Advances in Nanocellulose-Enhanced Polymers and Composites: Structure, Performance, and Applications

Year : 2026 | Volume : 14 | Special Issue 01 | Page : 1610 1623
    By

    Prasanthi Samathoti,

  • Sindhu Chenna,

  • Bhavani Mudamala,

  • Kalyani Chambeti,

  • Shweta Chandra,

  • Harish chakka,

  • Reddy Subramanya Busineni,

  • B. Anushna,

  1. Associate Professor, Department of pharmaceutics, Mohan Babu School of Pharmaceutical Science (Erstwhile Sree vidyanikethan College of Pharmacy), Mohan Babu University, Tirupati, Andhra Pradesh, India
  2. Student, Department of pharmaceutics, Mohan Babu School of Pharmaceutical Science (Erstwhile Sree vidyanikethan College of Pharmacy), Mohan Babu University, Tirupati, Andhra Pradesh, India
  3. Student, Department of pharmaceutics, Mohan Babu School of Pharmaceutical Science (Erstwhile Sree vidyanikethan College of Pharmacy), Mohan Babu University, Tirupati, Andhra Pradesh, India
  4. Student, Department of pharmaceutics, Mohan Babu School of Pharmaceutical Science (Erstwhile Sree vidyanikethan College of Pharmacy), Mohan Babu University, Tirupati, Andhra Pradesh, India
  5. Student, Department of pharmaceutics, Mohan Babu School of Pharmaceutical Science (Erstwhile Sree vidyanikethan College of Pharmacy), Mohan Babu University, Tirupati, Andhra Pradesh, India
  6. Student, Department of pharmaceutics, Mohan Babu School of Pharmaceutical Science (Erstwhile Sree vidyanikethan College of Pharmacy), Mohan Babu University, Tirupati, Andhra Pradesh, India
  7. Student, Department of pharmaceutics, Mohan Babu School of Pharmaceutical Science (Erstwhile Sree vidyanikethan College of Pharmacy), Mohan Babu University, Tirupati, Andhra Pradesh, India
  8. Student, Department of pharmaceutics, Mohan Babu School of Pharmaceutical Science (Erstwhile Sree vidyanikethan College of Pharmacy), Mohan Babu University, Tirupati, Andhra Pradesh, India

Abstract

The most common biopolymer is cellulose, which can be converted into nanocellulose (NC) the sustainable nanomaterial possessing the outstanding characteristic of biodegradability, renewability, low density, high aspect ratio, and excellent mechanical performance. Such distinctive features make NC a promising filler in polymer and composite systems. Recent developments in the preparation of nanocellulose using various natural and artificial sources have facilitated scalable production processes that have less energy requirements and are cost effective. The focus in this review is given on practical preparation methods of nanocellulose and how they affect structure property relationships when incorporated into polymer matrices. Several characterization methods, such as rheological behaviour, powder flow properties, and thermal analyses are presented in order to demonstrate their use in the evaluation of NC-based composites. Special attention is paid to the multifunctional use of polymer nanocellulose composites in the field of structural materials, barrier films, biomedical scaffolds, drug delivery systems, aerogels, wound healing, biosensing, and bioimaging. Comparing nanocellulose to neat polymers, representative studies demonstrate that it can improve biodegradation rates, decrease oxygen permeability by up to 80 times, and increase tensile strength by 20–300%. The extended applicability of nanocellulose shows the possibility of using the material as a sustainable reinforcement of the next generation, high-performance, and environmentally friendly polymer composites.

Keywords: Nanocellulose, Preparation methods, Characterization of nanocellulose, Applications Chemical treatment of cellulose, Acid hydrolysis .

[This article belongs to Special Issue under section in Journal of Polymer & Composites (jopc)]

How to cite this article:
Prasanthi Samathoti, Sindhu Chenna, Bhavani Mudamala, Kalyani Chambeti, Shweta Chandra, Harish chakka, Reddy Subramanya Busineni, B. Anushna. Advances in Nanocellulose-Enhanced Polymers and Composites: Structure, Performance, and Applications. Journal of Polymer & Composites. 2026; 14(01):1610-1623.
How to cite this URL:
Prasanthi Samathoti, Sindhu Chenna, Bhavani Mudamala, Kalyani Chambeti, Shweta Chandra, Harish chakka, Reddy Subramanya Busineni, B. Anushna. Advances in Nanocellulose-Enhanced Polymers and Composites: Structure, Performance, and Applications. Journal of Polymer & Composites. 2026; 14(01):1610-1623. Available from: https://journals.stmjournals.com/jopc/article=2026/view=238089


References

  1. Raghav N, Sharma MR, Kennedy JF. Nanocellulose: A mini-review on types and use in drug delivery systems. Carbohydr Polym Technol Appl. 2021;2:100031. https://doi.org/10.1016/j.carpta.2020.100031
  2. Mateo S, Peinado S, Morillas-Gutiérrez F, et al. Nanocellulose from agricultural wastes: products and applications a review. Processes. 2021;9(9):1594. https://doi.org/10.3390/pr9091594
  3. Varghese RT, Cherian RM, Chirayil CJ, et al. Nanocellulose as an avenue for drug delivery applications: a mini-review. J Compos Sci. 2023;7(6):210. https://doi.org/10.3390/jcs7060210
  4. Seddiqi H, Oliaei E, Honarkar H, et al. Cellulose and its derivatives: towards biomedical applications. Cellulose. 2021;28(4):1893-931.
  5. Jonoobi M, Mathew AP, Oksman K. Recent trends in nanocellulose-based polymer composites: Processing, properties, and applications. J Macromol Sci A Pure Appl Chem. 2022;59(11):698–713. doi:10.1080/15440478.2022.2123076
  6. Phanthong P, Reubroycharoen P, Hao X, Xu G. Nanocellulose-based composites: Preparation, properties, and applications. In: Thakur VK, Thakur MK, editors. Nanocellulose and Nanocarbons Composites: Fundamentals and Applications. Elsevier; 2022. p. 161–189. doi:10.1016/B978-0-12-824528-6.00007-2
  7. Li J, Wang X, Zhou L, Zhang Q. Functional nanocellulose-based polymer composites: Progress and challenges. J Polym Environ. 2024;32:3983–4001. doi:10.1007/s10965-024-03946-0
  8. Saba N, Paridah MT, Jawaid M. Recent advances in nanocellulose-based polymer nanocomposites. J Compos Sci. 2023;7(4):136. doi:10.3390/jcs7040136.
  9. Araki J, Wada M, Kuga S. Steric stabilization of a cellulose microcrystal suspension by poly(ethylene glycol) grafting. Langmuir. 2001;17(1):21-7.
  10. Camarero Espinosa S, Kuhnt T, et al.. Isolation of thermally stable cellulose nanocrystals by phosphoric acid hydrolysis. Biomacromolecules. 2013;14(4):1223-30.
  11. Capadona JR, Van Den Berg O, Capadona LA, et al. A versatile approach for the processing of polymer nanocomposites with self-assembled nanofibre templates. Nat Nanotechnol. 2007;2(12):765-9.
  12. Dong XM, Revol JF, Gray DG. Effect of microcrystallite preparation conditions on the formation of colloid crystals of cellulose. Cellulose. 1998;5:19-32. https://doi.org/10.1023/A:1009260511939
  13. Filson PB, Dawson-Andoh BE, Schwegler-Berry D. Enzymatic-mediated production of cellulose nanocrystals from recycled pulp. Green Chem. 2009;11(11):1808-14. https://doi.org/10.1039/B915746H
  14. Siró I, Plackett D. Microfibrillated cellulose and new nanocomposite materials: a review. Cellulose. 2010;17:459-94. https://doi.org/10.1007/s10570-010-9405-y
  15. Iwamoto S, Kai W, Isogai A, et al. Elastic modulus of single cellulose microfibrils from tunicate measured by atomic force microscopy. Biomacromolecules. 2009;10(9):2571-6.
  16. Klemm D, Kramer F, Moritz S, et al. Nanocelluloses: a new family of nature-based materials. Angew Chem Int Ed. 2011;50(24):5438-66. https://doi.org/10.1002/anie.201001273
  17. Das S, Ghosh B, Sarkar K. Nanocellulose as sustainable biomaterials for drug delivery. Sensors Int. 2022;3:100135. https://doi.org/10.1016/j.sintl.2021.100135
  18. Wang J, Tavakoli J, Tang Y. Bacterial cellulose production, properties and applications with different culture methods a review. Carbohydr Polym. 2019;219:63-76. https://doi.org/10.1016/j.carbpol.2019.05.008
  19. Iguchi M, Yamanaka S, Budhiono A. Bacterial cellulose a masterpiece of nature’s arts. J Mater Sci. 2000;35(2):261-70. https://doi.org/10.1023/A:1004775229149
  20. Nasir M, Hashim R, Sulaiman O, et al. Nanocellulose: preparation methods and applications. In: Cellulose-reinforced nanofibre composites. Woodhead Publishing; 2017. p. 261-76. https://doi.org/10.1016/B978-0-08-100957-4.00011-5
  21. Zhou Z, Li Y, Zhou W. The progress of nanocellulose in types and preparation methods. In: Journal of Physics: Conference Series; 2021 Oct 1; Online. IOP Publishing; 2021. p. 012042. https://doi.org/10.1088/1742-6596/2021/1/012042.
  22. Zuluaga R, Putaux JL, Restrepo A, et al. Cellulose microfibrils from banana farming residues: isolation and characterization. Cellulose. 2007;14:585-92. https://doi.org/10.1007/s10570-007-9118-z
  23. Malainine ME, Mahrouz M, Dufresne A. Thermoplastic nanocomposites based on cellulose microfibrils from Opuntia ficus-indica parenchyma cell. Compos Sci Technol. 2005;65(10):1520-6. https://doi.org/10.1016/j.compscitech.2005.01.003
  24. Panthapulakkal S, Sain MJ. Preparation and characterization of cellulose nanofibril films from wood fibre and their thermoplastic polycarbonate composites. Int J Polym Sci. 2012;2012:381342. https://doi.org/10.1155/2012/381342
  25. Frone AN, Panaitescu DM, Donescu D, et al. Preparation and characterization of PVA composites with cellulose nanofibers obtained by ultrasonication. BioResources. 2011;6(1):487-512.
  26. Johnson RK, Zink-Sharp A, Renneckar SH, et al. A new bio-based nanocomposite: fibrillated TEMPO-oxidized celluloses in hydroxypropylcellulose matrix. Cellulose. 2009;16:227-38. https://doi.org/10.1007/s10570-008-9269-6
  27. Qua EH, Hornsby PR, Sharma HS, et al. Preparation and characterization of poly(vinyl alcohol) nanocomposites made from cellulose nanofibers. J Appl Polym Sci. 2009;113(4):2238-47. https://doi.org/10.1002/app.30116
  28. Ferrer A, Filpponen I, Rodríguez A, et al. Valorization of residual empty palm fruit bunch fibers (EPFBF) by microfluidization: production of nanofibrillated cellulose and EPFBF nanopaper. Bioresour Technol. 2012;125:249-55. https://doi.org/10.1016/j.biortech.2012.08.108
  29. Lee SY, Chun SJ, Doh GH, et al. Influence of chemical modification and filler loading on fundamental properties of bamboo fibers reinforced polypropylene composites. J Compos Mater. 2009;43(15):1639-57. https://doi.org/10.1177/0021998309339352
  30. Keerati-U-Rai M, Corredig M. Effect of dynamic high pressure homogenization on the aggregation state of soy protein. J Agric Food Chem. 2009;57(9):3556-62.
  31. Jonoobi M, Harun J, Mathew AP, et al. Preparation of cellulose nanofibers with hydrophobic surface characteristics. Cellulose. 2010;17:299-307. https://doi.org/10.1007/s10570-009-9387-9
  32. Zhang L, Tsuzuki T, Wang X. Preparation of cellulose nanofiber from softwood pulp by ball milling. Cellulose. 2015;22:1729-41. https://doi.org/10.1007/s10570-015-0582-6
  33. Abramov OV. High-intensity ultrasonics: theory and industrial applications. Boca Raton: CRC Press; 2019. https://doi.org/10.1201/9780203751954
  34. Cheng Q, Wang S, Rials TG. Poly(vinyl alcohol) nanocomposites reinforced with cellulose fibrils isolated by high intensity ultrasonication. Compos Part A Appl Sci Manuf. 2009;40(2):218-24. https://doi.org/10.1016/j.compositesa.2008.11.009
  35. Pääkkö M, Ankerfors M, Kosonen H, et al. Enzymatic hydrolysis combined with mechanical shearing and high-pressure homogenization for nanoscale cellulose fibrils and strong gels. Biomacromolecules. 2007;8(6):1934-41.
  36. Afrin S, Karim Z. Isolation and surface modification of nanocellulose: necessity of enzymes over chemicals. ChemBioEng Rev. 2017;4(5):289-303. https://doi.org/10.1002/cben.201600001
  37. Shah N, Ul-Islam M, Khattak WA, et al. Overview of bacterial cellulose composites: a multipurpose advanced material. Carbohydr Polym. 2013;98(2):1585-98. https://doi.org/10.1016/j.carbpol.2013.08.018
  38. Robles E, Fernández-Rodríguez J, Barbosa AM, et al. Production of cellulose nanoparticles from blue agave waste treated with environmentally friendly processes. Carbohydr Polym. 2018;183:294-302. https://doi.org/10.1016/j.carbpol.2018.01.015
  39. Ching YC, Ershad Ali M, Abdullah LC, et al. Rheological properties of cellulose nanocrystal-embedded polymer composites: a review. Cellulose. 2016;23:1011-30. https://doi.org/10.1007/s10570-016-0868-3
  40. Pinkert A, Marsh KN, Pang S, et al. Ionic liquids and their interaction with cellulose. Chem Rev. 2009;109(12):6712-28.
  41. Abraham E, Kam D, Nevo Y, et al. Highly modified cellulose nanocrystals and formation of epoxy-nanocrystalline cellulose (CNC) nanocomposites. ACS Appl Mater Interfaces. 2016;8(41):28086-95.
  42. Yang J, Han C. Mechanically viscoelastic properties of cellulose nanocrystals skeleton reinforced hierarchical composite hydrogels. ACS Appl Mater Interfaces. 2016;8(38):25621-30.
  43. Ekka NR, Namdeo KP, Samal PK. Standardization strategies for herbal drugs an overview. Res J Pharm Technol. 2008;1(4):310-2.
  44. O’Brien FE. The control of humidity by saturated salt solutions. J Sci Instrum. 1948;25(3):73. https://doi.org/10.1088/0950-7671/25/3/305
  45. Vilela C, Morais JD, Silva AC, et al. Flexible nanocellulose/lignosulfonates ion-conducting separators for polymer electrolyte fuel cells. Nanomaterials. 2020;10(9):1713. https://doi.org/10.3390/nano10091713
  46. Liu K. New and improved methods for measuring acid insoluble ash. Anim Feed Sci Technol. 2022;288:115282. https://doi.org/10.1016/j.anifeedsci.2022.115282
  47. Al-Hashemi HM, Al-Amoudi OS. A review on the angle of repose of granular materials. Powder Technol. 2018;330:397-417. https://doi.org/10.1016/j.powtec.2018.02.003
  48. Segal LG, Creely JJ, Martin AE Jr, et al. An empirical method for estimating the degree of crystallinity of native cellulose using the X-ray diffractometer. Text Res J. 1959;29(10):786-94. https://doi.org/10.1177/004051755902901003
  49. Hossain S. PLA–Nanocellulose Composites: Performance and Biodegradation for Sustainable Packaging.
  50. Talebi H., Ashenai Ghasemi A., Ashori A. Effect of nanocellulose on mechanical and physical properties of chitosan-based biocomposites. Appl. Polym. Sci. 2022;139(21):e51964.
  51. Zailuddin N.F. Morphology, mechanical properties, and biodegradability of all-cellulose composite films from oil palm empty fruit bunch. Eng. Sci. 2020;60(10):2808–2819.
  52. Torres F.G., et al. High-Barrier and Antioxidant Poly(lactic acid)/Nanocellulose Multilayered Materials for Packaging. Polymers 2020;12(9):2017.
  53. Aulin C., et al. High strength, flexible and transparent nanofibrillated cellulose–nanoclay biohybrid films. Nanoscale 2012;4(20):6622–6628.
  54. Tanjung F.A., et al. Biodegradation behaviour of nanocellulose-based films for food packaging applications. J. Biol. Macromol 2024;260:129246
  55. Hubbe MA, Ferrer A, Tyagi P, Yin Y, Salas C, Pal L, et al. Nanocellulose in thin films, coatings, and plies for packaging applications: A review. BioResources. 2017;12(1):2143–2233
  56. Mariano M, El Kissi N, Dufresne A. Cellulose nanocrystals and related nanocomposites: Review of some properties and challenges. Carbohydr Polym. 2014;117:802–809
  57. Abdul Khalil HPS, Davoudpour Y, Islam MN, Mustapha A, Sudesh K, Dungani R, et al. Production and modification of nanofibrillated cellulose using various mechanical processes: A review. Materials (Basel). 2021;14(19):6312.
  58. Trache D, Tarchoun AF, Derradji M, et al. Nanocellulose: from fundamentals to advanced applications. Front Chem. 2020;8:392. https://doi.org/10.3389/fchem.2020.00392
  59. Lin N, Dufresne A. Nanocellulose in biomedicine: current status and future prospect. Eur Polym J. 2014;59:302-25. https://doi.org/10.1016/j.eurpolymj.2014.07.025
  60. Trache D. Nanocellulose as a promising sustainable material for biomedical applications. AIMS Mater Sci. 2018;5(2):201-5.
  61. Bacakova L, Pajorova J, Bacakova M, et al. Versatile application of nanocellulose: from industry to skin tissue engineering and wound healing. Nanomaterials. 2019;9(2):164. https://doi.org/10.3390/nano9020164
  62. Karimian A, Parsian H, Majidinia M, et al. Nanocrystalline cellulose: preparation, physicochemical properties, and applications in drug delivery systems. Int J Biol Macromol. 2019;133:850-9. https://doi.org/10.1016/j.ijbiomac.2019.04.117
  63. Moohan J, Stewart SA, Espinosa E, et al. Cellulose nanofibers and other biopolymers for biomedical applications: a review. Appl Sci. 2019;10(1):65. https://doi.org/10.3390/app10010065
  64. George J, Sabapathi SN. Cellulose nanocrystals: synthesis, functional properties, and applications. Nanotechnol Sci Appl. 2015;8:45-54.
  65. Grishkewich N, Mohammed N, Tang J, et al. Recent advances in the application of cellulose nanocrystals. Curr Opin Colloid Interface Sci. 2017;29:32-45. https://doi.org/10.1016/j.cocis.
    01.005
  66. Ilyas RA, Sapuan SM, Sanyang ML, et al. Nanocrystalline cellulose as reinforcement for polymeric matrix nanocomposites and its potential applications: a review. Curr Anal Chem. 2018;14(3):203-25. https://doi.org/10.2174/1573411013666171003155624
  67. Shaheen TI, Montaser AS, Li S. Effect of cellulose nanocrystals on scaffolds comprising chitosan, alginate and hydroxyapatite for bone tissue engineering. Int J Biol Macromol. 2019;121:814-21. https://doi.org/10.1016/j.ijbiomac.2018.10.081
  68. Mogoşanu GD, Grumezescu AM. Natural and synthetic polymers for wounds and burns dressing. Int J Pharm. 2014;463(2):127-36. https://doi.org/10.1016/j.ijpharm.2013.12.015
  69. Hamedi H, Moradi S, Hudson SM, et al. Chitosan based hydrogels and their applications for drug delivery in wound dressings: a review. Carbohydr Polym. 2018;199:445-60. https://doi.org/10.1016/j.carbpol.2018.06.114
  70. Kolakovic R, Peltonen L, Laukkanen A, et al. Nanofibrillar cellulose films for controlled drug delivery. Eur J Pharm Biopharm. 2012;82(2):308-15. https://doi.org/10.1016/j.ejpb.2012.06.011
  71. Jackson JK, Letchford K, Wasserman BZ, et al. The use of nanocrystalline cellulose for the binding and controlled release of drugs. Int J Nanomedicine. 2011;6:321-30.
  72. Burt HM, Jackson JK, Hamad WY. U.S. Patent Application No. 13/885,503. 2014.
  73. Guo T, Pei Y, Tang K, et al. Mechanical and drug release properties of alginate beads reinforced with cellulose. J Appl Polym Sci. 2017;134(8):1-8. https://doi.org/10.1002/app.44495
  74. Fu L, Zhang J, Yang G. Present status and applications of bacterial cellulose-based materials for skin tissue repair. Carbohydr Polym. 2013;92(2):1432-42. https://doi.org/10.1016/j.carbpol.
    10.071
  75. Silva NH, Rodrigues AF, Almeida IF, et al. Bacterial cellulose membranes as transdermal delivery systems for diclofenac: in vitro dissolution and permeation studies. Carbohydr Polym. 2014;106:264-https://doi.org/10.1016/j.carbpol.2014.02.014
  76. Laurén P, Paukkonen H, Lipiäinen T, et al. Pectin and mucin enhance the bioadhesion of drug loaded nanofibrillated cellulose films. Pharm Res. 2018;35:1-4. https://doi.org/10.1007/s11095-018-2428-z
  77. Czaja WK, Young DJ, Kawecki M, et al. The future prospects of microbial cellulose in biomedical applications. Biomacromolecules. 2007;8(1):1-2.
  78. Moniri M, Boroumand Moghaddam A, Azizi S, et al. Production and status of bacterial cellulose in biomedical engineering. Nanomaterials. 2017;7(9):257. https://doi.org/10.3390/nano7090257
  79. Oprea M, Panaitescu DM. Nanocellulose hybrids with metal oxides nanoparticles for biomedical applications. Molecules. 2020;25(18):4045. https://doi.org/10.3390/molecules25184045
  80. Klemm D, Petzold-Welcke K, Kramer F, et al. Biotech nanocellulose: a review on progress in product design and today’s state of technical and medical applications. Carbohydr Polym. 2021;254:117313. https://doi.org/10.1016/j.carbpol.2020.117313
  81. Ludwicka K, Jedrzejczak-Krzepkowska M, Kubiak K, et al. Medical and cosmetic applications of bacterial nanocellulose. In: Bacterial Nanocellulose. Amsterdam: Elsevier; 2016. p. 145–65.
  82. Souza AG, Ferreira RR, Aguilar ES, et al. Cinnamon essential oil nanocellulose-based Pickering emulsions: processing parameters effect on their formation, stabilization, and antimicrobial activity. Polysaccharides. 2021;2(3):608-25. https://doi.org/10.3390/polysaccharides2030037
  83. Bhandari J, Mishra H, Mishra PK, et al. Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery. Int J Nanomedicine. 2017;12:2021-31.
  84. Huo Y, Liu Y, Xia M, et al. Nanocellulose-based composite materials used in drug delivery systems. Polymers. 2022;14(13):2648. https://doi.org/10.3390/polym14132648
  85. Cherian BM, Leão AL, de Souza SF, et al. Bacterial nanocellulose for medical implants. In: Advances in Natural Polymers: Composites and Nanocomposites. 2013. p. 337–59. https://doi.org/10.1007/978-3-642-20940-6_10
  86. Emara L, El-Ashmawy A, Taha N, et al. Freeze-dried nanocrystalline cellulose derived from water sugar-cane bagasse as a novel tablet excipient. In: 41st Annual Meeting & Exposition of the Controlled Release Society; 2014; Chicago, IL, USA. p. 13-16.
  87. Dong H, Snyder JF, Tran DT, et al. Hydrogel, aerogel and film of cellulose nanofibrils functionalized with silver nanoparticles. Carbohydr Polym. 2013;95(2):760-7. https://doi.org/10.1016/j.carbpol.2013.03.041
  88. Yang X, Bakaic E, Hoare T, et al. Injectable polysaccharide hydrogels reinforced with cellulose nanocrystals: morphology, rheology, degradation, and cytotoxicity. Biomacromolecules. 2013;14(12):4447-55.
  89. Jagur-Grodzinski J. Polymeric gels and hydrogels for biomedical and pharmaceutical applications. Polym Adv Technol. 2010;21(1):27-47. https://doi.org/10.1002/pat.1504
  90. Gama M, Gatenholm P, Klemm D, editors. Bacterial nanocellulose: a sophisticated multifunctional material. CRC Press; 2012 Nov 13.

Special Issue Subscription Review Article
Volume 14
Special Issue 01
Received 19/09/2025
Accepted 22/10/2025
Published 10/03/2026
Publication Time 172 Days


Login


My IP

PlumX Metrics