Biodegradable Polymer Nanocarriers Composites for Biomedical Applications

Year : 2025 | Volume : 13 | Special Issue 06 | Page : 293 305
    By

    Kishor Waghulde,

  • Nangare S. N.,

  • G. G. Dongre,

  • Shankar Lal Soni,

  1. Assistant Professor, Department of Mechanical Engineering, Dr. D.Y. Patil Institute of Technology, Pimpri, Pune, Maharshtra, India
  2. Assistant Professor, Department of Pharmaceutics, Krishna Vishwa Vidyapeeth (Deemed to be University), Krishna Institute of Pharmacy, Karad, Maharshtra, India
  3. Assistant Professor, Department of Mechanical Engineering, Vishwakarma Institute of Technology, Pune, Maharshtra, India
  4. Assistant Professor, Department of Pharmacy, Arya College of Pharmacy, Jaipur, Rajasthan, India

Abstract

Smart polymeric nanocarriers, or SPNs, have evolved into a fascinating means of delivering medications especially to cancer cells. By improving the efficacy of chemotherapeutic treatments while lowering their negative effects, they have achieved a significant progress in exact medicine. Made to respond to certain elements in the tumours microenvironment, such as enzymes, temperature, pH, and redox conditions, these nanocarriers this reaction to triggers guarantees the release of the medicine at the appropriate location, therefore improving its accessibility and reducing its systemic toxicity. Add different polymers poly (lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), and dendrimers to SPNs to enable their correct release of medications and maintain stability. By interacting with overexpressed receptors and enhancing selectivity and absorption, adding ligands such as antibodies, peptides, small molecules allows one to target cancer cells. Apart from active targeting, passive targeting may also be accomplished by means of the enhanced permeability and retention (EPR) influence. This is the reason SPNs congregate in tumors leaky blood vessels. Together, passive and active targeting techniques have a synergistic impact that increases the efficacy of treatment even more. In the past few years, advanced nanotechnology methods like surface modification, packaging, and drug-loading optimisation have helped the development of SPNs. These methods make it easier to give many types of anticancer drugs, such as chemotherapy drugs, RNA-based treatments, and immunomodulatory drugs.

Keywords: Smart polymeric nanocarriers, targeted drug delivery, cancer therapy, stimuli-responsive, nanomedicine.

[This article belongs to Special Issue under section in Journal of Polymer & Composites (jopc)]

How to cite this article:
Kishor Waghulde, Nangare S. N., G. G. Dongre, Shankar Lal Soni. Biodegradable Polymer Nanocarriers Composites for Biomedical Applications. Journal of Polymer & Composites. 2025; 13(06):293-305.
How to cite this URL:
Kishor Waghulde, Nangare S. N., G. G. Dongre, Shankar Lal Soni. Biodegradable Polymer Nanocarriers Composites for Biomedical Applications. Journal of Polymer & Composites. 2025; 13(06):293-305. Available from: https://journals.stmjournals.com/jopc/article=2025/view=234080


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Special Issue Subscription Original Research
Volume 13
Special Issue 06
Received 12/06/2025
Accepted 22/07/2025
Published 05/09/2025
Publication Time 85 Days
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