Recent Advancements in Nanobiocomposite-Based Wound Healing and Tissue Regeneration

Year : 2026 | Volume : 14 | Issue : 03 | Page : 297 318
    By

    C. Hazarathaiah Yadav,

  • Lavanya D,

  • A. Mohamed Sikkander,

  • M. Mohamed Ismail,

  1. Professor & Head, Department of Chemistry, Vel Tech Rangarajan Dr. Sakunthala R&D Institute of science &Technology, Avadi, Chennai, Tamil Nadu, India
  2. Research Scholar, Department of Chemistry, Vel Tech Rangarajan Dr. Sakunthala R&D Institute of science &Technology, Avadi, Chennai, Tamil Nadu, India
  3. Professor, Department of Chemistry, GKM College of Engineering and Technology, Chennai, Tamil Nadu, India
  4. Research Scholar, Department of Chemistry, Kanda swami Kandar’s College (Affiliated to Periyar University, Salem), P. Velur, Namakkal Dt, Tamil Nadu, India

Abstract

Haemostasis, inflammation, proliferation, remodeling, and other highly coordinated cellular and molecular activities are all part of the complex biological processes of wound healing and tissue regeneration. Following an injury, these stages cooperate to restore tissue integrity and function. However, this normal process is disturbed in many clinical circumstances, especially chronic wounds such diabetic ulcers, burns, and pressure sores. Prolonged inflammation, chronic microbial infection, diminished angiogenesis, and impaired extracellular matrix production are common characteristics of these wounds, which can cause delayed or incomplete healing and place a heavy strain on healthcare systems across the globe. Nanobiocomposites have become a very promising material for improved wound care applications in recent years.

Natural or artificial polymers are combined with nanoscale elements including nanoparticles, nanofibers, and nanotubes to create these hybrid systems. Multifunctional materials with increased qualities, such as potent antibacterial activity, enhanced biocompatibility, regulated medication release, and higher mechanical strength, are the outcome of this integration. Crucially, nanobiocomposites have the ability to precisely resemble the extracellular matrix’s structure and function, which encourages cell adhesion, proliferation, and differentiation all of which are critical for successful tissue regeneration. Innovative platforms like electro spun nanofibers, hydrogels filled with nanoparticles, bioactive scaffolds, and stimuli-responsive smart materials have been the focus of recent developments in this area.

Through the acceleration of angiogenesis, modulation of inflammatory responses, stimulation of collagen synthesis, and prevention of infections, these systems greatly improve wound healing. Therapeutic efficacy has also been enhanced by the addition of bioactive substances, such as growth factors, exosomes generated from stem cells, and chemicals derived from plants. Clinical translation is nevertheless hampered by issues such possible toxicity, large-scale production, regulatory limitations, and long-term safety concerns, despite these positive advancements.

Keywords: Wound healing, tissue regeneration, hydrogels, nanofibers, nanoparticles, smart materials, nanobiocomposites, regenerative medicine

[This article belongs to Journal of Polymer & Composites ]

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How to cite this article:
C. Hazarathaiah Yadav, Lavanya D, A. Mohamed Sikkander, M. Mohamed Ismail. Recent Advancements in Nanobiocomposite-Based Wound Healing and Tissue Regeneration. Journal of Polymer & Composites. 2026; 14(03):297-318.
How to cite this URL:
C. Hazarathaiah Yadav, Lavanya D, A. Mohamed Sikkander, M. Mohamed Ismail. Recent Advancements in Nanobiocomposite-Based Wound Healing and Tissue Regeneration. Journal of Polymer & Composites. 2026; 14(03):297-318. Available from: https://journals.stmjournals.com/jopc/article=2026/view=243817


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Regular Issue Subscription Original Research
Volume 14
Issue 03
Received 07/04/2026
Accepted 23/04/2026
Published 14/05/2026
Publication Time 37 Days
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