Biodegradable Polymer Nano Composites for Enhanced Drug Bioavailability

Year : 2025 | Volume : 13 | Special Issue 06 | Page : 433 443
    By

    Waghmode R. R.,

  • Vaishali Patil,

  • Mohini Kolhe,

  • Sachin R. Kandharkar,

  1. Assistant Professor, Department of Pharmaceutics, Krishna Vishwa Vidyapeeth (Deemed to be University), Krishna Institute of Pharmacy, Karad, Maharashtra, India
  2. Assistant Professor, Department of Engineering Sciences and Humanities, Vishwakarma Institute of Technology, Pune, Maharshtra, India
  3. Assistant Professor, Department of Mechanical Engineering, Dr. D.Y. Patil Institute of Technology, Pimpri, Pune, Maharshtra, India
  4. Assistant Professor, Department of Mechanical Engineering, MES Wadia College of Engineering, Pune, Maharshtra, India

Abstract

Polymer-based nanoparticles have emerged as a revolutionary approach in drug delivery systems, particularly in enhancing the bioavailability of poorly soluble and unstable drugs. These nanoparticles, composed of both natural and synthetic polymers, serve as effective vehicles for encapsulating a wide range of therapeutic agents. Their surface characteristics can also be modified to enable targeted drug delivery, increasing the concentration of drugs at the site of action while minimizing side effects. In addition, polymer nanoparticles enhance the permeability of drugs through biological barriers, such as the gastrointestinal tract and blood-brain barrier, which are often limiting factors in drug absorption. This paper explores the mechanisms through which polymer-based nanoparticles improve drug bioavailability, with a focus on their ability to enhance solubility, provide sustained drug release, and enable targeted therapy. The types of polymers used, including biodegradable and biocompatible options, are discussed. Despite the promising potential, challenges such as toxicity, manufacturing complexity, and regulatory hurdles remain. The paper concludes with a look at the future prospects of polymer-based nanoparticles in advancing drug delivery and their clinical applications.

Keywords: Drug bioavailability, bioavailability enhancement, targeted drug delivery, nanoparticle encapsulation, controlled drug release.

[This article belongs to Special Issue under section in Journal of Polymer & Composites (jopc)]

How to cite this article:
Waghmode R. R., Vaishali Patil, Mohini Kolhe, Sachin R. Kandharkar. Biodegradable Polymer Nano Composites for Enhanced Drug Bioavailability. Journal of Polymer & Composites. 2025; 13(06):433-443.
How to cite this URL:
Waghmode R. R., Vaishali Patil, Mohini Kolhe, Sachin R. Kandharkar. Biodegradable Polymer Nano Composites for Enhanced Drug Bioavailability. Journal of Polymer & Composites. 2025; 13(06):433-443. Available from: https://journals.stmjournals.com/jopc/article=2025/view=235122


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Special Issue Subscription Original Research
Volume 13
Special Issue 06
Received 12/06/2025
Accepted 24/07/2025
Published 05/09/2025
Publication Time 85 Days
34

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