Prajkta S. Sarkale,
Shubhangi A. Patil,
Sachin Subhash Pawar,
- Assistant Professor, Department of pharmaceutics, Krishna Institute of Science and Technology, Krishna Vishwa Vidyapeeth (Deemed to be University), Taluka-Karad, District-Satara, Maharashtra, India
- Principal, Department of Pharmaceutical Sciences, KCT’s Krishna College of Pharmacy, Karad, Maharashtra, India
- Assistant Professor, Department of Surgery, Krishna Institute of Medical Sciences, KVV, Karad, Satara, Maharashtra, India
Abstract
Cardiovascular diseases are still one of the leading health complications in the world, and coronary artery disease remains one of the toughest ones to crack. The introduction of stent implantation in interventional cardiology is a breakthrough concept which helps to restore blood flow and maintain patency of the arteries. On the other hand, long-term results of bare-metal stents and drug-eluting stents indicate the presence of complications, such as in-stent restenosis, late thrombosis, and chronic inflammation, which are hardly negligible. Recent biodegradable stents alleviate such concerns, providing temporary mechanical support in the vascular system, before degrading into biocompatible byproducts and hence, reducing the long-term complications associated with permanent implants. As opposed to metallic materials which are associated with inflammatory responses, polymeric composites can be custom-designed with specific values on a spectrum of structural strength and bifunctionality. Recent bioresorbable polymers – such as poly-L-lactic acid, polycaprolactone, and their composites with natural polymers or nanoparticles – exhibit improved mechanical integrity and hemocompatibility This review article is dedicated to the history of polymeric stents, which focuses on intricate cardiovascular system applications. It highlights the issues of fabricating materials and methods of degradation, the clinical advancements, and the focus on the difficulties on applying these technologies in everyday clinics. The review provides an outlook on future of next generation stents incorporating smart materials, improved design, nanotechnology, and patient-centered approaches for seamless clinical outcomes in cardiovascular healing.
Keywords: Biodegradable stents, polymeric composites, cardiovascular applications, bioresorbable polymers, coronary artery disease, drug delivery, vascular healing, nanocomposites, tissue compatibility, interventional cardiology.
[This article belongs to Special Issue under section in Journal of Polymer & Composites (jopc)]
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Journal of Polymer & Composites
| Volume | 14 | |
| Special Issue | 04 | |
| Received | 20/07/2026 | |
| Accepted | 04/08/2026 | |
| Published | 19/08/2026 | |
| Publication Time | 30 Days |