Biodegradable and Natural Fiber-Reinforced Polymer Composites for Sustainable Biomedical Applications

Year : 2025 | Volume : 13 | Special Issue 06 | Page : 420 432
    By

    Jadhav P.P.,

  • T.B. Bhattacharjee,

  • Ashok Kr. Sharma,

  1. Assistant Professor, Department of Pharmacology, Krishna Vishwa Vidyapeeth (Deemed to be University), Krishna Institute of Pharmacy, Karad, Maharshtra, India
  2. Assistant Professor, Department of Chemical Engineering, Vishwakarma Institute of Technology, Pune, Maharshtra, India
  3. Assistant Professor, Department of Pharmacy, Arya College of Pharmacy, Jaipur, Rajasthan, India

Abstract

Liposomal drug delivery has evolved into a viable approach in modern pharmacology thanks to its enhanced bioavailability, reduced systemic toxicity, and targeted drug release. Conventional liposomes have limited stability, medicine leakage, and short circulation times among other problems. Overcoming these limits, the inclusion of nano-polymers into liposomal formulations has transformed medication delivery. Thorough research has been done on the potential of nano-polymers including chitosan, hyaluronic acid, polyethylene glycol (PEG), and poly(lactic-co-glycolic acid) (PLGA) to boost drug encapsulation efficiency, liposomal stability, and controlled or stimuli-responsive drug release. PLGA, for instance, encourages continuous drug release, while PEGylation blocks immune clearance thereby extending circulatory half-life. Perfect for non-invasive drug delivery systems, liposomes coated with chitosan improve cohesion. Targeted distribution made possible by ligand-functionalized nano-polymers helps to lower off-target effects and improve treatment results in illnesses like cancer and neurological diseases. From a pharmacological sense, nano-polymer-modified liposomes provide improved pharmacokinetics and pharmacodynamics than standard formulations. Despite these benefits, broad clinical usage requires addressing issues such polymer immunogenicity, biodegradability issues, and the high cost of large-scale manufacture. Examined in this article with an eye towards present advancements, pharmacological consequences, and future directions is the mechanistic role of nano-polymers in liposomal drug transport. Furthermore explored is the therapeutic potential of liposomes changed with nano polymers in precision medicine, cancer treatment, and gene therapy. Maximizing liposomal medicine delivery for improved patient outcomes depends on nano-polymers as nanotechnology and polymer chemistry keep developing.

Keywords: Nano-polymers, liposomal drug delivery, pharmacology, controlled release, bioavailability enhancement.

[This article belongs to Special Issue under section in Journal of Polymer & Composites (jopc)]

How to cite this article:
Jadhav P.P., T.B. Bhattacharjee, Ashok Kr. Sharma. Biodegradable and Natural Fiber-Reinforced Polymer Composites for Sustainable Biomedical Applications. Journal of Polymer & Composites. 2025; 13(06):420-432.
How to cite this URL:
Jadhav P.P., T.B. Bhattacharjee, Ashok Kr. Sharma. Biodegradable and Natural Fiber-Reinforced Polymer Composites for Sustainable Biomedical Applications. Journal of Polymer & Composites. 2025; 13(06):420-432. Available from: https://journals.stmjournals.com/jopc/article=2025/view=235079


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Special Issue Subscription Original Research
Volume 13
Special Issue 06
Received 12/06/2025
Accepted 14/07/2025
Published 05/09/2025
Publication Time 85 Days
39

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