhn M, Johnson K. Applied predictive modeling. New York: Springer; 2013.
- Altman NS. An introduction to kernel and nearest-neighbor nonparametric regression. Am Stat. 1992;46(3):175–185. doi:10.1080/00031305.1992.10475879
- Cortes C, Vapnik V. Support-vector networks. Mach Learn. 1995;20:273–297. doi:10.1007/BF00994018
- Hosmer DW, Lemeshow S, Sturdivant RX. Applied logistic regression. 3rd ed. Hoboken (NJ): John Wiley & Sons; 2013.
- Friedman JH. Greedy function approximation: a gradient boosting machine. Ann Stat. 2001;29(5):1189–1232. doi:10.1214/aos/1013203451
- Quinlan JR. Induction of decision trees. Mach Learn. 1986;1:81–106. doi:10.1007/BF00116251
- Rumelhart DE, Hinton GE, Williams RJ. Learning representations by back-propagating errors. Nature. 1986;323(6088):533–536. doi:10.1038/323533a0

Research & Reviews: A Journal of Bioinformatics
| Volume | 13 |
| Issue | 02 |
| Received | 13/04/2026 |
| Accepted | 24/04/2026 |
| Published | 04/05/2026 |
| Publication Time | 21 Days |
Login
PlumX Metrics