Comparative Study on Oro Dispersible Tablets of Candesartan Cilexetil Formulated with Natural and Synthetic Disintegrants

Year : 2026 | Volume : 14 | Special Issue 01 | Page : 687 695
    By

    G. Uma Rani,

  • K. Aswini,

  1. Professor, Department of Pharmaceutics, RBVRR Women’s College of Pharmacy, Hyderabad, Telangana, India
  2. Student, Department of Pharmaceutics, RBVRR Women’s College of Pharmacy, Hyderabad, Telangana, India

Abstract

Candesartan cilexetil, a BCS class II drug with low aqueous solubility and poor bioavailability (15%), poses challenges for oral delivery. To address this limitation, the present study focuses on polymer-based inclusion complexation and composite formulation strategies to enhance solubility and dissolution behavior. The drug was incorporated into β-cyclodextrin (β-CD), a cyclic oligosaccharide polymer, by the kneading method in different drug-to-carrier ratios. Among these, the 1:1 molar ratio complex exhibited the most significant solubility enhancement, demonstrating the potential of polymeric host–guest interactions in drug delivery. The β-CD inclusion complex was subsequently incorporated into Oro dispersible tablet (ODT) systems using both natural and synthetic polymeric disintegrants. Natural biopolymers such as banana powder and oat powder were employed alongside synthetic disintegrants including microcrystalline cellulose (MCC) and sodium starch glycolate (SSG). Formulations prepared by direct compression were characterized for their mechanical strength, friability, disintegration efficiency, water absorption, and in vitro dissolution behavior. Optimized formulations containing banana powder (B4) and a banana–oat composite (OB2) demonstrated rapid disintegration (19 s and 26 s, respectively) and significantly improved drug release, achieving 98.7% within 3 min and 97.2% within 5 min. Short-term stability studies confirmed no significant changes in the physicochemical or dissolution properties of the optimized composites. This work highlights the utility of polymeric inclusion complexes and natural–synthetic polymer composites as multifunctional excipients in the design of advanced oral drug delivery systems. The approach underscores the role of polymer science in tailoring solubility, disintegration, and release kinetics of poorly soluble therapeutic agents.

Keywords: Oro dispersible tablet, Candesartan cilexetil, Banana powder, Oat powder, Microcrystalline cellulose (MCC), Sodium Starch Glycolate.

[This article belongs to Special Issue under section in Journal of Polymer & Composites (jopc)]

How to cite this article:
G. Uma Rani, K. Aswini. Comparative Study on Oro Dispersible Tablets of Candesartan Cilexetil Formulated with Natural and Synthetic Disintegrants. Journal of Polymer & Composites. 2026; 14(01):687-695.
How to cite this URL:
G. Uma Rani, K. Aswini. Comparative Study on Oro Dispersible Tablets of Candesartan Cilexetil Formulated with Natural and Synthetic Disintegrants. Journal of Polymer & Composites. 2026; 14(01):687-695. Available from: https://journals.stmjournals.com/jopc/article=2026/view=236075


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Special Issue Subscription Original Research
Volume 14
Special Issue 01
Received 08/11/2025
Accepted 29/12/2025
Published 15/01/2026
Publication Time 68 Days
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