Phytochemicals from Plectranthus amboinicus and Azadirachta indica for Promoting Angiogenesis and Tissue Regeneration – A Short Review

Year : 2025 | Volume : 27 | Issue : 02 | Page : 34 40
    By

    Mrunal,

  • Heeba,

  • Niveditha,

  1. Student, Department of Biotechnology, Institute of Science, Dr Homi Baba State University, Mumbai, Maharashtra, India
  2. Student, Department of Biotechnology, Institute of Science, Dr Homi Baba State University, Mumbai, Maharashtra, India
  3. Professor, Department of Biotechnology, Institute of Science, Dr Homi Baba State University, Mumbai, Maharashtra, India

Abstract

The eco-friendly synthesis of silver nanoparticles (AgNPs) using plant extracts has garnered significant attention due to its potential in biomedical applications. This review highlights the green synthesis methodologies, focusing on Plectranthus amboinicus and Azadirachta indica, their phytochemical components, and their docking studies with angiogenesis-related receptors such as VEGF and FGF. The applications of AgNPs in tissue regeneration, wound healing, and angiogenesis are discussed in detail, emphasizing the roles of phytochemicals like carvacrol, thymol, nimbolide, and quercetin. Additionally, existing studies on green-synthesized nanoparticle-incorporated scaffolds for tissue regeneration are reviewed. Insights into the mechanisms of nanoparticle formation and bioactivity are also explored. Challenges, future perspectives, and the potential integration of nanotechnology in regenerative medicine are addressed.

Keywords: Green synthesis, phytochemicals, nanoparticles, VEGF receptor, tissue regeneration

[This article belongs to Nano Trends – A Journal of Nano Technology & Its Applications ]

How to cite this article:
Mrunal, Heeba, Niveditha. Phytochemicals from Plectranthus amboinicus and Azadirachta indica for Promoting Angiogenesis and Tissue Regeneration – A Short Review. Nano Trends – A Journal of Nano Technology & Its Applications. 2025; 27(02):34-40.
How to cite this URL:
Mrunal, Heeba, Niveditha. Phytochemicals from Plectranthus amboinicus and Azadirachta indica for Promoting Angiogenesis and Tissue Regeneration – A Short Review. Nano Trends – A Journal of Nano Technology & Its Applications. 2025; 27(02):34-40. Available from: https://journals.stmjournals.com/nts/article=2025/view=204257


References

  1.  Skalsky K, Yahav D, Bishara J, Pitlik S, Leibovici L, Paul M. Treatment of humanbrucellosis: systematic review and meta-analysis of randomised controlled trials. Bmj. 2008 Mar 27;336(7646):701-4.
  2. Hanna JN, McBride WJ, Brookes DL, Shield J, Taylor CT, Smith IL, Craig SB, Smith GA.Hendra virus infection in a veterinarian. The Medical Journal of Australia. 2006 Nov 20;185(10):562.
  3. Fletcher D, Wagstaff CR. Organizational psychology in elite sport: Its emergence, application and future. Psychology of sport and exercise. 2009 Jul 1;10(4):427-34.
  4.  Sharma VK, Yngard RA, Lin Y. Silver nanoparticles: green synthesis and their antimicrobial
    activities. Advances in colloid and interface science. 2009 Jan 30;145(1-2):83-96.
  5. Prabhu S, Poulose EK. Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects. International nano letters. 2012 Dec;2:1-0.
  6.  Rai M, Yadav A, Gade A. Silver nanoparticles as a new generation of antimicrobials. Biotechnology advances. 2009 Jan 1;27(1):76-83.
  7. Ezeh CK, Eze CN, Dibua MU, Emencheta SC. A review on Azadirachta indica (neem) plant mediated biosynthesis, characterisation and antimicrobial activity of silver nanoparticles. International Journal of Biomedical Nanoscience and Nanotechnology. 2024;5(1):15-36.
  8.  Shankar SS, Rai A, Ahmad A, Sastry M. Rapid synthesis of Au, Ag, and bimetallic Au core–Ag shell nanoparticles using Neem (Azadirachta indica) leaf broth. Journal of colloid and interface science. 2004 Jul 15;275(2):496-502.
  9. Mittal AK, Chisti Y, Banerjee UC. Synthesis of metallic nanoparticles using plant extracts. Biotechnology advances. 2013 Mar 1;31(2):346-56.
  10.  Raj S, Jose S, Sumod US, Sabitha M. Nanotechnology in cosmetics: Opportunities and challenges. Journal of Pharmacy and Bioallied Sciences. 2012 Jul 1;4(3):186-93.
  11. 11. Singh P, Kim YJ, Zhang D, Yang DC. Biological synthesis of nanoparticles from plants and
    microorganisms. Trends in biotechnology. 2016 Jul 1;34(7):588-99.
  12.  Iravani S. Green synthesis of metal nanoparticles using plants. Green chemistry. 2011;13(10):2638-50.
  13.  Bar H, Bhui DK, Sahoo GP, Sarkar P, De SP, Misra A. Green synthesis of silver nanoparticles using latex of Jatropha curcas. Colloids and surfaces A: Physicochemical and engineering aspects. 2009 May 1;339(1-3):134-9.
  14. Nabikhan A, Kandasamy K, Raj A, Alikunhi NM. Synthesis of antimicrobial silver nanoparticles by callus and leaf extracts from saltmarsh plant, Sesuvium portulacastrum L. Colloids and surfaces B: Biointerfaces. 2010 Sep 1;79(2):488-93.

15.  Huang J, Li Q, Sun D, Lu Y, Su Y, Yang X, Wang H, Wang Y, Shao W, He N, Hong J. Biosynthesis of silver and gold nanoparticles by novel sundried Cinnamomum camphoraleaf. Nanotechnology. 2007 Feb 6;18(10):105104.
16. El-Seedi HR, El-Shabasy RM, Khalifa SA, Saeed A, Shah A, Shah R, Iftikhar FJ, Abdel-Daim MM, Omri A, Hajrahand NH, Sabir JS. Metal nanoparticles fabricated by green chemistry using natural extracts: Biosynthesis, mechanisms, and applications. RSC advances. 2019;9(42):24539-59.
17. Sondi I, Salopek-Sondi B. Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. Journal of colloid and interface science. 2004 Jul 1;275(1):177-82.
18. Jha AK, Prasad K, Prasad K, Kulkarni AR. Plant system: nature’s nanofactory. Colloids and Surfaces B: Biointerfaces. 2009 Oct 15;73(2):219-23

19. Kumar V, Yadav SK. Plant‐mediated synthesis of silver and gold nanoparticles and their applications. Journal of Chemical Technology & Biotechnology: International Research in Process, Environmental & Clean Technology. 2009 Feb;84(2):151-7.

20. Saxena A, Tripathi RM, Zafar F, Singh P. Green synthesis of silver nanoparticles using aqueous solution of Ficus benghalensis leaf extract and characterization of their antibacterial
activity. Materials letters. 2012 Jan 15;67(1):91-4.

21. Behravan M, Panahi AH, Naghizadeh A, Ziaee M, Mahdavi R, Mirzapour A. Facile green synthesis of silver nanoparticles using Berberis vulgaris leaf and root aqueous extract and its antibacterial activity. International journal of biological macromolecules. 2019 Mar 1;124:148-54.

22. Amini SM. Preparation of antimicrobial metallic nanoparticles with bioactive compounds. Materials Science and Engineering: C. 2019 Oct 1;103:109809.

23. Jacob SJ, Finub JS, Narayanan A. Synthesis of silver nanoparticles using Piper longum leaf extracts and its cytotoxic activity against Hep-2 cell line. Colloids and Surfaces B: Biointerfaces. 2012 Mar 1;91:212-4.

24. Rao YS, Kotakadi VS, Prasad TN, Reddy AV, Gopal DS. Green synthesis and spectral characterization of silver nanoparticles from Lakshmi tulasi (Ocimum sanctum) leaf extract. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2013 Feb 15;103:156-9.

25. Gurunathan S, Han JW, Kwon DN, Kim JH. Enhanced antibacterial and anti-biofilm activities of silver nanoparticles against Gram-negative and Gram-positive bacteria. Nanoscale research letters. 2014 Dec;9:1-7.

26. Ahmed S, Ahmad M, Swami BL, Ikram S. Green synthesis of silver nanoparticles using Azadirachta indica aqueous leaf extract. Journal of radiation research and applied sciences. 2016 Jan 1;9(1):1-7.

27. Anandalakshmi K, Venugobal J, Ramasamy VJ. Characterization of silver nanoparticles by green synthesis method using Pedalium murex leaf extract and their antibacterial activity. Applied nanoscience. 2016 Mar;6:399-408.

28. Zargar M, Hamid AA, Bakar FA, Shamsudin MN, Shameli K, Jahanshiri F, Farahani F. Green synthesis and antibacterial effect of silver nanoparticles using Vitex negundo L. Molecules. 2011 Aug 8;16(8):6667-76.

29. Raut RW, Kolekar NS, Lakkakula JR, Mendhulkar VD, Kashid SB. Extracellular synthesis of silver nanoparticles using dried leaves of Pongamia pinnata (L) pierre. Nano-Micro Letters. 2010 Jun;2:106-13.

30. Kalimuthu K, Babu RS, Venkataraman D, Bilal M, Gurunathan S. Biosynthesis of silver nanocrystals by Bacillus licheniformis. Colloids and surfaces B: Biointerfaces. 2008 Aug 1;65(1):150-3.

31. Kora AJ, Arunachalam J. Green fabrication of silver nanoparticles by gum tragacanth (Astragalus gummifer): a dual functional reductant and stabilizer. Journal of Nanomaterials. 2012;2012(1):869765.

32. Ali K, Dwivedi S, Azam A, Saquib Q, Al-Said MS, Alkhedhairy AA, Musarrat J. Aloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates. Journal of colloid and interface science. 2016 Jun 15;472:145-56.

33. Durán N, Marcato PD, De Souza GI, Alves OL, Esposito E. Antibacterial effect of silver nanoparticles produced by fungal process on textile fabrics and their effluent treatment. Journal of biomedical nanotechnology. 2007 Jun 1;3(2):203-8.

34. Gade AK, Bonde P, Ingle AP, Marcato PD, Duran N, Rai MK. Exploitation of Aspergillus niger for synthesis of silver nanoparticles. Journal of Biobased Materials and Bioenergy. 2008 Sep 1;2(3):243-7.
35. Jaidev LR, Narasimha G. Fungal mediated biosynthesis of silver nanoparticles, characterization and antimicrobial activity. Colloids and surfaces B: Biointerfaces. 2010 Dec 1;81(2):430-3.
36. Salem SS, Fouda MM, Fouda A, Awad MA, Al-Olayan EM, Allam AA, Shaheen TI. Antibacterial, cytotoxicity and larvicidal activity of green synthesized selenium nanoparticles using Penicillium corylophilum. Journal of Cluster Science. 2021 Mar;32:351-61.
37. Yazhiniprabha M, Vaseeharan B. In vitro and in vivo toxicity assessment of selenium nanoparticles with significant larvicidal and bacteriostatic properties. Materials Science and Engineering: C. 2019 Oct 1;103:109763.
38. Ankamwar B, Damle C, Ahmad A, Sastry M. Biosynthesis of gold and silver nanoparticles using Emblica officinalis fruit extract, their phase transfer and transmetallation in an organic solution. Journal of nanoscience and nanotechnology. 2005 Oct 1;5(10):1665-71.
39. Ghosh S, Patil S, Ahire M, Kitture R, Jabgunde A, Kale S, Pardesi K, Bellare J, Dhavale DD, Chopade BA. Synthesis of gold nanoanisotrops using Dioscorea bulbifera tuber extract. Journal of Nanomaterials. 2011;2011(1):354793.
40. Reddy NJ, Vali DN, Rani M, Rani SS. Evaluation of antioxidant, antibacterial and cytotoxic effects of green synthesized silver nanoparticles by Piper longum fruit. Materials Science and Engineering: C. 2014 Jan 1;34:115-22.

Regular Issue Subscription Review Article
Volume 27
Issue 02
Received 10/01/2025
Accepted 11/02/2025
Published 20/03/2025
Publication Time 69 Days
184

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