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Snehal Masurkar,
Prakash Ghewari,
Shilpa S. Ruikar,
- Associate Professor, Krishna Institute of Science and Technology, Krishna Vishwa Vidyapeeth “Deemed to be University”, Taluka-Karad, Dist-Satara, Maharashtra, India
- Professor of Practice, Krishna Institute of Science and Technology, Krishna Vishwa Vidyapeeth “Deemed to be University”, Taluka-Karad, Dist-Satara, Maharashtra, India
- Assistant Professor, Krishna Institute of Science and Technology, Krishna Vishwa Vidyapeeth “Deemed to be University”, Taluka-Karad, Dist-Satara, Maharashtra, India
Abstract
High-performance polymer composites are emerging as versatile platforms for next-generation biomedical sensor interfaces because they can combine mechanical compliance, electrical functionality, biocompatibility, and structural tunability within a single material system. However, the rapid expansion of polymer matrices, conductive nanofillers, hydrogels, and biodegradable materials has produced a highly diverse literature, making it difficult to identify how material composition and interfacial structure determine sensor performance and clinical suitability. This review critically examines high-performance polymer composites for biomedical sensing by linking polymer matrix selection, functional fillers, interfacial interactions, microstructural features, fabrication strategies, and sensing mechanisms with key performance requirements. Particular emphasis is placed on the trade-offs among electrical conductivity, sensitivity, mechanical flexibility, durability, biofouling resistance, biodegradability, and long-term biosafety. Conductive polymer composites, graphene-, carbon nanotube-, MXene-, metal oxide-, hydrogel-, and biodegradable polymer-based systems are comparatively discussed across wearable, implantable, electrochemical, pressure, tactile, and neural sensing applications. Beyond summarizing reported materials, the review identifies application-dependent material requirements, limitations in current composite designs, and barriers associated with reproducibility, nanofiller safety, scalable manufacturing, and clinical translation. An integrated structure–property–performance perspective is proposed to guide rational selection and engineering of polymer composites for specific biomedical sensing environments. Finally, emerging directions involving self-healing materials, multifunctional interfaces, wireless integration, and intelligent sensing are discussed as potential pathways toward clinically translatable and personalized biomedical sensor technologies.
Keywords: Polymer composites; Biomedical sensors; Flexible electronics; Conductive nanocomposites; MXenes; Graphene; Wearable sensors; Implantable interfaces; Structure–property relationships; Clinical translation.
References
1. Wang Y, Gao Y, Tang L, Guo Y, Sha B, Jiang Y. Hydrogel-based wearable and implantable biosensors in health monitoring. Biomater Sci. 2026;14(9):2260-2289. doi:10.1039/D5BM01789K.
2. Preetam S, Nahak BK, Patra S, Toncu DC, Park S, Syväjärvi M, et al. Emergence of microfluidics for next generation biomedical devices. Biosens Bioelectron X. 2022;10:100106. doi:10.1016/j.biosx.2022.100106.
3. Zhang T, Liu N, Xu J, Liu Z, Zhou Y, Yang Y, et al. Flexible electronics for cardiovascular healthcare monitoring. Innovation (Camb). 2023;4(5):100485. doi:10.1016/j.xinn.2023.100485.
4. Gogotsi Y, Anasori B. The rise of MXenes. In: Gogotsi Y, Anasori B, editors. MXenes. Singapore: Jenny Stanford Publishing; 2023. p. 3-11.
5. Lv K, Tian G, Yan Y, Zhou H, Fan Q, Liang L, et al. Stretchable carbon nanotube/Ecoflex conductive elastomer films toward multifunctional wearable electronics. Chem Eng J. 2024;500:157534. doi:10.1016/j.cej.2024.157534.
6. Díez-Pascual AM, Rahdar A. Graphene-based polymer composites for flexible electronic applications. Micromachines (Basel). 2022;13(7):1123. doi:10.3390/mi13071123.
7. Singh A, Ahmed A, Sharma A, Arya S. Graphene and its derivatives: synthesis and application in the electrochemical detection of analytes in sweat. Biosensors (Basel). 2022;12(10):910. doi:10.3390/bios12100910.
8. George JM, Antony A, Mathew B. Metal oxide nanoparticles in electrochemical sensing and biosensing: a review. Microchim Acta. 2018;185(7):358. doi:10.1007/s00604-018-2894-3.
9. Ahmed K, Hassan MM, Kabir MA. Polymer and ceramic nanotechnology for biomedical applications. In: Hussain CM, Thomas S, editors. Handbook of Polymer and Ceramic Nanotechnology. Cham: Springer; 2021. p. 1-20.
10. Lee DH, Park T, Yoo H. Biodegradable polymer composites for electrophysiological signal sensing. Polymers (Basel). 2022;14(14):2875. doi:10.3390/polym14142875.
11. Tan P, Wang H, Xiao F, Lu X, Shang W, Deng X, et al. Solution-processable, soft, self-adhesive, and conductive polymer composites for soft electronics. Nat Commun. 2022;13:358. doi:10.1038/s41467-022-28027-y.
12. Demir D, Bolgen N, Vaseashta A. Electrospun nanofibers for biomedical, sensing, and energy harvesting functions. Polymers (Basel). 2023;15(21):4253. doi:10.3390/polym15214253.
13. Yang H, Fang H, Wang C, Wang Y, Qi C, Zhang Y, et al. 3D printing of customized functional devices for smart biomedical systems. SmartMat. 2024;5(5). doi:10.1002/smm2.1244.
14. Zhao L, Liu Z, Chen D, Liu F, Yang Z, Li X, et al. Laser synthesis and microfabrication of micro/nanostructured materials toward energy conversion and storage. Nano-Micro Lett. 2021;13:49. doi:10.1007/s40820-020-00577-0.
15. Lin JC, Liatsis P, Alexandridis P. Flexible and stretchable electrically conductive polymer materials for physical sensing applications. Polym Rev. 2023;63(1):67-126. doi:10.1080/15583724.2022.2059673.
16. Manibalan K, Chen JT. Recent progress on MXene-polymer composites for soft electronics applications in sensing and biosensing: a review. J Mater Chem A. 2024;12:27130-27156. doi:10.1039/D4TA04211E.
17. Xu J, Lee H. Anti-biofouling strategies for long-term continuous use of implantable biosensors. Chemosensors. 2020;8(3):66. doi:10.3390/chemosensors8030066.
18. Chen J, Zhu Y, Huang J, Zhang J, Pan D, Zhou J, et al. Advances in responsively conductive polymer composites and sensing applications. Polym Rev. 2021;61(1):157-193. doi:10.1080/15583724.2020.1734818.
19. He Y, Wu D, Zhou M, Zheng Y, Wang T, Lu C, et al. Wearable strain sensors based on a porous polydimethylsiloxane hybrid with carbon nanotubes and graphene. ACS Appl Mater Interfaces. 2021;13(13):15572-15583. doi:10.1021/acsami.0c22823.
20. Luo J, Sun C, Chang B, Jing Y, Li K, Li Y, et al. MXene-enabled self-adaptive hydrogel interface for active electroencephalogram interactions. ACS Nano. 2022;16(11):19373-19384. doi:10.1021/acsnano.2c08961.
21. Kannan P, Maduraiveeran G. Carbon nanocomposites-based electrochemical sensors and biosensors for biomedical diagnostics. Curr Med Chem. 2024;31(25):3870-3881. doi:10.2174/0929867330666230425163520.
22. Sun X, Yao F, Li J. Nanocomposite hydrogel-based strain and pressure sensors: a review. J Mater Chem A. 2020;8(36):18605-18623. doi:10.1039/D0TA06965E.
23. Castagnola E, Zheng XS, Cui XT. Flexible and soft materials and devices for neural interface. In: Handbook of Neuroengineering. Singapore: Springer; 2021. p. 79-139.
24. Bhattacharjee M, Sai RM, Chakraborty G, Paul AK. Degradation and toxicological studies of polymeric nanocomposites. In: Resorbable Polymers for Bioimplants and Fixation Devices. Singapore: Springer Nature; 2025. p. 283-314.
25. Sharma PK, Chen CY. AI-integrated micro/nanorobots for biomedical applications: recent advances in design, fabrication, and functions. Biosensors (Basel). 2025;15(12):793. doi:10.3390/bios15120793.

Journal of Polymer & Composites
| Volume | 14 | |
| 05 | ||
| Received | 20/07/2026 | |
| Accepted | 13/08/2026 | |
| Published | 07/10/2026 | |
| Publication Time | 79 Days |
