P. Remya,
- Professor, Department of Chemistry, Mailam Engineering College, Mailam, Tamil Nadu, India
Abstract
Analytical chemistry is critical to scientific study because it allows for the accurate identification, measurement, and characterization of chemical compounds. Recent advances in methodology have improved accuracy, sensitivity, and efficiency, with techniques such as High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), Mass Spectrometry (MS), and Nuclear Magnetic Resonance (NMR) spectroscopy transforming analytical procedures. The combination of Artificial Intelligence (AI) and Machine Learning (ML) has enhanced data processing, pattern recognition, and automation while reducing human error and increasing reproducibility. Green analytical chemistry is gaining importance, promoting sustainable practices such as solvent reduction, eco-friendly reagents, and miniaturized techniques to reduce environmental impact. Additionally, microfluidic and lab-on-a-chip technologies enable real-time, portable, and high-throughput analysis, benefiting pharmaceuticals, environmental monitoring, food safety, and forensic science. Despite these advancements, challenges like standardization, cost, and instrumentation complexity persist. This paper explores recent trends in analytical chemistry, emphasizing technological innovations, applications, and future prospects of this rapidly evolving field.
Keywords: Analytical chemistry, chromatography, spectroscopy, artificial intelligence, green chemistry
[This article belongs to Journal of Thin Films, Coating Science Technology & Application ]
P. Remya. Advances in Analytical Chemistry Research Methodology: Trends and Applications. Journal of Thin Films, Coating Science Technology & Application. 2025; 12(02):10-18.
P. Remya. Advances in Analytical Chemistry Research Methodology: Trends and Applications. Journal of Thin Films, Coating Science Technology & Application. 2025; 12(02):10-18. Available from: https://journals.stmjournals.com/jotcsta/article=2025/view=215739
References
- Harris DC. Quantitative Chemical Analysis. W. H. Freeman; 2015.
- Skoog DA, Holler FJ, Crouch SR. Principles of Instrumental Analysis. Cengage Learning; 2018.
- Leardi R. Artificial intelligence in analytical chemistry: A review. Anal Chim Acta. 2019;1051:10–30.
- dos Santos WTP, da Silva ABF. Machine learning applications in chromatography. J Chromatogr A. 2020;1620:461010.
- Koel M. Green Analytical Chemistry: Theory and Practice. Royal Society of Chemistry; 2016.
- Armenta S, Garrigues S, de la Guardia M. Green analytical chemistry. TrAC Trends Anal Chem. 2020;124:115833.
- van de Voorde M, Soloviev A. Instrumentation and Sensors for the Food Industry. Springer; 2021.
- Azzouz A, Kailasa SK, Lee SS, Ballesteros E. Advances in miniaturized analytical techniques for environmental analysis. Talanta. 2021;233:122497.
- Stoytcheva M, Zlatev R. Analytical Chemistry: Developments, Applications, and Challenges. CRC Press; 2020.
- Chassaing C, Guillarme D. Recent advances in UHPLC for pharmaceutical analysis. J Pharm Biomed Anal. 2021;194:113765.
- Smith E, Dent G. Modern Raman Spectroscopy: A Practical Approach. John Wiley & Sons; 2019.
- Araujo P, Gonzalez J. Applications of IR spectroscopy in forensic and food science. Anal Methods. 2020;12(3):450–65.
- Whitesides GM. The origins and the future of microfluidics. Nature. 2018;442(7101):368–73.
- Sackmann EK, Fulton AL, Beebe DJ. The present and future role of microfluidics in biomedical research. Nat Rev Drug Discov. 2020;13(6):371–87.
- Gil B, Jensen KF. Automation in analytical chemistry: Challenges and prospects. Anal Chim Acta. 2021;1158:338412.
- Goodacre R, Kell DB. Artificial intelligence in metabolomics and analytical chemistry. Bioinformatics. 2019;35(6):1017–25.
- Martens H, Næs T. Multivariate Calibration in Analytical Chemistry. John Wiley & Sons; 2021.
- Perkel JM. Sustainable analytical chemistry: The future of eco-friendly methods. Nat Methods. 2022;19(8):928–31.

Journal of Thin Films, Coating Science Technology & Application
Volume | 12 |
Issue | 02 |
Received | 09/03/2025 |
Accepted | 27/03/2025 |
Published | 15/06/2025 |
Publication Time | 98 Days |