[{“box”:0,”content”:”[if 992 equals=”Open Access”]
Open Access
n
[/if 992]n
n
n
n
n
- n t
n
gouthami polaki, Nansri Saha
[/foreach]
n
n
n[if 2099 not_equal=”Yes”]n
- [foreach 286] [if 1175 not_equal=””]n t
- , , ,
n[/if 1175][/foreach]
[/if 2099][if 2099 equals=”Yes”][/if 2099]nn
Abstract
nOil entrapped floating calcium alginate beads of Telmisartan were successfully prepared using sodium
alginate as polymer and two different oil phases of mineral oil and olive oil by emulsion gelation method.
The FT-IR spectra of final optimized formulation confirms no drug- polymer incompatibility. The
floating time of beads was found to be more than 12 hrs suggesting that the method used for prepration
was effective. The floating time of optimized formulation was within 6 minutes and floating time
significantly increased as the amount of oil was increased in each formulation. The mean particle size
of beads was in range from (1.204 mm to 2.0072 mm) depending upon the type of polymer used. The
particle size increased significantly as the amount of polymer was increased in each preparation.
The %Entrapment efficiency of beads ranging from41.14%–85.79% increased in concentration of
polymer leads to increase in entrapment efficiency. The best formulation of oil entrapped floating
calcium alginate beads of Telmisartan for mineral oil was found to be F5 98.03% and for Olive oil oil
was found to be F7 96.7%, drug release in 12 hrs. The release kinetics of the optimized Telmisartan
loaded oil entrapped beads showed that it follows Higuchi release kinetics. The release of the drug from
the dosage form is carried out by diffusion and follows Korsmeyer peppas kinetics and the n value is
greater than 0.5 indicating non-Fickian release. The floating beads have been employed to make a
sustained release of the drug in the stomach to enhance bioavailability and to decrease dose dumping
and hence overcome its side effects. The developed formulation shows an alternative to the conventional
dosage form for the treatment of Telmisartan, a nonsedating antihistamine H1 blocker used for seasonal
allergic rhinitis and chronic idiopathic urticaria has limited absorption in the upper small intestine
with poor oral bioavailability. Hence finally it was concluded that the prepared oil entrapped floating
sodium alginate beads of Telmisartan may prove to
be potential candidate for safe and effective
sustained drug delivery over an extended period of
time which can reduce dosing frequency and
improved oral bioavailability.
n
Keywords: Gastroretentive Delivery System, Floating Alginate Beads Bioavailability, Telimisartan
n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Bioinformatics(rrjobi)]
n
n
n
n
n
nn
nn[if 992 equals=”Open Access”] Full Text PDF Download[else] nvar fieldValue = “[user_role]”;nif (fieldValue == ‘indexingbodies’) {n document.write(‘Full Text PDF‘);n }nelse if (fieldValue == ‘administrator’) { document.write(‘Full Text PDF‘); }nelse if (fieldValue == ‘rrjobi’) { document.write(‘Full Text PDF‘); }n else { document.write(‘ ‘); }n [/if 992] [if 379 not_equal=””]n
Browse Figures
n
n[/if 379]n
References
n[if 1104 equals=””]n
Mudie DM, Amidon GL, Amidon GE. Physiological parameters for oral delivery and in vitro
testing. Mol Pharm 2010;7:1388–1405.
2. Nayak AK, Malakar J, Sen KK. Gastroretentive drug delivery technologies: current approaches and
future potential. J Pharm Educ Res 2010;1:1–12.
3. Sugihara H, Matsui Y, Takeuchi H, et al. Development of a gastric retentive system as a sustained-
release formulation of pranlukast hydrate and its subsequent in vivo verification in human studies.
Eur J Pharm Sci 2014;53:62–68.
4. Thakar K, Joshi G, Sawant KK. Bioavailability enhancement of baclofen by gastroretentive floating
formulation: statistical optimization, in vitro and in vivo pharmacokinetic studies. Drug Dev Ind
Pharm 2013;39:880–888.
5. Prinderre P, Sauzet C, Fuxen C. Advances in gastro retentive drug-delivery systems. Expert Opin
Drug Deliv 2011;8:1189– 1203.
6. Kesarla RS, Vora PA, Sridhar BK, et al. Formulation and evaluation of floating tablet of H2-
receptor antagonist. Drug Dev Ind Pharm 2015;41:1499–1511.
7. Kumar R, Philip A. Gastroretentive dosage forms for prolonging gastric residence time. Int J Pharm
Med 2007;21:157–171.
8. Aoki H, Iwao Y, Mizoguchi M, et al. Clarithromycin highlyloaded gastro-floating fine granules
prepared by high-shear melt granulation can enhance the efficacy of Helicobacter pylori
eradication. Eur J Pharm Biopharm 2015;92:22–27.
9. Adebisi AO, Laity PR, Conway BR. Formulation and evaluation of floating mucoadhesive alginate
beads for targeting Helicobacter pylori. J Pharm Pharmacol 2015;67:511– 524.
10. Kim JY, Bae HJ, Choi J, et al. Efficacy of gastro-retentive forms of ecabet sodium in the treatment
of gastric ulcer in rats. Arch Pharm Res 2014;37:1053–1062.
11. Li SL, Tu XD, Mao FF. Development and pharmacokinetic study of metoprolol tartrate controlled-
release tablet remaining-floating in stomach. Yao Xue Xue Bao 1989;24:381–386.
12. Kaushik AY, Tiwari AK, Gaur A. Role of excipients and polymeric advancements in preparation
of floating drug delivery systems. Int J Pharm Investig 2015;5:1–12.
13. Ishak RA. Buoyancy-generating agents for stomach-specific drug delivery: an overview with
special emphasis on floating behavior. J Pharm Pharm Sci 2015;18:77–100.
14. Malik R, Garg T, Goyal AK, et al. Polymeric nanofibers: targeted gastro-retentive drug delivery
systems. J Drug Target 2015;23:109–124.
15. Gopalakrishnan S, Chenthilnathan A. Floating drug delivery systems: a review. J Pharm Sci
Technol 2011;3:548–554.
16. Shahaa SH, Patelb JK, Pundarikakshudua K, et al. An overview of a gastro-retentive floating drug
delivery system. Asian J Pharm Sci 2009;4:65–80.
17. Gutierrez-Rocca J, Omidian H, Shah K. Progresses in gastroretentive drug delivery systems. Bus
Brief Pharmatech 2003;15:3–6.
18. Klausner EA, Lavy E, Friedman M, et al. Expandable gastroretentive dosage forms. J Control
Release 2003;90:143– 162.
19. Pawar VK, Kansal S, Asthana S, et al. Industrial perspective of gastroretentive drug delivery
systems: physicochemical, biopharmaceutical, technological and regulatory consideration. Expert
Opin Drug Deliv 2012;9:551–565.
nn[/if 1104][if 1104 not_equal=””]n
- [foreach 1102]n t
- [if 1106 equals=””], [/if 1106][if 1106 not_equal=””],[/if 1106]
n[/foreach]
n[/if 1104]
nn
nn[if 1114 equals=”Yes”]n
n[/if 1114]
n
n
n
n
n
n
n
| Volume | |
| [if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] | |
| Received | February 8, 2024 |
| Accepted | February 12, 2024 |
| Published |
n
n
n
n
n
nn function myFunction2() {n var x = document.getElementById(“browsefigure”);n if (x.style.display === “block”) {n x.style.display = “none”;n }n else { x.style.display = “Block”; }n }n document.querySelector(“.prevBtn”).addEventListener(“click”, () => {n changeSlides(-1);n });n document.querySelector(“.nextBtn”).addEventListener(“click”, () => {n changeSlides(1);n });n var slideIndex = 1;n showSlides(slideIndex);n function changeSlides(n) {n showSlides((slideIndex += n));n }n function currentSlide(n) {n showSlides((slideIndex = n));n }n function showSlides(n) {n var i;n var slides = document.getElementsByClassName(“Slide”);n var dots = document.getElementsByClassName(“Navdot”);n if (n > slides.length) { slideIndex = 1; }n if (n (item.style.display = “none”));n Array.from(dots).forEach(n item => (item.className = item.className.replace(” selected”, “”))n );n slides[slideIndex – 1].style.display = “block”;n dots[slideIndex – 1].className += ” selected”;n }n”}]
