Synthesis of Silver Nanoparticles of Cissus Quandrangularis and It’s Virtual Screening Against Gastric Cancer

Year : 2026 | Volume : 14 | Special Issue 01 | Page : 1551 1569
    By

    A.Sheela Devi,

  • M. Mary Jaculine,

  • R. Josephine Usha,

  • S. Ilayarasan,

  • V. Chithambaram,

  • G. Viju,

  1. Professor, Department of Biotechnology, Karpaga Vinayaga College of Engineering and Technology, Chinna Kolambakkam, Palayanoor Post, Madhuranthagam Taluk, Chengalpattu District, Tamil Nadu, India
  2. Professor, Department of Physics, Loyala–ICAM College of Engineering and Technology, Nungambakkalam, Chennai, Tamil Nadu, India
  3. Assistant Professor, Department of Physics, S.A. Engineering College, Poonamallee, Chennai, Tamil Nadu, India
  4. Professor, Department of Biotechnology, Karpaga Vinayaga College of Engineering and Technology, Chinna Kolambakkam, Palayanoor Post, Madhuranthagam Taluk, Chengalpattu District, Tamil Nadu, India
  5. Professor, Department of Physics, Rajalakshmi Engineering College, Thandalam, Chennai, Tamil Nadu, India
  6. Professor, Department of Physics, Anand Institute of Higher Technology, Chennai, Tamil Nadu, India

Abstract

Gastric cancer, also known as stomach cancer, is the third leading cause of cancer-related deaths globally and remains a major health challenge due to its poor prognosis and high mortality, largely attributed to late-stage diagnosis. In this context, plant-based nanomaterials are gaining momentum for targeted therapeutic applications. Cissus quadrangularis, a medicinal plant native to India from the Vitaceae family, is traditionally used for its diverse healing properties. Its stem, in particular, has demonstrated antimicrobial, antioxidant, antiulcer, and cytoprotective effects, including notable protection of the gastric mucosa and aid in bone fracture recovery. Silver nanoparticles (AgNPs), sized below 100 nm in at least one dimension, have emerged as promising nanomaterials due to their distinctive physical, chemical, and biological properties. In this study, AgNPs were synthesized using an eco-friendly green synthesis approach with Cissus quadrangularis stem extract. The nanoparticles were characterized using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and UV-visible spectroscopy to confirm their crystalline nature, functional groups, and optical properties. The resulting bio-fabricated AgNPs can be considered as part of a bio-organic nanocomposite system, where plant-derived organic molecules act as stabilizing and capping agents for the metallic nanoparticles. This hybrid composite framework reflects key characteristics of polymer-based materials, offering improved biocompatibility and functional integration for biomedical applications. The synthesized AgNPs were subjected to virtual screening to assess their potential anticancer activity against gastric cancer, indicating promising therapeutic relevance within the domain of polymer-supported nanomedicine

Keywords: Cissus quadrangularis, gastric cancer, molecular docking, silver nanoparticles, stomach cancer

[This article belongs to Special Issue under section in Journal of Polymer & Composites (jopc)]

How to cite this article:
A.Sheela Devi, M. Mary Jaculine, R. Josephine Usha, S. Ilayarasan, V. Chithambaram, G. Viju. Synthesis of Silver Nanoparticles of Cissus Quandrangularis and It’s Virtual Screening Against Gastric Cancer. Journal of Polymer & Composites. 2026; 14(01):1551-1569.
How to cite this URL:
A.Sheela Devi, M. Mary Jaculine, R. Josephine Usha, S. Ilayarasan, V. Chithambaram, G. Viju. Synthesis of Silver Nanoparticles of Cissus Quandrangularis and It’s Virtual Screening Against Gastric Cancer. Journal of Polymer & Composites. 2026; 14(01):1551-1569. Available from: https://journals.stmjournals.com/jopc/article=2026/view=229368


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Special Issue Subscription Review Article
Volume 14
Special Issue 01
Received 25/06/2025
Accepted 03/09/2025
Published 31/03/2026
Publication Time 279 Days
222

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