A Comprehensive Review: Emerging Nanotechnology in Cancer Drug Delivery

Year : 2025 | Volume : 27 | Issue : 01 | Page : 24-33
    By

    Mohd. Wasiullah,

  • Piyush Yadav,

  • Shivanand Yadav,

  • Sumit Yadav,

  1. Principal, Department of Pharmacy, Prasad Institute Technology, Jaunpur, Uttar Pradesh, India
  2. Academic Head, Department of Pharmacy, Prasad Institute of Technology, Jaunpur (222001), Uttar Pradesh, India
  3. Assistant Professor, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  4. Scholar, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India

Abstract

Nanotechnology has become a groundbreaking strategy in cancer therapy, especially in drug delivery systems, offering improved treatment effectiveness while minimizing the adverse effects associated with traditional methods. This review presents an in-depth analysis of recent progress in nanotechnology for cancer drug delivery, emphasizing the design, mechanisms, and practical applications of nanoparticle-based systems. Nanoparticles, such as liposomes, dendrimers, and gold nanoparticles, offer unique advantages, including improved drug solubility, targeted delivery to tumor cells, and controlled release of therapeutic agents. These systems can be designed to target cancerous tissues specifically, reducing harm to healthy cells and substantially enhancing the therapeutic index. The review also highlights varioufis strategies for achieving targeted drug delivery, such as passive targeting via the enhanced permeability and retention effect, and active targeting using surface modifications like antibodies or ligands that bind specifically to cancer cell receptors. Moreover, incorporating imaging functionalities into nanoparticles enables real-time tracking of treatment progress and evaluation of tumor response. The potential of multifunctional nanoparticles, which can combine drug delivery, imaging, and treatment monitoring, is also explored. Despite the promising benefits, challenges related to nanoparticle stability, scaling up production, and regulatory hurdles remain. This review concludes by discussing future directions for research and development in cancer nanomedicine, emphasizing the need for personalized treatment strategies and the continued evolution of nanotechnology to improve patient outcomes

Keywords: Nanotechnology, anti-tumor drug delivery, nanoparticles, controlled release, personalized medicine

[This article belongs to Nano Trends – A Journal of Nano Technology & Its Applications ]

How to cite this article:
Mohd. Wasiullah, Piyush Yadav, Shivanand Yadav, Sumit Yadav. A Comprehensive Review: Emerging Nanotechnology in Cancer Drug Delivery. Nano Trends – A Journal of Nano Technology & Its Applications. 2025; 27(01):24-33.
How to cite this URL:
Mohd. Wasiullah, Piyush Yadav, Shivanand Yadav, Sumit Yadav. A Comprehensive Review: Emerging Nanotechnology in Cancer Drug Delivery. Nano Trends – A Journal of Nano Technology & Its Applications. 2025; 27(01):24-33. Available from: https://journals.stmjournals.com/nts/article=2025/view=192092



References

  1. Hartland A, Lead JR, Slaveykova VI, O’Carroll D, Valsami-Jones E. The environmental significance of natural nanoparticles. Nature Education Knowledge. 2013;4(8):7.
  2. Johnston LJ, Gonzalez-Rojano N, Wilkinson KJ, Xing B. Key challenges for evaluation of the safety of engineered nanomaterials. NanoImpact. 2020;18:100219. doi: 10.1016/j.impact.2020.100219.
  3. Jeevanandam J, Barhoum A, Chan YS, Dufresne A, Danquah MK. Review on nanoparticles and nanostructured materials: History, sources, toxicity and regulations. Beilstein J Nanotechnol. 2018;9(1):1050–1074. doi: 10.3762/bjnano.9.98.
  4. Yadav HK, Almokdad AA, Sumia IM, Debe MS. Polymer-based nanomaterials for drug-delivery carriers. In: Nanocarriers for drug delivery. Elsevier; 2019. pp. 531–556.
  5. Ramasamy T, Tran TH, Cho HJ, Kim JH, Kim YI, Jeon JY, et al. Chitosan-based polyelectrolyte complexes as potential nanoparticulate carriers: physicochemical and biological characterization. Pharm Res. 2014;31(5):1302–1314. doi: 10.1007/s11095-013-1251-9.
  6. Shameli K, Bin Ahmad M, Jaffar Al-Mulla EA, Ibrahim NA, Shabanzadeh P, Rustaiyan A, et al. Green biosynthesis of silver nanoparticles using Callicarpa maingayi stem bark extraction. Molecules. 2012;17(7):8506–8517. doi: 10.3390/molecules17078506.
  7. Daniyal M, Liu B, Wang W. Comprehensive review on graphene oxide for use in drug delivery system, Curr Med Chem. 2020;27(22):3665–3685. doi: 10.2174/13816128256661902011296290.
  8. Hosseini SM, Mohammadnejad J, Salamat S, Zadeh ZB, Tanhaei M, Ramakrishna S. Theranostic polymeric nanoparticles as a new approach in cancer therapy and diagnosis: A review. Mater Today Chem. 2023;29(4):101400. doi: 10.1016/j.mtchem.2023.101400.
  9. Zoi V, Giannakopoulou M, Alexiou GA, Bouziotis P, Thalasselis S, Tzakos AG, et al. Nuclear medicine and cancer theragnostics: Basic concepts. Diagnostics. 2023;13(19):3064. doi: 10.3390/diagnostics13193064.
  10. Indoria S, Singh V, Hsieh MF. Recent advances in theranostic polymeric nanoparticles for cancer treatment: A review. Int J Pharm. 2020;582:119314. doi: 10.1016/j.ijpharm.2020.119314.
  11. Chehelgerdi M, Chehelgerdi M, Allela OQ, Pecho RD, Jayasankar N, Rao DP, et al. Progressing nanotechnology to improve targeted cancer treatment: Overcoming hurdles in its clinical implementation. Mol Cancer. 2023;22(1):169. doi: 10.1186/s12943-023-01865-0.
  12. Allen TM, Cullis PR. Liposomal drug delivery systems: From concept to clinical applications. Adv Drug Deliv Rev. 2013;65(1):36–48. doi: 10.1016/j.addr.2012.09.037.
  13. Bonartsev AP, Bonartseva GA, Reshetov IV, Kirpichnikov MP, Shaitan KV. Application of polyhydroxyalkanoates in medicine and the biological activity of natural poly (3-hydroxybutyrate). Acta Naturae. 2019;11(2):4–16. doi: 10.32607/20758251-2019-11-2-4-16.
  14. Sarode RJ, Mahajan HS. Dendrimers for drug delivery: An overview of its classes, synthesis, and applications. J Drug Del Sci Tech. 2024:105896. doi: 1016/j.jddst.2024.105896.
  15. Jeong WY, Kwon M, Choi HE, Kim KS. Recent advances in transdermal drug delivery systems: A review. Biomater Res. 2021;25(1):24. doi: 10.1186/s40824-021-00226-6.
  16. Ruiz Ciancio D, Vargas MR, Thiel WH, Bruno MA, Giangrande PH, Mestre MB. Aptamers as diagnostic tools in cancer. Pharmaceuticals (Basel). 2018;11(3):86. doi: 10.3390/ph11030086.
  17. Jain RK. Transport of molecules, particles, and cells in solid tumors. Annu Rev Biomed Eng. 1999;1:241–263. doi: 10.1146/annurev.bioeng.1.1.241.
  18. Torchilin V. Tumor delivery of macromolecular drugs based on the EPR effect. Adv Drug Deliv Rev. 2011;63(3):131–135. doi: 10.1016/j.addr.2010.03.011.
  19. Yap KM, Sekar M, Fuloria S, Wu YS, Gan SH, Mat Rani NN, et al. Drug delivery of natural products through nanocarriers for effective breast cancer therapy: A comprehensive review of literature. Int J Nanomedicine. 2021;16:7891–7941. doi: 10.2147/IJN.S328135.
  20. Huang H, Liu R, Yang J, Dai J, Fan S, Pi J, et al. Gold nanoparticles: Construction for drug delivery and application in cancer immunotherapy. Pharmaceutics. 2023;15(7):1868. doi: 10.3390/pharmaceutics15071868.
  21. Ferrari M. Frontiers in cancer nanomedicine: Directing mass transport through biological barriers. Trends Biotechnol. 2010;28(4):181–188. doi: 10.1016/j.tibtech.2009.12.007.
  22. Tran P, Lee SE, Kim DH, Pyo YC, Park JS. Recent advances of nanotechnology for the delivery of anticancer drugs for breast cancer treatment. J Pharm Investig. 2020;50:261–270. doi: 10.1007/s40005-019-00459-7.
  23. Liu P, Chen G, Zhang J. A review of liposomes as a drug delivery system: current status of approved products, regulatory environments, and future perspectives. Molecules. 2022;27(4):1372. doi: 10.3390/molecules27041372.
  24. Xu J, Cao W, Wang P, Liu H. Tumor-derived membrane vesicles: A promising tool for personalized immunotherapy. Pharmaceuticals (Basel). 2022;15(7):876. doi: 10.3390/ph15070876.
  25. Zafar MS, Amin F, Fareed MA, Ghabbani H, Riaz S, Khurshid Z, et al. Biomimetic aspects of restorative dentistry biomaterials. Biomimetics (Basel). 2020;5(3):34.  doi: 10.3390/biomimetics5030034.
  26. Shahbazi MA, Shrestha N, Pierchala MK, Kadumudi FB, Mehrali M, Hasany M, et al. A self-healable, moldable and bioactive biomaterial gum for personalised and wearable drug delivery. J Mater Chem B. 2020;8(19):4340–4356. doi: 10.1039/c9tb02156f.
  27. Choi HK, Choi MY, Haizan I, Choi JH. Plasmonic Nanobiosensors for Early Diagnosis of Cancers. In: Handbook of Cancer and Immunology. 2024. pp. 1–49.
  28. Hernández Becerra E, Quinchia J, Castro C, Orozco J. Light-triggered polymersome-based anticancer therapeutics delivery. Nanomaterials (Basel). 2022;12(5):836. doi: 10.3390/nano12050836.
Regular Issue Subscription Review Article
Volume 27
Issue 01
Received 14/12/2024
Accepted 30/12/2024
Published 03/01/2025
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