Advances in Polymer Chemistry for Coronary Artery Disease

Year : 2025 | Volume : 13 | Special Issue 06 | Page : 710 716
    By

    Anushka A. Vaidya,

  • Virendra C Patil,

  1. General Medicine Resident, Department of General Medicine, Krishna Institute of Medical Science, Krishna Vishwa Vidyapeeth Deemed to be University, Malkapur, Karad, Maharshtra, India
  2. Professor, Department of General Medicine, Krishna Institute of Medical Science, Krishna Vishwa Vidyapeeth Deemed to be University, Malkapur, Karad, Maharshtra, India

Abstract

Coronary artery disease (CAD) remains the leading cause of morbidity and mortality worldwide, driving ongoing innovation in therapeutic materials and device design. Polymer chemistry has emerged as a cornerstone in the development of advanced cardiovascular interventions, offering versatile platforms to improve the safety, efficacy, and functionality of implantable devices. This review explores recent advances in the synthesis and application of biodegradable and biostable polymers, focusing on their roles in drug-eluting stents (DES), bioresorbable scaffolds, and polymer-based drug delivery systems. Tailored polymer architectures, including block copolymers, smart and stimuli-responsive polymers, and surface-functionalized composites, have enhanced drug release kinetics, reduced thrombogenicity, and improved endothelialization. Advances in polymer molecular design—such as incorporating hydrophilic segments, functional side chains, or bioactive molecules—have further improved biocompatibility and mechanical performance, addressing clinical challenges like in-stent restenosis and late thrombosis. The review also highlights emerging trends, including shape-memory polymers and electroactive composites that respond dynamically to physiological cues. Finally, translational challenges, including biodegradation kinetics, scale-up synthesis, and regulatory considerations, are critically discussed. By integrating polymer chemistry insights with clinical perspectives, this paper underscores the transformative potential of polymer-based biomaterials in reshaping the prevention, diagnosis, and treatment of CAD, ultimately advancing patient care.

Keywords: Coronary artery disease (CAD), polymer chemistry, drug-eluting stents (DES), bioresorbable scaffolds, biodegradable polymers, smart polymers, surface functionalization.

[This article belongs to Special Issue under section in Journal of Polymer & Composites (jopc)]

How to cite this article:
Anushka A. Vaidya, Virendra C Patil. Advances in Polymer Chemistry for Coronary Artery Disease. Journal of Polymer & Composites. 2025; 13(06):710-716.
How to cite this URL:
Anushka A. Vaidya, Virendra C Patil. Advances in Polymer Chemistry for Coronary Artery Disease. Journal of Polymer & Composites. 2025; 13(06):710-716. Available from: https://journals.stmjournals.com/jopc/article=2025/view=227681


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Special Issue Subscription Review Article
Volume 13
Special Issue 06
Received 09/07/2025
Accepted 23/07/2025
Published 23/09/2025
Publication Time 76 Days
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