Advancements in Buccal Patch Drug Delivery Systems: A Comprehensive Review of Evaluation Parameters

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This is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.

Year : 2025 | Volume : 15 | 02 | Page :
    By

    Gagandeep Kaur,

  • Navdeep Kaur,

  • Mamta Verma,

  • Harshdeep,

  • Bhawna,

  1. Assistant professor, CT Group of Institutions, Punjab, India
  2. Assistant professor, CT Group of Institutions, Punjab, India
  3. Assistant professor, CT Group of Institutions, Punjab, India
  4. Assistant professor, CT Group of Institutions, Punjab, India
  5. Assistant professor, CT Group of Institutions, Punjab, India

Abstract

The most dependable delivery method is buccal patches because it offers many improvements over alternative methods.This delivery method circumvents the hepatic first pass metabolism to deliver the medication into the systemic circulation. Buccal patches are inserted between the cheek and gums, where they dissolve and absorb through the buccal cavity’s mucosal membrane. Polymers can be used to control the drug’s delivery, and intelligent polymeric systems are a good option for creating patches. The solving casting method is frequently utilised to create patches, but more sophisticated techniques like electrospinning and electrospraying may be better options. These techniques offer benefits like increased loading capacity, multiple drug delivery, improved drug encapsulation efficiency, and increased rate of dissolution. This method can yield patches with a long mucosal layer residence time and good patient compliance.This review article explains the various ingredients that can be used to make buccal patches. It also explains the various methods that can be used to prepare the patches and the various techniques that can be used to assess the finished product. The purpose of this article is to provide readers with an overview of the ingredients, component selection, formulation process, and evaluation techniques for buccal patches.

Keywords: buccal patches, Drug Absorption, drug delivery, Reservoir System, Polymer

How to cite this article:
Gagandeep Kaur, Navdeep Kaur, Mamta Verma, Harshdeep, Bhawna. Advancements in Buccal Patch Drug Delivery Systems: A Comprehensive Review of Evaluation Parameters. OmniScience: A Multi-disciplinary Journal. 2025; 15(02):-.
How to cite this URL:
Gagandeep Kaur, Navdeep Kaur, Mamta Verma, Harshdeep, Bhawna. Advancements in Buccal Patch Drug Delivery Systems: A Comprehensive Review of Evaluation Parameters. OmniScience: A Multi-disciplinary Journal. 2025; 15(02):-. Available from: https://journals.stmjournals.com/osmj/article=2025/view=234908


References

1. Amir H et al: Systemic drug delivery via the buccal mucosal route, Pharmaceutical technology. 2001: 1-27.

2. Ul haq, Deepthi K.: Areview article on buccal patches: Formulation and evaluation, International jornal of pharmaceutical research and applications. 2021, 679-682.

3. Aungst BJ and Rogers NJ: Site Dependence of AbsorptionPromoting Actions of Laureth, Na Salicylate, Na2EDTA, and Aprotinin on Rectal, Nasal, and Buccal Insulin Delivery, Pharm Res 1988: 5 (5); 305–308.

4. Michael JR, Ian GT. Mechanisms, barriers and pathways of oral mucosal drug permeation. Adv Drug Del Rev 1993; 12:41-60.

5. Steward A et al: The Effect of Enhancers on the Buccal Absorption of Hybrid (BDBB) Alpha-Interferon.IntJ Pharm 1994: 104: 145–149.

6. Bernkop-Schnurch A. Novel bioadhesive chitosan-EDTA conjugate protects leucine enkephalin from degradation by aminopeptidase. N. Pharm. Res.1997;14:917–922.

7. Koyi K. Khan B.A. : Buccal patches: A review, International journla of pharmaceutical sciebces and reseasrch.

8. Pramodkumar TM et al: Oral transmucosal drug delivery systems. Indian drug 2004: 41(2);63-112.

9. H. Sohi, A. Ahuja, F.J. Ahmad, R.K. Khar, Critical evaluation of permeation enhancers for oral mucosal drug delivery, Drug Dev. Ind. Pharm. 36 (3) (2010) 254–282.

10. N.S. Madhav, A.K. Shakya, P. Shakya, K. Singh, Orotransmucosal drug delivery systems: a review, J. Control. Release 140 (1) (2009) 2–11.

11. M. Montenegro-Nicolini, J.O. Morales, Overview and future potential of buccal mucoadhesive films as drug delivery systems for biologics, AAPS PharmSciTech 18 (1) (2017) 3–14.

12. N. Salamat-Miller, M. Chittchang, T.P. Johnston, The use of mucoadhesive polymers in buccal drug delivery, Adv. Drug Deliv. Rev. 57 (11) (2005) 1666–1691.

13. A. Puratchikody, V. Prasanth, S.T. Mathew, A. Kumar, Buccal drug delivery: past, present and future-a review, Int. J. Drug Deliv. 3 (2) (2011) 171.

14. R.A. Siegel, M.J. Rathbone, Overview of controlled release mechanisms, Fundamentals and Applications of Controlled Release Drug Delivery, Springer, 2012, pp. 19–43.

15. Kothiyal P., Kumar G. A review article: Recent Approaches in Buccal patches , The pharma innovation 2012 Vol.1 No. 7.

16. M.R. Jimenez-Castellanos, H. Zia, C.T. Rhodes, Mucoadhesive drug delivery systems, Drug Dev. Ind. Pharm. 19 (1993) 143–194.

17. Y. Sudhakar, K. Kuotsu, A.K. Bandyopadhyay, Buccal bioadhesive drug delivery: a promising option for orally less efficient drugs, J. Control. Release 114 (2006) 15–40.

18. M.E. Imam, M. Hornof, C. Valenta, G. Reznicek, A.B. Schnurch, Evidence for the interpretation of mucoadhesive polymers into the mucus gel layer, STP Pharm. Sci. 13 (2003) 171–176.

19. M.I. Ugwoke, R.U. Agu, N. Verbeke, R. Kinget, Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives, Adv. Drug Deliv. Rev. 57 (2005) 1640–1665.

20. H. Sigurdsson, T. Loftsson, C. Lehr, Assessment of mucoadhesion by a resonant mirror biosensor, Int. J. Pharm. 325 (2006) 75–81

21. J.W. Lee, J.H. Park, J.R. Robinson, Bioadhesive based dosage forms: the next generation, J. Pharm. Sci. 89 (2000) 850–866.

22. Y. Huang, W. Leobandung, A. Foss, N.A. Peppas, Molecular aspects of mucoadhesion and bioadhesion: tethered structures and site specific surfaces, J. Control. Release 65 (2000) 63–71.

23. G.P. Andrews, T.P. Laverty, D.S. Jones, Mucoadhesive polymeric platforms for controlled drug delivery, Eur. J. Pharm. Biopharm. 71 (2009) 505–518.

24. P. He, S. Davis, L. Illum, In vitro evaluation of the mucoadhesive properties of chitosan microsphere

25. A. Ludwig, The use of mucoadhesive polymers in ocular drug delivery, Adv. Drug Deliv. Rev. 57 (2005) 1595–1639

26. P. Schattling, F.D. Jochum, P. Theato, Multi-stimuli responsive polymers–the all- inone talents, Poly. Chem.5(1), 2014, 25-36.

27. A. Bashari, A. Rouhani Shirvan, M. Shakeri, Cellulose-based hydrogels for personal care products, Polym. Adv. Technol. 29 (12) (2018) 2853–2867.

28. Qaiser R., Pervaiz F. : Mucoadhesive chitosan/ polyvinnylpyrrolidone-co-poly (2- acrylamide-2-methyl propane sulphonic acid) based hydrogels of captopril with adjustable properties as sustained release carrier: Formulation design and toxicological evaluation, Journal of drug delivery science and technology, 2023, Vol. 81.

29. Vakili R.M. , Saeid M.W. : Development of mucoadhesive hydrogels based on polyacrylic acid grafted cellulose nanocrystals for local cisplatin delivery, ELSEVIER, 2021, vol. 255.

30. H.A. El Azim, N. Nafee, A. Ramadan, N. Khalafallah, Liposomal buccal mucoadhesive film for improved delivery and permeation of water-soluble vitamins, Int. J. Pharm. 488 (1–2) (2015) 78–85.

31. V. Erjavec, Z. Pavlica, M. Sentjurc, M. Petelin, In vivo study of liposomes as drug carriers to oral mucosa using EPR oximetry, Int. J. Pharm. 307 (1) (2006) 1–8 .

32. Azim H., Nafee N., : Liposomal buccal mucoadhesive films for improved delivery and permeation of water soluble vitamins.

33. W. Xu, P. Ling, T. Zhang, Polymeric micelles, a promising drug delivery system to enhance bioavailability of poorly water-soluble drugs, J. Drug Deliv. 2013 (2013)

34. M.-C. Jones, M. Ranger, J.-C. Leroux, pH-sensitive unimolecular polymeric micelles: synthesis of a novel drug carrier, Bioconjug. Chem. 14 (4) (2003) 774–781.

35. A. Semalty, M. Bhojwani, G. Bhatt, G. Gupta, A. Shrivastava, Design and evaluation of mucoadhesive baccal films of diltiazem hydrochloride, Indian J. Pharmaceut. Sci. 67 (5) (2005) 548.

36. Arpa M., Okur N. :Chitosan based buccal mucoadhesive patches to enhance the systemic biavailability of tizanidine, International journal of Pharmaceutics, 2023, Vol. 642.

37. Govindasamy P., Kesavan B. : Formulation of unidirectional release buccal patches of carbamazepine and study permeation through porcine buccal mucosa, Asian pacific journal of tropical biomedicine, 2013, Vol.3.

38. Shiledar R., Tagalpallewar A.: Formulation and in-vitro evaluation of xanthan gum- based bilayered mucoadhesive buccal patches of zolmitriptan, ELSEVIER SCI, 2014.

39. Teotia D. , Kumar K. : Acomprehensive review on buccal patches, GSC biological and pharmaceutical sciences, 2020, 130-135.

40. A. Baji, Y.-W. Mai, S.-C. Wong, M. Abtahi, P. Chen, Electrospinning of polymer nanofibers: effects on oriented morphology, structures and tensile properties, Compos. Sci. Technol. 70 (5) (2010) 703–718.

41. X. Wang, H. Niu, X. Wang, and T. Lin, “Needle electrospinning of uniform nanofibres using spiral coil spinnerets,” Journal of Nanomaterials, vol. 2012, 9 pages 2012.

42. R. S. Bhattarai, R. D. Bachu, S. H. S. Boddu, and S. Bhaduri, “Biomedical applications of electrospun nanofibers: drug and nanoparticle delivery,” Pharmaceutics, vol. 11, pp. 1–10, 2019.

43. Nazari K., Ahmad R. : Development and characterisation of cellulose based electrospun mats for buccal delivery of non-steroidal anti-inflammatory drug (NSAID), European journal of pharmaceutical sciences, Volume 102, 2017, 147-155

44. Mann G., Gurave P. : Polymeric and electrospun patches for drug delivery through buccal route: Formulation and biointerface evaluation, Journal of drug delivery science and technology, Volume 68, 2022.

45. Edmans J., Ollington B.: Electrospun patch delivery of anti-TNFα F(ab) for the treatment of inflammatory oral mucosal disease, Jpurnal of controlled release, Vol. 350, 2022, 146-157

46. Shrivan A., Bashari A.: New insight into the fabrication of smart mucoadhesive buccal patches as a novel controlled-drug delivery system, European polymer journal, 2019, 541-550.

47. A. Subramanian, D. Vu, G.F. Larsen, H.-Y. Lin, Preparation and evaluation of the electrospun chitosan/PEO fibers for potential applications in cartilage tissue engineering, J. Biomater. Sci. Polym. Ed. 16 (7) (2005) 861–873.

48. L. Francis, J. Venugopal, M.P. Prabhakaran, V. Thavasi, E. Marsano, S. Ramakrishna, Simultaneous electrospin–electrosprayed biocomposite nanofibrous scaffold for bone tissue regeneration, Acta Biomater. 6(10), 2010, 4100-4109.

49. Verma N. Wahi A. : Evaluation of a mucoadhesive buccal patch for delivery of atenolol: in vitro screening of bioadhesion, Pure Appl Microbiol, 1, 2007, 115-118.

50. Pendekal M., Tegginamat P. : Formulation and evaluation of a bioadhesive patch for buccal delivery of tizanidine, Acta pharmaceutics sinica B, Vol. 2, 2012 318-324.

51. Nafee N. , Boraie M. : Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride, Acta Pharm,53(2003), pp.199-212

52. Speer I., Preis M. : Dissolution testing of oral film preparations: experimental comparison of compendial and non-compendial methods, Int. J. Pharm.,561(2019 Apr), pp.124-134

Ahead of Print Subscription Review Article
Volume 15
02
Received 04/09/2024
Accepted 04/09/2025
Published 27/12/2025
Publication Time 479 Days
135

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