Uttarabasti in Female Infertility: A Retrospective Analysis of Clinical Outcomes and Safety Profile

Year : 2026 | Volume : 13 | 02 | Page :
    By

    Shivangi Sanghvi,

  • Shubha Ural,

  1. PG Scholar, Department of Prasooti Tantra Stree Roga , Sri Sri College Of Ayurvedic Sciences And Research, Bengaluru, Karnataka, India/%
  2. Associate Professor, Department of Prasooti Tantra Stree Roga , Sri Sri College Of Ayurvedic Sciences And Research, Bengaluru, Karnataka, India

Abstract

Background: Uttarabasti (UB) is a specialized Panchakarma procedure involving intrauterine instillation of medicated Sneha, classically indicated in Yonivyapad and Vandhyatwa. It facilitates targeted local drug delivery, bypassing gastrointestinal metabolism and enabling direct therapeutic action at the uterine level. In Ayurvedic understanding, UB achieves Garbhashaya Shuddhi and Apana Vata Anulomana — the two primary pathological corrections considered essential in Vandhyatwa. Infertility affects an estimated 10–15% of couples globally, with a substantial proportion seeking Ayurvedic management. Despite the widespread clinical utilization of UB, comprehensive and systematically documented retrospective institutional evidence on its multi-dimensional outcomes remains limited; therefore, retrospective evaluation provides valuable real-world insights into its clinical effectiveness, therapeutic variations, and safety profile. Objectives: To retrospectively evaluate the clinical outcomes of UB in patients with Vandhyatwa, with emphasis on conception rates, symptomatic relief, ultrasonographic changes, therapeutic drug variations, and safety profile. Materials and Methods: A retrospective observational study was conducted at the Department of Prasuti Tantra and Stree Roga, Sri Sri College of Ayurvedic Sciences and Research Hospital. Case records of female patients diagnosed with Vandhyatwa who underwent UB between March 2024 and October 2025 were retrieved from departmental digital archives, OPD/IPD registers, and Panchakarma treatment records. Of 142 records screened, a total of 98 case records fulfilling predefined inclusion and exclusion criteria were included for final analysis. Patients with incomplete documentation, concurrent major interventions, or systemic illnesses were excluded. Data were analyzed using descriptive statistics including frequency, percentage, and proportion using SPSS software. Results: An overall conception rate of 13.40% was observed, with 12.24% in Apraja Vandhyatwa and 14.58% in Sapraja Vandhyatwa. Among those who conceived (n=13), 69.23% achieved natural conception without assisted reproductive techniques. Cycle-wise analysis revealed that 38.46% of conceptions occurred after the first UB cycle. Symptomatic improvement was noted in menstrual regularity (53.06%), dysmenorrhea (38.78%), and pelvic pain (35.71%). Objective ultrasonographic improvement was observed in 75.51% of cases, including improved endometrial thickness (34.69%), folliculogenesis (28.57%), and dominant follicle rupture (22.45%). Phalasarpi was the most commonly used medicated Sneha (40.82%), followed by Mahanarayana Taila (30.61%). UB was well tolerated, with procedural events reported in only 14.29% of cases, all of which were mild and transient; no serious adverse events were recorded. Conclusion: UB demonstrated clinically meaningful benefits across symptomatic, objective, and reproductive domains in the management of Vandhyatwa. Its multi-dimensional therapeutic effects — encompassing improved conception rates, endometrial responsiveness, menstrual regularity, and reduction in pelvic symptoms — highlight its holistic mechanism of action. The procedure’s favorable safety profile, minimally invasive nature, and low cost further strengthen its role as a viable primary intervention in Ayurvedic gynecological practice. Further prospective, controlled studies with standardized protocols are warranted to validate these findings and establish a stronger evidence base for UB in reproductive medicine.

Keywords: Uttarabasti; Vandhyatwa; Female Infertility; Panchakarma; Ayurvedic Reproductive Medicine

How to cite this article:
Shivangi Sanghvi, Shubha Ural. Uttarabasti in Female Infertility: A Retrospective Analysis of Clinical Outcomes and Safety Profile. Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy. 2026; 13(02):-.
How to cite this URL:
Shivangi Sanghvi, Shubha Ural. Uttarabasti in Female Infertility: A Retrospective Analysis of Clinical Outcomes and Safety Profile. Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy. 2026; 13(02):-. Available from: https://journals.stmjournals.com/rrjoasyn/article=2026/view=244085


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Ahead of Print Subscription Original Research
Volume 13
02
Received 09/04/2026
Accepted 08/05/2026
Published 09/05/2026
Publication Time 30 Days
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