Biodegradable and Natural Fiber-Reinforced Polymer Composites for Co-Delivery of Multiple Therapeutic Agents

Year : 2025 | Volume : 13 | Special Issue 06 | Page : 406 419
    By

    Veer M.N.,

  • P.K. Kale,

  • Ram Garg,

  1. Assistant Professor, Department of Pharmaceutical Chemistry, Krishna Vishwa Vidyapeeth (Deemed to be University), Krishna Institute of Pharmacy, Karad, Maharashtra, India
  2. Assistant Professor, Department of Mechanical Engineering, Vishwakarma Institute of Technology, Pune, Maharshtra, India
  3. Assistant Professor, Department of Pharmacy, Arya College of Pharmacy, Jaipur, Rajasthan, India

Abstract

The co-delivery of multiple drugs using advanced nanocarriers has revolutionized targeted therapy in various diseases, particularly in cancer, infectious diseases, and neurological disorders. Multi-layered polymeric nanocarriers (MLPNs) offer a sophisticated platform to encapsulate multiple therapeutic agents with precise control over drug release, bioavailability, and synergistic effects. These nanocarriers are designed with distinct polymer layers that enable sequential or simultaneous drug release based on stimuli-responsive mechanisms such as pH, temperature, and enzymatic activity. Biodegradable polymers, including poly(lactic-co-glycolic acid) (PLGA), chitosan, and polycaprolactone (PCL), are commonly employed due to their excellent biocompatibility and tunable degradation rates. Various fabrication techniques such as layer-by-layer (LbL) assembly, emulsion solvent evaporation, and nanoprecipitation are utilized to construct MLPNs, allowing for the incorporation of both hydrophilic and hydrophobic drugs. These nanocarriers have demonstrated significant potential in overcoming multidrug resistance, improving drug stability, and reducing systemic toxicity. In cancer therapy, MLPNs facilitate the co-delivery of chemotherapeutic agents with gene therapy molecules to enhance treatment efficacy. Similarly, in infectious diseases, these nanocarriers enhance antibiotic performance against drug-resistant pathogens. Despite their advantages, challenges remain in large-scale production, stability, and regulatory approval for clinical applications. Further research is required to optimize polymer compositions, assess long-term biocompatibility, and develop scalable manufacturing processes. This review explores the latest advancements in MLPN technology, their biomedical applications, and the future prospects of these nanocarriers in personalized medicine and targeted drug delivery.

Keywords: Controlled drug release, encapsulation efficiency, targeted drug delivery, pharmacokinetics enhancement, antimicrobial nanocarriers, biodegradable polymers, nanoparticle drug carriers, sustained drug release, nanomedicine, biocompatibility.

[This article belongs to Special Issue under section in Journal of Polymer & Composites (jopc)]

How to cite this article:
Veer M.N., P.K. Kale, Ram Garg. Biodegradable and Natural Fiber-Reinforced Polymer Composites for Co-Delivery of Multiple Therapeutic Agents. Journal of Polymer & Composites. 2025; 13(06):406-419.
How to cite this URL:
Veer M.N., P.K. Kale, Ram Garg. Biodegradable and Natural Fiber-Reinforced Polymer Composites for Co-Delivery of Multiple Therapeutic Agents. Journal of Polymer & Composites. 2025; 13(06):406-419. Available from: https://journals.stmjournals.com/jopc/article=2025/view=234943


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Special Issue Subscription Review Article
Volume 13
Special Issue 06
Received 12/06/2025
Accepted 16/07/2025
Published 05/09/2025
Publication Time 85 Days
32

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